Joint Annual Meeting ISMRM-ESMRMB 2014 10-16 May 2014 Milan, Italy

Advanced Brain Tumor 2

Tuesday 13 May 2014
Red 1 & 2  13:30 - 15:30 Moderators: Jeffry R. Alger, Ph.D., Andrea Falini, M.D.

13:30 0361.   Brain Tumor Hypercellularity Detected in Diffusion Restricted Voxels Outside Contrast Enhancement in Six Human Brains Examined Ex-vivo
Nikolai J Mickevicius1, Elizabeth Cochran2, Scott D Rand3, Jennifer Connelly4, Mona Al-Gizawiy3, Kathleen M Schmainda5, and Peter S LaViolette3
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Pathology, Medical College of Wisconsin, Wisconsin, United States, 3Radiology, Medical College of Wisconsin, Wisconsin, United States, 4Neurology, Medical College of Wisconsin, Wisconsin, United States, 5Radiology, Biophysics, Medical College of Wisconsin, Wisconsin, United States

Presence of restricted diffusion and FLAIR hyperintensity outside of contrast enhancing tumor is a potential imaging biomarker for invasive brain tumor cells.

13:42 0362.   Toward an MRI Estimate of Tumor Interstitial Pressure: Porosity in the Tumor Rim
James Russell Ewing1, Mahdava Aryal1, Nagaraja Tavarekere2, Kelly Keenan2, Swayamprava Panda1, Hassan Bagher-Ebadian3, and Stephen Brown4
1Neurology, Henry Ford Health System, Detroit, MI, United States, 2Anesthesiology, Henry Ford Health System, Detroit, MI, United States, 3Radiology, Henry Ford Health System, Detroit, MI, United States, 4Radiation Oncology, Henry Ford Health System, Detroi, MI, United States

A method of using DCE-MRI data is presented that will lead to a noninvasive estimate of tumor interstitial fluid pressure.

13:54 0363.   Diffusion tensor and magnetization transfer imaging of tumor margin in a rat C6 Glioma Model
Monika Huhndorf1, Olga Will2, Rolf Mentlein3, Olav Jansen1, and Susann Boretius2
1Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel, Germany, 2Section Biomedical Imaging, Department of Radiology and Neuroradiology, Christian-Albrechts-University, Kiel, Germany, 3Anatomical Institute, Christian-Albrechts-University, Kiel, Germany

Glioblastoma multiforme is the most malignant brain tumor with an infaust prognosis and still a therapeutic challenge, because of its infiltrative tumor growth. Visualizing tumor-cell infiltration non-invasively has been focused by many scientists. Since infiltration starts at the tumor margin, we focused on imaging of this area in a rat C6-glioma model at 7T MRI using diffusion tensor and magnetization transfer imaging. We observed an increase in fractional anisotropy and MT saturation at the tumor margin beyond the tumor region visible on T2-weighted images indicating structural changes in peritumoral tissue.

14:06 0364.   High Cellularity Subvolume in Glioblastoma identified by High b-value Diffusion Weighted Images
Priyanka P Pramanik1, Hemant A Parmar2, Aaron G Mammoser3, Larry R Junck3, Theodore S Lawrence1, Christina I Tsien1, and Yue Cao1
1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, 2Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 3Department of Neurology, University of Michigan, Ann Arbor, MI, United States

The blood-brain(tumor)-barrier could impact therapeutic efficacy of glioblastoma, particularly in the non-enhanced component, which is difficult to differentiate from edema using conventional MRI. This study explores high b-value Diffusion Weighted Imaging (DWI) as a means to identifying the non-enhanced solid tumor. Our study shows that a large non-enhanced high cellular tumor volume extracted from b=3000 s/mm^2 DWI is associated with a higher likelihood of non-central recurrence. High b-value DWI shows promise for aiding in radiation therapy target volume definition.

14:18 0365.   Application of stretched-exponentional model of intravoxel incoherent motion in grading astrocytoma and its correlation with astrocytoma proliferative activity
Jing-Jing Jiang1, Ling-Yun Zhao1, Wei Xiong2, Yi-Hao Yao1, Shun Zhang1, Yan Zhang1, Ri-Feng Jiang1, Zhen-Yu Zhou3, and Wen-Zhen Zhu1
1Tongji hospital, tongji medical college, huazhong university of science and technology, Wuhan, Hubei, China, 2MR modality, GE healthcare, Wuhan, Hubei, China, 3MR Research China, GE healthcare, Beijing, China

To evaluate the performance of DWI using the stretched-exponential model of intravoxel incoherent motion(IVIM) in grading astrocytoma and to determine the correlation of astrocytoma with PCNA.

