Joint Annual Meeting ISMRM-ESMRMB 2014 10-16 May 2014 Milan, Italy

Body MRI

Wednesday 14 May 2014     13:30 - 14:30

Space 1/Power Poster Theatre & Traditional Poster Hall 
Moderators: Ananth J. Madhuranthakam, Ph.D. & Bachir Taouli, M.D.

Click on this video icon to view the introductory session.

  0552.   Combined unsupervised-supervised classification of multiparametric PET/MRI imaging data of the prostate
Sergios Gatidis1, Petros Martirosian1, Thomas Küstner1, Ilja Bezrukov2, Marcus Scharpf3, Christina Schraml1, Nina F Schwenzer1, and Holger Schimdt1,2
1Department of Radiology, University of Tübingen, Tübingen, BW, Germany, 2Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, BW, Germany, 3Department of Pathology, University of Tübingen, Tübingen, BW, Germany

In this study we implemented and evaluated a combined unsupervised-supervised classification algorithm for the analysis of multiparametrc PET/MRI data that allows for robust classification in cases where prior knowledge about the data is limited. We applied the proposed method to [11C]-Choline-PET/MRI data of the prostate and observed high classification accuracy compared to manual tumor delineation and to histological slices. Numerous applications of this approach are conceivable, especially in areas where histopathological correlation is difficult (e.g. brain imaging) and thus knowledge about ground truth is limited.


  0553.   Diffusion-weighted MRI of advanced ovarian cancer: evaluation of the variability of overall disease burden assessment methods
Jennifer C Wakefield1,2, Stavroula Kyriazi1, Jessica M Winfield1, Veronica A Morgan2, Sharon L Giles2, David J Collins1,2, and Nandita M deSouza1,2
1Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Variability of tumor volumetry and ADC in ovarian cancer metastases was assessed in order to establish their value as response biomarkers. Three tumor burden assessment methods were employed (semi-automated region growing and manual segmentation of DW-MRI data and RECIST measurements on CT) and tumor volume and median ADC determined in 16 patients with primary ovarian cancer by a single radiologist. A second radiologist assessed the tumor burden using an identical semi-automated region growing method. Intra- and inter-observer variabilities were evaluated by calculating the Coefficient of Variation (CV). Volume variability was: intra-observer CV 12.3%, inter-observer CV 17.4%, median ADC variability was lower: intra-observer CV 4.3%, inter-observer CV 4.2%.


Sharon L Giles1, Nandita M DeSouza2, David J Collins2, Veronica A Morgan1, Sharon West3, Faith E Davies3, Gareth J Morgan3, and Christina Messiou4
1Clinical Magnetic Resonance Unit, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 2Clinical Magnetic Resonance Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3Haemato-oncology Department, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 4Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

WB-DWI offers an alternative to SS for detection of myeloma bone disease. This prospective study compared extent of disease shown by WB-DWI and SS by body region (measured by image scores) and correlated the imaging burden of disease (measured by scores and ADC metrics) with the pathological assessment of disease (measured by serum paraprotein and bone marrow histology). WB-DWI scores were significantly higher than SS scores per patient and in every body region except the skull. WB-DWI scores were higher in those with a high disease burden, but there were no significant correlations between imaging and pathological measures of disease.


  0555.   Exploration of change of T2* of metastatic and normal cervical lymph nodes caused by 100% oxygen breathing
Chiara Tudisca1, David Price2, Martin Forster3, Heather Fitzke3, and Shonit Punwani1
1University College London, London, United Kingdom, 2University College London Hospital, United Kingdom, 3University College London, United Kingdom

We explore T2* changes induced by breathing 100% oxygen in metastatic and normal lymph nodes in patients with head and neck squamous cell carcinoma and healthy volunteers.


  0556.   Measuring human glomerular morphology and pathology with MRI
Scott C. Beeman1, Luise Cullen-McEwan2, Min Zhang3, Teresa Wu3, Edwin J. Baldelomar4, John P. Dowling2, Jennifer R. Charlton5, Michael S. Forbes5, Amanda Ng2, Qi-zhu Wu2, James A. Armitage2, Victor G. Puelles2, Gary F. Egan2, John F. Bertram2, and Kevin M. Bennett4
1Washington University in St Louis, St Louis, Missouri, United States, 2Monash University, Victoria, Australia, 3Arizona State University, Arizona, United States, 4University of Hawaii at Manoa, Hawaii, United States, 5University of Virginia, Virginia, United States

Nephron number and size are correlated with risk for chronic cardiovascular and kidney disease and may predict renal allograft viability. Unfortunately, there are no techniques to assess total glomerular number and volume in intact human kidneys. This work demonstrates the use of cationized ferritin as a glomerulus-specific MRI contrast agent to measure glomerular number, volume, and spatial distribution and to detect arterial and glomerular damage in human kidneys.


