ISMRM 21st Annual Meeting & Exhibition 20-26 April 2013 Salt Lake City, Utah, USA

Single-Subject Neuroimaging
ORGANIZERS: David B. Hackney, M.D. & Karla L. Miller, Ph.D.
Saturday, 20 April 2013
This course will consider the potential of MR neuroimaging to provide robust and reliable information at the level of individuals. Although some MRI methods have been highly effective in this context (e.g., conspicuity of certain types of tumors, vascular abnormalities or lesions), the vast majority of techniques are currently only effective at the group level. This course will consider the challenges at the single subject level (e.g., normal population variability), overview the methodological approaches that have been proposed and clarify the requirements for single-subject neuroimaging across a spectrum of applications in basic and clinical neuroscience.
The ideal audience will have some familiarity with neuroimaging in either the clinical or basic science setting. The course is appropriate for scientists and clinicians from a range of backgrounds, including neuroimaging methodology, data analysis, and basic and clinical neuroscience. The panel discussion will aim to bring together this diverse group to facilitate understanding of this multi-disciplinary problem.

Upon completion of this course, participants should be able to:

  • Assess the primary challenges to single-subject neuroimaging from both a methodological and neuroscientific perspective;
  • Contrast the requirements of single-subject neuroimaging to more conventional group studies;
  • Illustrate these challenges using concrete examples of problems that have been more or less successful in single subjects;
  • Distinguish between problems that are appropriate for multi-variate classification and those that are amenable to more conventional approaches; and
  • Propose candidate criteria for evaluating success in single-subject phenotyping and recognize potential weaknesses in such criteria.


Moderators: David B. Hackney, M.D. & Karla L. Miller, Ph.D.

      Single-Subject Neuroimaging: Methods & Challenges  
08:30 What's Normal? Accounting for Population Variability Guido Gerig, Ph.D.
08:50   Drawing A Line: Multi-Variate Classification -permission withheld Maria J. Rosa, Ph.D.
09:10 From Group Analysis to Individual Studies: Statistical Considerations Jeanette A. Mumford, Ph.D.
      What Can & Can't We Do Currently?  
09:30 Pre-Surgical Planning: Movement, Language & the Power of Localization Susan Y. Bookheimer, Ph.D.
09:50 Spatial Imaging Patterns in AD & Its Prodromal Stages Identified via Pattern Recognition Methods Christos Davatzikos, Ph.D.
10:10 Reliability of MR in Psychiatric Disorders John D. Port, M.D., Ph.D.
10:30     Break & Meet the Teachers  
      Rapid-Fire: What's Your Application?  
11:00   TBI Diagnosis & Prognosis Pratik Mukherjee, M.D., Ph.D.
11:10 Stroke & the Myth of Quantitation Greg Zaharchuk, M.D., Ph.D.
11:20 The Brain Stress Test Richard B. Buxton, Ph.D.
11:30 Real-Time fMRI, Brain States & Biofeedback Xiaoping P. Hu, Ph.D.
11:40   MRI in the Courtroom (pre-recorded) -permission withheld Teneille R. Brown, J.D., B.A.
12:00     Panel Discussion All Faculty
12:30     Adjournment  
      12:30-12:45 Meet the Teachers