ISMRM 21st Annual Meeting & Exhibition ○ 20-26 April 2013 ○ Salt Lake City, Utah, USA |
||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||
OVERVIEW | ||||||||||||||||||||||||||||||||||||||||
Imaging tissue metabolism with hyperpolarized 13C-labeled metabolites has attracted considerable attention since the first publication on dissolution dynamic nuclear polarization (DNP) in 2003. The field has progressed rapidly since then with the first clinical trial of the technique in prostate cancer starting in 2010. This course will deal with the physics of nuclear spin hyperpolarization and the different methods by which this can be achieved, concentrating on dissolution DNP, where the hyperpolarized material is brought rapidly to body temperature for subsequent injection. Methods for fast imaging of hyperpolarized 13C-labeled substrates, which are necessitated by the rapid decay of spin hyperpolarization in vivo, will be discussed along with methods for kinetic analysis of 13C label flux and a survey of how the technique has been used for preclinical studies of metabolism in cardiac and tumor tissue. The course will conclude with a discussion of the results that have been obtained thus far in clinical oncology studies. | ||||||||||||||||||||||||||||||||||||||||
TARGET AUDIENCE | ||||||||||||||||||||||||||||||||||||||||
Basic scientists and radiologists with an interest in metabolism. | ||||||||||||||||||||||||||||||||||||||||
EDUCATIONAL OBJECTIVES Upon completion of this course, participants should be able to: |
||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||
PROGRAM |
||||||||||||||||||||||||||||||||||||||||
Moderator: Arnaud Comment, Ph.D. |
||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||