  0557.   CT-like 3D Isotropic Fat-Suppressed Dynamic Contrast Enhanced MR Enterography
Ivan E. Dimitrov1,2, Ananth J. Madhuranthakam2,3, Qing Yuan3, William A. Grissom4,5, Takeshi Yokoo2,3, and Ivan Pedrosa2,3
1Philips Medical Systems, Cleveland, OH, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 5Radiology, Vanderbilt University, TN, United States

Acquisition of clinical dynamic contrast-enhanced (DCE) MR Enterography is challenged by: (1) need for breath-held high-resolution imaging of the entire abdomen and pelvis; (2) homogenous fat suppression over large FOVs; (3) preferred positioning of patient’s arms along the side of the abdomen to increase compliance. To address these challenges we combine: (a) massive parallel imaging acceleration in two directions; with (b) aggressive reduction of the left-to-right FOV with suppression of out-of-FOV signals by combining sagittal 3D excitation for coronal imaging with custom-designed RF pulses having near-zero stopband excitation. These pulses allow for shorter TEs such that the mathematical conditions for proper DIXON-based water/fat separation are maintained. High-resolution fat-suppressed 3D isotropic, CT-like DCE acquisitions of the abdomen/pelvis were achieved.


  0558.   On Contrast-Enhanced MR Imaging in the Presence of Pathological Plasma-Protein Concentrations
Daniel Nanz1, Stefan Götschi2, Johannes M Froehlich3,4, Natalie Chuck2, Raffaele Curcio5, Val Murray Runge2, Gustav Andreisek2, and Andreas Boss2
1Institute for Diagnostic and Interventional Radiology, University Hospital Zürich, Zürich, Zürich, Switzerland, 2Institute for Diagnostic and Interventional Radiology, University Hospital Zürich, Zürich, Switzerland, 3Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETHZ, Zürich, Switzerland, 4Guerbet AG, Zürich, Switzerland, 5Institute of Clinical Chemistry, University Hospital Zürich, Zürich, Switzerland

In an in-vitro study with dilution series of commercially available gadolinium-based MR imaging contrast agents, human-serum albumin and human-serum immunoglobulin G, and based on a multi-variate protein-specific evaluation of the experimental relaxivity data, it could be shown that pathological deviations from normal blood-serum concentration levels of both proteins strongly alter the signal enhancement induced by gadolinium-based MR contrast agents, which may have implications for a wide range of (quantitative) gadolinium-based contrast-enhanced MR imaging applications.


Improved fast multi-station water-fat imaging at 3T
Melissa Hooijmans1, Oleh Dzyubachyk2, Kay Nehrke3, Peter Koken3, Maarten Versluis1, Hermien Kan1, and Peter Boernert1,3
1Radiology, Leiden University Medical Center, Leiden, Zuid-holland, Netherlands, 2Division of Image Processing, Leiden University Medical Center, Leiden, Zuid-holland, Netherlands, 3Philips Research Laboratories, Hamburg, Germany

Whole body MR screening could be interesting in future clinical practice especially for tumor patients or patients at risk for diabetes and metabolic syndrome. One disadvantage of high field imaging in the clinic is the fact that it is highly affected by in homogeneities of the transmit RF field (B1+) resulting in a reduction in the diagnostic confidence. In whole-body imaging the RF penetration can change station by station and therefore the most ideal situation would be to apply fast B1+ shimming for each individual stack. However, the current B1+ mapping methods are time consuming and are limited by SAR constraints. The recently introduced DREAM technique is very fast and can fill this gap in clinical practice as demonstrated in this whole-body water-fat resolved study. Future applications of this approach to whole body multi-contrast imaging including TSE are conceivable.


  0560.   Measurement of Lagrangian strain and Eulerian flow in the abdomen using Continuously Single Shot Tagged Magnetic Resonance Imaging
André M.J. Sprengers1, Matthan W.A. Caan2, Stijn J. Buitink3, Kevin M. Moerman2, Marije P. van der Paardt2, Aart J. Nederveen2, and Jaap Stoker2
1Orthopaedic Research Lab, Radboud University Medical Centre, Nijmegen, Gelderland, Netherlands, 2Radiology, Academic Medical Centre, Amsterdam, Noord Holland, Netherlands, 3Kernfysisch Versneller Instituut, University of Groningen, Groningen, Netherlands

Continuously tagged imaging (CTI) expands the application range of tagged imaging from cardiac research to non-repeatable motion such as motility. By sampling every tag pattern just once before refreshing, the registered information of tagline displacement in the temporal direction changes from the Lagrangian to the Eulerian perspective. This study shows how, analogous to conventional triggered tagged imaging, complementary measures can be extracted from tagline variation in spatial and temporal direction. The two measures were demonstrated in a simulated CTI acquisition in a numerical Shepp-Logan phantom and applied to bowel motion during free breathing in one healthy volunteer.


