Perfusion Imaging
ORGANIZERS: Kamil Uludag, Ph.D. & Matthias J. P. van Osch, Ph.D.
SKILL LEVEL: Basic-Advanced
Saturday, 5 May 2012

This course will provide a framework for setting-up perfusion studies and interpreting results, as well as a glimpse of future techniques that may supplant current state-of-the art methods.
Upon completion of this course participants should be able to:
List the methods used to acquire dynamic susceptibility contrast MRI data and describe the limitations of this technique;
List the methods used to acquire dynamic contrast enhanced MRI data and describe the limitations of this technique;
List the methods used to acquire arterial spin labeling MRI data and describe the limitations of this technique;
Describe the main application areas of perfusion MRI in the brain, heart and other organs;
Describe newly emerging and advanced MRI techniques for non-invasive measurements of blood volume, quantitative oxygenation measurements, as well as vessel-size imaging; and
Explain the physiological interpretation of perfusion measurements.
This course is designed for scientists and clinicians who are working or starting to work in the field of perfusion MRI and would like to have an extensive overview of the scientific and technical underpinnings of these techniques. The course assumes basic previous knowledge of MRI, but not necessarily familiarity with perfusion imaging acquisition and analysis.


Click on to view the abstract pdf. Click on to view the recorded presentation.

  Moderators: Kamil Uludag, Ph.D. & Matthias J. P. Van Osch, Ph.D.
  Perfusion Physiology  
08:30 Anatomy of the Microvasculature, Physiology & Autoregulation David W. Howells, Ph.D.
  Dynamic Susceptibility Contrast MRI (DSC-MRI)  
09:00 Introduction & from Signal to Concentration Linda Knutsson, Ph.D.
09:20 Arterial Input Function & Deconvolution Birgitte F. Kjølby, Ph.D.
09:40 Pitfalls in DSC-MRI : BBB-Breakdown, Dispersion & Delay Fernando Calamante, Ph.D.
10:00 Application: Acute Stroke Søren Christensen, Ph.D.
10:20 Break - Meet the Teachers  
  Dynamic Contrast Enhanced MRI (DCE-MRI)  
10:40 Introduction & Acquisition Methods Josephine H. Naish, Ph.D.
11:00 From the Simplest to the Most Advanced DCE-Model David L. Buckley, Ph.D.
11:20 Applications: From Brain Tumors to Skeletal Studies Geoffrey J. M. Parker, Ph.D.
11:40 Technical Challenges in Cardio Perfusion MRI Michael Jerosch-Herold, Ph.D.
12:00  Subtle BBB-Breakdown Detection in Neurodegenerative Disease Paul A. Armitage, Ph.D.
12:20 Break  
  12:20-12:30 Meet the Teachers  
  Arterial Spin Labeling (ASL)  
13:30 Introduction & Different Approaches to Labeling Eric C. Wong, M.D., Ph.D.
14:00  Quantification: QUIPSS, Single T1 & Multi T1 Laura M. Parkes, Ph.D.
14:20 Improving the ASL Experiment (Background Suppression, Vascular Crushing) Frank Q. Ye, Ph.D.
14:40 Application: ASL in Neuroradiology Joseph A. Maldjian, M.D.
15:00 ASL Outside the Brain David C. Alsop, Ph.D.
15:20 Ultra-High Field ASL: Sequence & Hardware Solutions Susan T. Francis, Ph.D.
15:40 Break - Meet the Teachers  
  Advanced Microvascular Imaging  
16:00 Non-Invasive Blood Volume Measurements Manus J. Donahue, Ph.D.
16:20 Calibrated BOLD & Oxygen Extraction Fraction Measurements Daniel P. Bulte, Ph.D.
16:40 From Macro- to Microvascular ASL: ASL Angiography & Flow Territory Mapping Michael Helle, Dipl.Phys.
17:00 Application: Functional ASL, Pharma Perfusion MRI & Reactivity Measurements Hanzhang Lu, Ph.D.
17:20 Vessel-Size Imaging: Technique & Applications Irene Troprès, Ph.D.
17:50 Adjournment  
  17:50-18:05 Meet the Teachers