Joint Annual Meeting ISMRM-ESMRMB 2014 10-16 May 2014 Milan, Italy

Lung & Mediastinum

Tuesday 13 May 2014
Blue 1 & 2  10:00 - 12:00 Moderators: Mark L. Schiebler, M.D., Jim M. Wild, Ph.D.

10:00 0290.   
Intratracheal administration of Gd-based nanoparticles: an effective approach for MRI detection and follow-up of lung tumor
Andrea Bianchi1, Sandrine Dufort2,3, François Lux4, Nawal Tassali1, Pierre-Yves Fortin1, Olivier Tillement4, Jean-Luc Coll2, and Yannick Crémillieux1
1Centre de Résonance Magnétique des Systèmes Biologiques, Université Bordeaux Segalen, Bordeaux, Bordeaux, France, 2Université Joseph Fourier, Grenoble, France, 3Nano-H, Saint Quentin-Fallavier, France, 4Institut Lumière Matière, Université Claude Bernard, Lyon, France

Lung cancer is the leading cause of cancer deaths worldwide. The burden of this disease could be greatly reduced with an early diagnostics. We present here an in vivo MRI longitudinal study of lung cancer detection in tumor-bearing mice through intratracheally- and intravenously-administered multimodal Ultra-Small Rigid Platforms and a commercial Gd-based contrast agent. The localization of the tumors was validated against bioluminescence imaging and histology. In this study we showed for the first time that the synergic employment of a strongly T1-weighted MRI UTE sequence and high-relaxivity gadolinium-based nanoparticles allow the high-precision detection of lung tumor and of its contours.

10:12 0291.   Histopathology of Lung Adenocarcinoma Based on New IASLC/ATS/ERS Classification: Prognostic Stratification With Functional and Metabolic Imaging Biomarkers - permission withheld
Ho Yun Lee1
1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, Korea

A lung adenocarcinoma is a heterogeneous tumor, and it usually consists of variable combinations of two or more histologic subtypes. In the new IASLC/ATS/ERS international multidisciplinary classification of lung adenocarcinoma, invasive adenocarcinomas are reclassified as lepidic, acinar, papillary, and solid subtypes in consideration of their predominant patterns of constituents; in addition, the micropapillary subtype has been added as a new histologic subtype. Previous studies have already used this subclassification system and validated its important prognostic implications. We hypothesized that histological subtypes of lung adenocarcinoma differ in terms of SUVmax in PET and ADC values in DWI. The purpose of our study was to correlate the results of subtyping and grading of lung adenocarcinoma based on new IASLC/ATS/ERS Classification with SUVs at PET/CT and ADC values at DWI.

10:24 0292.   
MRI as a complementary tool in motion management for patients undergoing radiation therapy for thoracic tumors
Xiutao Shi1, Tejan Diwanji1, Jolinta Lin1, Warren D. D'Souza1, and Nilesh N. Mistry1
1Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, United States

Appropriate selection of the internal margin for mobile tumors is paramount for patients with thoracic tumors in order to adequately direct the radiation dose to the tumor while sparing healthy tissues. In this study, the adequacy of the margins determined with the conventional 4DCT treatment planning images was looked into by comparing the tumor movement – quantified with template matching – in cine-MRI images to that in 4DCT images. Results from the study show that margins determined with 4DCT are often not enough and MRI can be an important complementary tool in determining margins due to the non-ionizing nature.

10:36 0293.   Dynamic Oxygen-Enhanced MRI vs. Quantitative Thin-Section CT: Capability for Pulmonary Functional Loss Assessment and Clinical Stage Classification in Asthmatics - permission withheld
Yoshiharu Ohno1, Shinichiro Seki2, Mizuho Nishio1, Hisanobu Koyama2, Takeshi Yoshikawa1, Sumiaki Matsumoto1, Nobukazu Aoyama3, Makoto Obara4, Marc van Cauteren5, Hideaki Kawamitsu3, and Kazuro Sugimura2
1Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan, 2Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan, 3Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Hyogo, Japan, 4Philips Electronics Japan, Tokyo, Japan, 5Philips Healthcare Asia Pacific, Tokyo, Japan

Dynamic O2-enhanced MRI is suggested as useful for separate assessments of regional ventilation and oxygen transfer in smokers. However, there are no reports about capability of assessment of dynamic O2-enhanced MRI for pulmonary functional loss assessment and clinical stage classification in asthmatics. We hypothesized that dynamic O2-enhanced MRI has potential for functional loss assessment and clinical stage classification in asthmatics as well as quantitatively assessed thin-section CT. The purpose of the study reported here was to prospectively and directly compare the efficacy of dynamic O2-enhanced MRI and quantitative CT for functional loss assessment and clinical stage classification in asthmatics.

10:48 0294.   Oxygen-enhanced T1-mapping MRI of the lung in patients with chronic lung-allograft dysfunction
Jens Vogel-Claussen1, Julius Renne1, Peer Lauermann1, Jan Hinrichs1, Christian Schönfeld1, Sajoscha Sorrentino1, Marcel Gutberlet1, Peter Jakob2, Axel Haverich1, Gregor Warnecke1, Tobias Welte1, Frank K Wacker1, and Jens Gottlieb1
1Hannover Medical School, Hannover, Niedersachsen, Germany, 2University of Würzburg, Würzburg, Germany

Oxygen-enhanced T1 mapping MRI of the lung is capable of detecting pulmonary alterations occurring in patients with chronic lung rejection after transplantation. The coefficient of variation and ÄT1 between room air and 100% oxygen may serve as novel biomarkers for early bronchiolitis obliterans syndrome (BOS).

