ISMRM 21st Annual Meeting & Exhibition 20-26 April 2013 Salt Lake City, Utah, USA

Imaging Muscle Structure & Function
SKILL LEVEL: Intermediate to Advanced
ORGANIZERS: Richard Kijowski, M.D. & William B. Morrison, M.D.
Tuesday, 23 April 2013
Various aspects of imaging muscle, including oxygenation and perfusion, fiber microstructure and organization as well as water and fat composition will be presented by a panel of experts, with lectures ranging from sequence development to clinical applications. It is intended to “bridge the gap” between laboratory research and patient care. Following didactic lectures a “hot topic” representing a relevant abstract will be presented by the author, with subsequent discussion by the panel.
This course is directed to clinicians interested in musculoskeletal MRI as well as researchers seeking to enhance their knowledge of clinical aspects and applications of muscle structure, physiology and composition.

Upon completion of this course, participants should be able to:

  • Apply various MRI techniques to assess muscle structure and function in clinical practice and research studies;
  • Identify advantages and disadvantages of different MRI methods to assess muscle oxygenation and perfusion and muscle fiber structure and orientation; and
  • Develop imaging strategies to evaluate muscle composition using MRI and MR spectroscopy.


Moderators: Robert D. Boutin, M.D. & Michael D. Noseworthy, Ph.D.

13:30 Clinical Aspects of Muscle Physiology & Pathology Robert D. Boutin, M.D.
13:50   Imaging Muscle Oxygenation & Perfusion Michael D. Noseworthy, Ph.D.
14:10 Imaging Muscle Fiber Structure & Function Shantanu Sinha, Ph.D.
14:30 Imaging Muscle Composition Dimitrios Karampinos, Ph.D.
14:50 MR Spectroscopy Laura M. Fayad, M.D.
15:10 Special Abstract Presentation John S. Thornton, Ph.D.
  0314. Candidate Skeletal Muscle Outcome Measures for Therapy Trials: Dependence of MRI Measures Upon Age, Gender and Weight
Jasper M. Morrow1, Christopher D.J. Sinclair1,2, Arne Fischmann3, Mary M. Reilly1, Michael G. Hanna1, Tarek A. Yousry1,2, and John S. Thornton1,2
1MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, England, United Kingdom, 2Academic Neuroradiological Unit, UCL Institute of Neurology, London, England, United Kingdom, 3Department of Radiology, University of Basel, Basel, Switzerland

We performed quantitative MR at 3T in lower limbs of 47 volunteers to investigate the relationship between MR parameters and subject demographics. Transverse maps of fat-fraction (3-point Dixon), T2 time (dual-echo TSE) and magnetisation transfer ratio were analysed at calf and thigh level. Significant positive correlations between age and muscle fat-fraction/T2 time and negative correlation between age and muscle MTR were seen. Weight showed correlation at thigh level only whilst gender didn’t exert a major influence. The magnitude of variation was small compared with expected pathological changes, strengthening the potential utility of MR parameters as outcome measures in neuromuscular diseases.

15:22     Discussion  
15:30     Adjournment