Joint Annual Meeting ISMRM-ESMRMB 2014 10-16 May 2014 Milan, Italy

Clinical & Translational Cartilage MRI

Monday 12 May 2014
Yellow 1, 2 & 3  14:15 - 16:15 Moderators: Neal K. Bangerter, Ph.D., Edwin H. G. Oei, M.D., Ph.D.

14:15 0147.   3D Visualization of Quantitative T2 Relaxation Times in the Femoral Condylar Cartilage in Healthy and ACL-injured Individuals
Uchechukwuka D Monu1,2, Emily J McWalter2, Caroline D Jordan2,3, Brian A Hargreaves1,2, and Garry E Gold2,3
1Electrical Engineering, Stanford University, Stanford, California, United States, 2Radiology, Stanford University, Stanford, California, United States,3Bioengineering, Stanford University, Stanford, California, United States

Osteoarthritis is a degenerative joint disease that may affect more than half of the ACL-injured population. Current MRI osteoarthritis studies often evaluate just a single slice from the medial and lateral compartments of the full knee, which may not fully describe the cartilage volume variation or longitudinal changes. In this work, we provide a method of visualizing quantitative maps of the entire cartilage surface using projection maps. T2 relaxation time differences between healthy volunteers and ACL-injured subjects are clear and the global percent short term CV of the implemented technique is comparable to the ROI approach reported in literature.

14:27 0148.   The angular dependence of T1lower case Greek rho relaxation in normal and abnormal patellae with histological correlation
Jiang Du1, Chantal Pauli2, Shihong Li1, Sheronda Statum1, Won Bae1, Eric Chang1, and Christine B Chung1
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Pathology, University Hospital Zürich, Zürich, Switzerland

Both T2 and T1rho have been employed to evaluate articular cartilage degeneration. The magic angle effect in T2 relaxation is well understood. However, the literature regarding T1rho relaxation mechanisms is inconsistent. Some researchers reported much reduced or negligible magic angle effect in T1rho, while other researchers have reported significant magic angle effect in T1rho relaxation. Furthermore, magic angle effects in normal vs. abnormal cartilage are unknown. In this study we aimed to systematically evaluate the magic angle effect on T2 and T1rho in histological confirmed normal and abnormal cartilage at 3T

14:39 0149.   Sensitivity of Multicomponent Driven Equilibrium Single Observation of T1 and T2 (mcDESPOT) to Magic Angle Effects in Bovine Articular Cartilage at 3.0T
Rajeev Chaudhary1, Fang Liu2, Nade Sritanyaratana1, Jarred M. Kaiser3, Samuel A. Hurley2, Walter F. Block1,2, and Richard X. Kijowski4
1Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Radiology, University of Wisconsin-Madison, Madison, WI, United States

This study was performed to investigate the influence of the magic angle effect on multi-component T2 parameters measured using mcDESPOT. Ex-vivo articular cartilage specimens were imaged using mcDESPOT at angles of 0°, 30°, 55°, and 60° relative to the main magnetic field. Percent changes in T2 parameters from 0° to 55° where there was maximum magic angle effect was 42.9% for single-component T2, 20.0% for T2 of bulk water loosely bound to the macromolecular matrix, 40.0% for the T2 of water tightly bound to proteoglycan, and -4.9% for the fraction of water tightly bound to proteoglycan.

14:51 0150.   Hip T1rho and T2 relaxation times in individuals with and without cartilage lesions
Cory Wyatt1, Deepak Kumar1, Karupppasamy Subburaj2, Divya Narayanan3, Sonia Lee1, Lorenzo Nardo1, Thomas Link1, Thomas Vail4, Richard Souza1, and Sharmila Majumdar1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CALIFORNIA, United States, 2Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States, 3Bioengineering, University of California Berkeley, Berkeley, California, United States, 4Orthopaedic Surgery, University of California San Francisco, San Francisco, CALIFORNIA, United States

The purpose of this study was to measure T1rho and T2 relaxation times in vivo in healthy controls, subjects with mild OA, and subjects with femoroacetabular impingement (FAI). The volunteers were scanned with a segmented 3D SPGR MAPSS T1rho/T2 sequence on one hip and the cartilage was clinically scored for lesions. The femoral and acetabular cartilage were segmented separately and then segmented into 8 equal regions. Significant increases in the T1rho and T2 relaxation times were seen in the acetabular cartilage while no significant changes were seen in the femoral cartilage.

15:03 0151.   Diagnostic performance of a 3D FSE T2 and T1rho sequence for quantitative mapping of articular cartilage composition for the detection of morphological internal knee derangements
Edwin H. Oei1,2, Weitian Chen3, Jason L. Dragoo4, and Garry E. Gold1,5
1Radiology, Stanford University, Stanford, California, United States, 2Radiology, Erasmus MC, Rotterdam, ZH, Netherlands, 3GE Healthcare, Menlo Park, California, United States, 4Orthopaedic Surgery, Stanford University, Stanford, California, United States, 5Bioengineering, Stanford University, Stanford, California, United States

Although quantitative MRI for articular cartilage composition shows promise for early detection of osteoarthritis (OA), large-scale application is hampered by long scan times if added to routine MRI protocols. We assessed the performance of a quantitative 3D FSE T2 and T1rho mapping sequence to diagnose cruciate ligament and meniscal tears, bone marrow lesions, and cartilage defects. For anterior cruciate ligament and medial meniscal tears, diagnostic performance of the 3D FSE T1rho mapping sequence was good and superior to T2 mapping. This sequence may be used to replace routine clinical pulse sequences, enhancing scan time efficiency and potentially accelerating large-scale implementation.