11:00 0295.   3D pulmonary perfusion MRI with radial ultra-short echo time and spatial-temporal constrained reconstruction
Grzegorz Bauman1, Kevin M Johnson1, Laura C Bell1, Julia V Velikina1, Alexey A Samsonov1, Scott K Nagle1,2, and Sean B Fain1,2
1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

In this work we present a novel DCE MRI technique that combines a time-resolved 3D UTE acquisition with constrained reconstruction for assessment of regional lung perfusion. High isotropic spatial resolution is achieved by acquiring undersampled data for each time frame and reconstructing it using dimensionality reduction in temporal domain via principal component analysis and wavelet soft-thresholding in spatial domain. We present feasibility of this technique in simulations using a fractal-based digital lung phantom and in vivo experiment in a human subject.

11:12 0296.   Ultra-short echo-time MRI distinguishes ischemia/reperfusion injury from acute rejection in a mouse lung transplantation model - permission withheld
Natalie Christine Chuck1, Wolfgang Jungraithmayr2, Moritz Wurnig1, Markus Weiger3, and Andreas Boss1
1Institute for Diagnostic and Interventional Radiology, University Hospital Zürich, Zürich, Zürich, Switzerland, 2Division of Thoracic Surgery, University Hospital Zürich, Zürich, Switzerland, 3Institute for Biomedical Engineering, Swiss Federal Institute for Technology Zürich, Zürich, Zürich, Switzerland

In this study we wanted to show that ultrashort echo-time sequences are capable of identifying and characterizing changes in the lung parenchyma that appear after allogeneic lung transplantation. We used a mouse model and compared the allogeneic transplanted mice to syngeneic transplanted group in order to differentiate the changes from ischemia/reperfusion injury which also often occurs after lung transplantation. Therefore we scanned the animals on three different time points after the transplantation using conventional T2 sequences as well as UTE sequences with different echo times.

11:24 0297.   
Blood volume fraction imaging of the human lung using a ECG-synchronized STEAM-prepared HASTE sequence
Flavio Carinci1,2, Cord Meyer2, Felix A Breuer1, Simon Triphan1,3, and Peter M Jakob1,2
1Research Center Magnetic Resonance Bavaria (M.R.B.), Würzburg, Germany, 2Department of Experimental Physics 5, University of Würzburg, Würzburg, Germany, 3Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany

Knowledge of the regional blood volume fraction in the lungs is of particular interest for the assessment of lung functionality and the diagnosis of several lung diseases, as well as for the T1 and T2 quantification when using multi-compartmental models. In this work a non-contrast enhanced MR-technique for in-vivo imaging of the blood volume fraction in the human lung is presented. To this end a ECG-synchronized STEAM-prepared HASTE sequence was used. The results show a wide distribution of the blood volume fraction within the lung parenchyma with an average value of about 35%.

11:36 0298.   
Towards 3D Dynamic MRI of the Lung using Blind Compressed Sensing
Sajan Goud Lingala1, Yasir Baqqal1, John Newell1, Dingxin Wang2, Jessica C Sieren1, Daniel Thedens1, and Mathews Jacob1
1University of Iowa, Iowa city, Iowa, United States, 2Siemens Medical Solutions, Minneapolis, MN, United States

3-D dynamic MRI of the lung is a promising tool to assess lung function and mechanics. Compared to multi-slice 2D-DMRI, 3-D acquisitions enables the accurate estimation of lung volumes and its variations. However, its full potential is not clinically realized due to restricted spatio-temporal resolutions and volume coverage. In this work, we propose to employ a blind compressed sensing (BCS) scheme to overcome existing trade-offs with 3D-DMRI. The BCS scheme exploits the sparsity of the dynamic dataset in a dictionary of temporal bases that are estimated from the measurements. Since the bases are learnt from the data at hand, they are more representative of the temporal variations within the data, and are expected to provide sparser representations than compressed sensing (CS) schemes that utilize predetermined bases. In addition, it does not require any assumptions on the breathing conditions. Additionally, we propose to combine BCS with parallel imaging and golden angle (GA) radial sampling; the combination offers superior incoherence properties. With the BCS scheme, we show feasibilities of imaging the lung during normal breathing at spatial resolutions and time resolutions of upto (2.37mm2, 0.72 sec) slice coverage (16 slices, 4 mm thickness)

11:48 0299.   
Evaluation of pH and vascular perfusion in a lung fibrosis mouse model using respiration gated acidoCEST MRI
Kyle Mitchell Jones1, Edward Randtke2, Christine Howison3, Matt Kottman4, Patricia Sime4, and Mark Pagel5
1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Physical Chemistry, University of Arizona, AZ, United States, 3University of Arizona, AZ, United States, 4University of Rochester, NY, United States, 5Biomedical Engineering and Chemistry, University of Arizona, Arizona, United States

The pH and vascular perfusion of lung fibrotic tissue were measured using a novel respiration gated acidoCEST MRI method to correlate lung fibrosis and pH. It is thought that a low pH environment will activate TGFβ resulting in the up regulation of fibroblasts leading to scar tissue formation; however, directly measuring lung tissue pH in vivo has not been possible until now. Our results show that respiration gating significantly reduced motion artifacts in the lung allowing for accurate pH and perfusion measurements. Both pH and perfusion were shown to increase as lesion volume decreased thereby supporting the proposed hypothesis.