ISMRM 21st Annual Meeting & Exhibition 20-26 April 2013 Salt Lake City, Utah, USA

Translational Scientific Session: Musculoskeletal Translational Imaging
Thursday 25 April 2013
Room 255 BC  13:30 - 15:30 Moderators: Christopher J. Hamrahan, Roland Krug

13:30 0682.   Introduction
Timothy Mosher


13:42 0683.   Clinical Assessment of Knee MRI in the Presence of Metal Implants Comparing MAVRIC-SL and FSE at 1.5T and 3T
Hans Liebl1, Ursula Heilmeier1, Sonia Lee1, Lorenzo Nardo1, Christopher Schuppert1, Misung Han1, Suchandrima Banerjee2, Kevin Koch3, Thomas M. Link1, and Roland Krug1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States, 2GE healthcare, Menlo Park, California, United States, 3GE healthcare, Milwaukee, Wisconsin, United States

3D Multi-Spectral Imaging techniques such as MAVRIC and SEMAC are currently being investigated to improve MR-imaging in the presence of metal hardware. We study the performance of MAVRIC-SL at 1.5T vs. 3T compared to standard-of-care sequences. Detection rates for cartilage and bone lesions created in the proximity of metallic hardware placed in twelve pigknee specimens were analyzed and the sizes of artifacts measured. Preliminary data analysis indicates significantly better lesion detection in MAVRIC compared to conventional sequences at both field strengths. Comparing field strenghts, no significant differences were found in lesion detection, but artifact sizes were measured larger at 3T.

13:54 0684.   
Assessment of Porcine Intervertebral Disc Specimen pH Via Chemical Exchange Saturation Transfer (CEST) MRI
Gerd Melkus1, Michelle Grabau1, Dimitrios C. Karampinos1,2, and Sharmila Majumdar1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States, 2Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Bavaria, Germany

Studies have linked low pH and loss of glycoaminoglycan in the intervertebral disc of patients with discogenic back pain. Therefore MRI methods to measure pH in intervertebral discs would be valuable in research and clinical settings. The present study performed on phantoms and porcine discs investigates if gagCEST shows pH dependence and if this effect could be used to detect pH changes in the discs. Further, the DIACEST agent Iopromide is injected into the disc specimens to investigate if CEST MRI can be used to detect intervertebral disc pH using this molecule.

14:06 0685.   Technical Feasibility of Two-Component T2* Mapping on Cartilages in Human Knee with 54-TE Acquisitions
Yongxian Qian1, Jinbai Huang1, Vincent K. Lee1, and Fernando Emilio Boada2
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Radiology, New York University, New York, NY, United States

A major challenge to two-component T2* mapping on cartilages in human knee at pixel level is the instability of mapping for the short-T2* component due to insufficient signal-to-noise ratio (SNR) available in clinical setting. A large number of TE acquisitions was proposed in this work to mitigate the demanding of high SNR and stabilize the mapping of short-T2* relaxation. The technical feasibility of this idea was successfully tested in this study.

14:18 0686.   T2 and T2* Relaxometry in the Meniscus Using a Novel, Rapid Multi-Echo Steady State Sequence
Emily J. McWalter1, Garry E. Gold1, Marcus T. Alley1, and Brian Andrew Hargreaves1
1Radiology, Stanford University, Stanford, California, United States

T2 and T2* relaxation time mapping can be used to detect early degeneration of the meniscus; however, current techniques require lengthy scans (10 to 20 minutes per measure). We present a novel, rapid multi-echo steady state technique to simultaneously estimate T2 and T2* relaxation times in the meniscus in under 5 minutes. The relaxation times estimated using this new technique agreed well with standard measures and were obtained in a fraction of the time.

14:30 0687.   Quantitative 23Na MRI of Human Knee Cartilage Using Dual-Tuned 1H/23Na Transceiver Array RF Coil at 7T
Chan Hong Moon1, Jung-Hwan Kim1, Tiejun Zhao2, and Kyongtae Ty Bae1
1Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2MR R&D Collaborations, Siemens Healthcare, Pittsburgh, Pennsylvania, United States

We developed a new high-sensitivity multi-channel 23Na RF coil for knee MRI at 7T. Our 1H/23Na MRI allowed quantitative measurement of [23Na] in knee cartilage by taking into consideration of the 23Na imaging point spread function and 1H imaging cartilage thickness.