14:30 0366.   Accuracy of Tissue Heterogeneity Corrected MRI-based Treatment Planning in Brain Radiation Therapy
Dilini S. Pinnaduwage1, Morgan Yee1, Martina Descovich1, Josephine Chen1, Atchar Sudhyadhom1, Ken-Pin Hwang2,3, Andras Osztroluczki4, and Jean Pouliot1
1Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 2Global MR Applications and Workflow, GE Healthcare, Houston, TX, United States, 3Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, 4Advantage Workstation Applications, GE Healthcare, Szeged, Hungary

MRI is a necessity for tumor delineation in radiation therapy planning for most cases because it allows the visualization of soft tissue differences. However, the current radiation therapy process uses CT for dose calculation in treatment planning because CT image intensities, unlike MR image intensities show a clear relationship with tissue electron densities, allowing for dose calculation. Thus, MR-CT co-registration is used to transfer the target contours from MRI to CT. The purpose of our work is to determine the accuracy of MRI-based dose calculations by using an automated method to generate a pseudo CT from an input MRI.

14:42 0367.   Amide Proton Transfer and 3D Pseudo-continuous Arterial Spin Labeling MRI in Grading Cerebral Gliomas
Meiyun Wang1, Yan Bai1, Panli Zuo2, Benjamin Schmitt3, Dapeng Shi1, Jie Tian4, and Jinyuan Zhou5
1Department of Radiology, Henan Provincial Peopls's Hospital, Zhengzhou, Henan, China, 2Siemens Healthcare, Beijing, China, 3Siemens Healthcare, Germany, 4Institute of Automation, Chinese Academy of Sciences, Beijing, China, 5Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

This study investigated the value of amide proton transfer (APT) and 3D pseudo-continuous arterial spin labeling (pCASL) MRI in grading gliomas. The results showed a positive correlation between endogenous mobile proteins and CBF in gliomas and suggested that the parameters derived from APT and 3D pCASL MRI are useful in grading cerebral gliomas.

14:54 0368.   
Sodium (23Na) MR Imaging in Pediatric Astrocytomas
Vincent Kyu Lee1, Rafael Ceschin1, Yongxian Qian2,3, Fernando Boada4, James Mountz5, Regina Jakacki6, Ian Pollack7, and Ashok Panigrahy2
1Radiology, University of Pittsburgh, Pittsburgh, Pa, United States, 2Radiology, University of Pittsburgh, Pa, United States, 3Bioengineering, University of Pittsburgh, Pa, United States, 4Radiology, New York University, NY, United States, 5University of Pittsburgh, Pa, United States, 6Pediatrics, University of Pittsburgh, Pa, United States, 7Pediatric Neurosurgery, University of Pittsburgh, Pa, United States

In this study we report the alterations in sodium intensity observed in a spectrum of pediatric gliomas using 23Na MR imaging to characterize the changes. Pediatric astrocytoma patients (total=26; brainstem gliomas (n=10), low grade (n=6), and high grade (n=10) supratentorial gliomas) at different points of therapy were scanned on clinical 3T MRI scanner. An overall increase in sodium concentration in the brain tumors compared to normal appearing grey and white matter is observed, and the heterogeneous tumor response is demonstrated in supratentorial gliomas. Overall results show the viability of sodium scans as a supplement to clinical scans.

15:06 0369.   1H MRS detection of glutamate predicts survival in pediatric medulloblastoma
Martin Wilson1,2, Simrandip K Gill1,2, Lesley MacPherson2, Martin English2, Theodoros N Arvanitis2,3, and Andrew C Peet1,2
1School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, 2Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom, 3Institute of Digital Healthcare, WMG, University of Warwick, Coventry, United Kingdom

Medulloblastoma is the most common malignant brain tumour occurring in childhood and the diversity of outcomes makes this a particularly challenging disease to treat. In this study, 1H MRS was collected from 35 medulloblastoma patients and metabolite biomarkers were investigated to stratify high-risk patients. Glutamate was found to predict survival, and validated prospectively. 1H HR-MAS was collected from a sub-set of patients and agreement between in-vivo and ex-vivo results was found, adding validation to the assignment of glutamate. The identification of glutamate as a predictive biomarker of survival in medulloblastoma provides a clinically viable measure and multi-center reproduction is warranted.

15:18 0370.   In vivo spectroscopic imaging of citrate in gliomas at 3.0 T
Sandeep K Ganji1,2, Akshay Madan1, Zhongxu An1, Elizabeth A Maher3,4, and Changho Choi1,2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 4Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States