15:15 0152.   
Sodium MRI of Articular Cartilage with Improved SNR Using Coherent SSFP Imaging at 7T
Stefan Zbyn1, Oliver Bieri2, Vladimir Mlynarik1, Vladimir Juras1, and Siegfried Trattnig1
1High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria, 2Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland

Coherent steady state sequences, such as FISP or TrueFISP, may provide higher SNR than spoiled gradient echo (SPGR). However, to our best knowledge, they have not yet been investigated for in vivo 23Na-MRI. In this study, in vivo and ex vivo knee measurements at 7T were performed to assess optimal measurement parameters for FISP and TrueFISP, and to evaluate their SNR compared to SPGR. FISP and TrueFISP provided significantly higher SNR than SPGR in cartilage, muscle and blood. The higher SNR may be traded off for higher resolution or shorter measurement times and help to get 23Na-MRI into clinical practice.

15:27 0153.   UTE MR Morphology and Histopathology of the Osteochondral Junction of the Knee - permission withheld
Won C Bae1, Sheronda Statum1, Reni Biswas1, Darryl D D'Lima2, Eric Y Chang3,4, and Christine B Chung3,4
1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Scripps Clinic, La Jolla, CA, United States, 3VA San Diego Healthcare System, San Diego, CA, United States, 4University of California, San Diego, San Diego, CA, United States

UTE MRI enables direct evaluation of osteochondral junction of the knee. This study compared UTE MR morphology and histopathologic changes of the osteochondral junction, including duplication of tidemark and vascular invasion. While the occurrence of tidemark duplication was similar between UTE-normal and –abnormal samples, vascular invasion was significantly greater in UTE-abnormal samples. Further investigation is warranted to fully understand relationship between osteochondral changes and UTE MR morphology.

15:39 0154.   Longitudinal texture changes to UTE-T2* following ACL reconstruction
Ashley Williams1, Yongxian Qian2, and Constance R Chu1
1Department of Orthopedic Surgery, Stanford University, Stanford, CA, United States, 2Radiology, University of Pittsburgh, Pittsburgh, PA, United States

This study tests the hypothesis that evaluation of the spatial distribution of cartilage UTE-T2* values, assessed via grey-level co-occurrence matrix texture statistics, will better detect sub-surface damage and disease progression to cartilage in ACL-injured subjects than mean UTE-T2* alone. Both cross-sectional comparisons with uninjured controls and longitudinal evaluations of ACL-injured subjects over 2 years after ligament reconstruction indicate that texture analyses provide evidence of progressive cartilage degeneration following ACL-injury that is not reflected in mean UTE-T2* value. Texture evaluations in this work augmented the ability of UTE-T2* mapping to quantitatively monitor cartilage status in knees at risk of developing OA.

15:51 0155.   Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is superior to T1rho-mapping in measuring cartilage sulphated glycosaminoglycan content: preliminary results of an in-vivo validation study using an ex-vivo reference standard for cartilage sulphated glycosaminoglycan content
Jasper van Tiel1,2, Gyula Kotek1, Max Reijman2, Pieter K. Bos2, Esther E. Bron1,3, Stefan Klein1,3, Jan A. Verhaar2, Gabriel P. Krestin1, Harrie Weinans2,4, and Edwin H. Oei1
1Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands, 2Orthopedic Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands, 3Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands, 4Orthopedic Surgery, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has become a standard to quantitatively measure cartilage sulphated glycosaminoglycan (sGAG) content. T1rho-mapping has been proposed as non-contrast-enhanced alternative to dGEMRIC to also quantitatively measure cartilage sGAG content. However, no thorough validation studies comparing both techniques acquired in-vivo against a tissue reference standard for sGAG have been performed. Our preliminary results suggest that dGEMRIC can accurately measure articular cartilage sGAG content, whereas T1rho-mapping is not suitable for this purpose. Therefore, despite the need to use a contrast agent, we consider dGEMRIC to be superior to T1rho-mapping for quantitatively measuring cartilage sGAG content.

16:03 0156.   Combination of a radial sequence for in vivo DTI of articular cartialge with an iterative model-based reconstruction
Jose G Raya1, Florian Knoll1, Lauren Burcaw1, Sina Milani1, Daniel K Sodickson1, and Tobias K Block1
1New York University Langone Medical Center, New York, NY, United States

We combine of a radial spin echo diffusion tensor imaging (RAISED) sequence for DTI of articular cartilage with a model-based iterative reconstruction, which directly calculates the diffusion tensor without reconstructing the intermediate diffusion-weighted images. This adds flexibility to the data acquisition. Purpose of this work was to assess value of different acquisition strategies for a model-based reconstruction. We tested four protocols with different resolutions, b-values and acquisitions times. We compared our model-based approach with the standard gridding reconstruction. We found improvement of the DTI parameters with the model based reconstruction and identify an optimal protocol for RAISED.