ISMRM 21st Annual Meeting & Exhibition 20-26 April 2013 Salt Lake City, Utah, USA

Imaging Metabolism with Hyperpolarized Nuclei
SKILL LEVEL: Intermediate to Advanced
ORGANIZERS: Kevin M. Brindle, Ph.D. & Rolf Gruetter, Ph.D.
Monday, 22 April 2013
Imaging tissue metabolism with hyperpolarized 13C-labeled metabolites has attracted considerable attention since the first publication on dissolution dynamic nuclear polarization (DNP) in 2003. The field has progressed rapidly since then with the first clinical trial of the technique in prostate cancer starting in 2010. This course will deal with the physics of nuclear spin hyperpolarization and the different methods by which this can be achieved, concentrating on dissolution DNP, where the hyperpolarized material is brought rapidly to body temperature for subsequent injection. Methods for fast imaging of hyperpolarized 13C-labeled substrates, which are necessitated by the rapid decay of spin hyperpolarization in vivo, will be discussed along with methods for kinetic analysis of 13C label flux and a survey of how the technique has been used for preclinical studies of metabolism in cardiac and tumor tissue. The course will conclude with a discussion of the results that have been obtained thus far in clinical oncology studies.
Basic scientists and radiologists with an interest in metabolism.

Upon completion of this course, participants should be able to:

  • Describe pre-clinical and clinical applications of the technique;
  • Illustrate the principles of nuclear spin hyperpolarization and the different methods for achieving this; and
  • Evaluate fast imaging and kinetic analysis methods that have been used in studies with hyperpolarized 13C-labeled cell metabolites.


Moderator: Arnaud Comment, Ph.D.

14:15 Methods for Hyperpolarizing Nuclei (Optical, Brute Force, PHIP, DNP) Jan H. Ardenkjaer-Larsen, Ph.D.
14:45 Methods for Fast Imaging of Hyperpolarized Nuclei Charles H. Cunningham, Ph.D.
15:15 Preclinical Metabolic Imaging (Cancer, Cardiac, Kinetic Analysis) Daniel M. Spielman, Ph.D.
15:45 Clinical Imaging with Hyperpolarized C-13: The First Steps Sarah J. Nelson, Ph.D.
16:15     Adjournment