Magnetic resonance fingerprinting (MRF) for rapid quantitative abdominal imaging
Yong Chen1, Yun Jiang2, Dan Ma2, Katherine L Wright2, Nicole Seiberlich2, Mark A Griswold1,2, and Vikas Gulani1,2
1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Quantitative MR imaging in the abdomen is challenging due to the need for large organ coverage, field inhomogeneities, and respiratory motion. In this study, a rapid and robust MR fingerprinting (MRF) technique was developed for abdominal imaging using the previously introduced MRF framework in combination with a FISP acquisition and a Bloch-Siegert B1 mapping method. This technique allows accurate and simultaneous quantification of T1, T2 and proton density within one clinically feasible breath-hold.


  0562.   Efficient measurement of liver T1, T2 and PDFF by multi-TR, multi-TE single breath-hold 1H MR spectroscopy.
Gavin Hamilton1, Michael S Middleton1, Lisa Clark1, Tanya A Chavez1, Rohit Loomba2, and Claude B Sirlin1
1Department of Radiology, UC San Diego, San Diego, California, United States, 2Department of Medicine, UC San Diego, San Diego, California, United States

We developed a rapid multi-TR, multi-TE 1H MRS sequence for in vivo hepatic fat quantification and characterization that acquires 32 single-average spectra in a single breath-hold. Spectra were acquired without contrast at 3 Tesla in 252 adult subjects. T1 and T2 of liver fat and water, and liver liver proton density fat fraction (PDFF) were measured. Water and fat T1 values were strongly correlated, whereas water and fat T2 values were uncorrelated. For water, T2 increased with increasing T1, whereas for fat, T2 decreased with T1. For increasing PDFF, water T2 decreased and fat T2 increased.


  0563.   Clinical Effectiveness of Three Noninvasive Methods for Detecting Hepatic Fibrosis
Jun Chen1, Meng Yin1, Jennifer Oudry2, Jayant Talwalkar1, Kevin Glaser1, Thomas Smyrk1, and Richard Ehman1
1Mayo Clinic, Rochester, MN, United States, 2Echosens, Paris, France

Since liver biopsy -the reference method- has some significant limitations for detecting hepatic fibrosis, noninvasive technologies have been developed, such as MR Elastography (MRE), Fibroscan and FIBROSpect II. The purpose of this study was to evaluate the clinical effectiveness of these three methods in a single patient population with a consideration for interobserver variations of liver pathology. ROC analysis shows a diagnostic accuracy (>= F2) of 90.7%, 88.9% and 83.0% for MRE, FIBROSpect II and Fibroscan, respectively. MRE has the highest negative predictive value (90.0%), indicating patients without clinically significant fibrosis could be diagnosed by MRE and avoid liver biopsy.


Assessment of fetal lung maturation from diffusion weighted MRI at 3T
Onur Afacan1, Ali Gholipour1, Robert V. Mulkern1, Carol Barnewolt2, Sigrid Bairdain3, Judy Estroff2, Susan Connolly2, and Simon K. Warfield1
1Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States, 2Advanced Fetal Care Center, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States, 3Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States

The aim of the study is to establish the normal range of fetal lung diffusion values measured at 3T in fetuses with normal lung development. We have found a high correlation between ADC and gestational age in fetuses with normal lung development. This study will help to determine whether the diffusion coefficient can be used to assess fetal lung development, which may lead to an improved understanding of the risk factors for adverse outcome, and ultimately facilitate successful fetal intervention in fetuses most at risk of adverse outcome.


  0565.   Pulmonary MRI in Neonatal Medicine
Jean A Tkach1, Alan H Jobe2, Suhas G Kallapur2, Jeffrey A Whitsett2, Robert J Fleck1, Stephanie L Merhar2, Charles L Dumoulin1, and Jason C Woods1,3
1Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 2Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 3Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Respiratory pathologies are common in premature infants. Pulmonary MRI h has the potential to provide detailed diagnostic information about pulmonary anatomy and function. In this study, its potential utility in neonatal medicine was evaluated. Two identical small footprint 1.5T MR systems designed for imaging neonates and installation within the neonatal intensive care unit were employed to perform pre-clinical and neonatal pulmonary MRI exams. The results demonstrate the feasibility and utility of this neonatal imaging platform to obtain detailed diagnostic thoracic MRI in the neonate, perform longitudinal studies of normal and abnormal lung development, and to evaluate treatment response to therapy.


  0566.   Functional lung MRI for non-invasive monitoring of regional effects of inhaled hypertonic saline in children with cystic fibrosis
Sajoscha A. Sorrentino1, Julius Renne1, Christian Schoenfeld1, Jan Hinrichs1, Marcel Gutberlet1, Andreas Voskrebenzev1, Burkhard Tuemmler2, Frank Wacker1, and Jens Vogel-Claussen1
1Radiology, Hannover Medical School, Hannover, Germany, 2Pediatric Pulmonology, Hannover Medical School, Hannover, Germany

This study shows for the first time a significant increase in pulmonary blood flow and oxygenation after a single treatment with inhalation of hypertonic saline (7% NaCl) in patients with cystic fibrosis, assessed by functional lung MRI, making it a promising, non-invasive, radiation-free tool for visualization and quantification of regional effects in the treatment of patients with cystic fibrosis.