14:42 0688.   Advanced Bi-Exponential Analysis of T2* in the Achilles Tendon of Pre- And Post-Operative Patients Using a Variable Echo Time Sequence at 3T
Vladimir Juras1,2, Sebastian Apprich1, Pavol Szomolanyi1, Oliver Bieri3, Xeni Deligianni3, and Siegfried Trattnig1
1MR Centre of Excellence, Department of Radiology, Medical University of Vienna, Vienna, Austria, 2Department of Imaging Methods, Institute of Measurement Science, Bratislava, Slovakia,3Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland

Mono-exponential curve-fitting for T2* calculation in AT can lead to misinterpretation of the results. The suggested algorithm for bi-exponential T2* fitting enables T2* to be a robust parameter that correlates with the actual clinical condition of the patient's tendon. T2* short may be a predictive marker for the probability of an AT rupture, as well as for a re-rupture after surgery. Bi-exponential fitting, although it is computationally more demanding, is also more precise and also allows distinguishing between bound and free water molecules.

14:54 0689.   Soleus Muscle Water T2 Values in Duchenne Muscular Dystrophy: Associations with Age and Corticosteroid Treatment
William D. Rooney1, Sean C. Forbes2, William Triplett3, D-J Wang4, James Pollaro1, Soren DeVos2, Rebecca J. Willcocks3, Richard Finkel5, Barry Russman6, Barry Byrne7, Lee Sweeney8, Glenn A. Walter3, and Krista Vandenborne2
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Department of Physical Therapy, University of Florida, Gainesville, FL, United States,3Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States, 4Radiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States,5Neurology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 6Neurology, Oregon Health & Science University, Portland, OR, United States, 7Department of Pediatrics, University of Florida, Gainesville, FL, United States, 8Department of Physiology, University of Pennsylvania, Philadelphia, PA, United States

The purpose of the study was to investigate the age dependence of MRS water proton qT2 values in healthy control boys and boys with DMD. Data were acquired from 83 DMD boys and 22 healthy controls on 3T MRI instruments at three institutions. 1H MRS data were acquired to estimate 1H2O T2 using a STEAM single voxel located in the soleus muscle. 1H2O T2 values were significantly increased for DMD boys and decreased with age. Corticosteroid treated DMD boys had a lower 1H2O T2 than untreated DMD boys.

15:06 0690.   
Dynamic Diffusion Tensor Parameters in Muscle Tissue Using Single Voxel Multiple Echo Diffusion Tensor Acquisition Technique on a 3T Clinical Scanner
Steven Baete1, Gene Cho1,2, and Eric E. Sigmund1
1Center for Biomedical Imaging, Dept. of Radiology, NYU Langone Medical Center, New York, NY, United States, 2Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY, United States

Dynamic single voxel acquisition of diffusion tensor parameters is demonstrated in an anisotropic phantom and in in vivo skeletal muscle on a 3T clinical scanner. This method, Single Voxel Multiple Echo Diffusion Tensor Acquisition Technique (SV-MEDITATE) encodes multiple echoes generated by five RF-pulses with each a different diffusion weighting and strength. A single voxel is selected by orthogonal slice selective gradients. The resulting single voxel dynamic acquisition can be used to study the transient changes in diffusion tensor parameters, such as in muscle tissue following exercise, where traditional DTI methods lack temporal resolution.

15:18 0691.   Multi-Parameter Quantitation of Coincident Fat and Water Skeletal Muscle Pathology
Christopher D.J. Sinclair1,2, Jasper M. Morrow1, Robert L. Janiczek3, Michael G. Hanna1, Mary M. Reilly1, Tarek A. Yousry1,2, Rebecca S. Samson4, Nikolaus Weiskopf5, Antoine Lutti5, David L. Thomas2, Xavier Golay6, and John S. Thornton1,2
1MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, London, United Kingdom, 2Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, London, United Kingdom, 3United Kingdom, GlaxoSmithKline, Brentford, Middlesex, United Kingdom, 4Department of Neuroinflammation, UCL Institute of Neurology, London, London, United Kingdom, 5Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, London, United Kingdom, 6Department of Brain Repair and Rehabilitation, University College London, London, London, United Kingdom

Quantitative imaging of skeletal muscle may provide important markers of disease for clinical trials. We used quantitative magnetization transfer (qMT) imaging and the IDEAL-CPMG fat-water separation method to quantify the muscle water-component T2 relaxation times and muscle fat-fraction in the calves of patients with inclusion body myositis. A range of pathologies were observed including isolated T2 elevation, isolated fat-fraction increases or both. QMT parameters, such as the bound pool fraction f, reflected the variations and f was decreased in muscle displaying isolated edema. Further investigation of these relationships may allow the identification of muscles involved early in the disease.