Joint Annual Meeting ISMRM-ESMRMB 2014 10-16 May 2014 Milan, Italy

MS in White Matter

Thursday 15 May 2014
Silver  16:00 - 18:00 Moderators: Marco Bozzali, M.D., Raffaele Lodi, M.D.

16:00 0902.   Preferably large fiber damage in the corpus callosum of progressive MS compared with relapsing MS and controls
Bailey Komishke1, Luanne Metz2, Lenora Brown2, and Yunyan Zhang2
1University of British Columbia, Vancouver, BC, Canada, 2University of Calgary, AB, Canada

We recruited 19 patients with advance SPMS and mild RRMS and 19 controls to determine whether tissue damage differs across different regions of the corpus callosum (CC) and between cohorts. Using whole-brain sagittal DTI, we developed a simple template to partition the CC into 6 segments. We found tissue organization different between CC segments and tissue damage the greatest in the body and splenium, which are comprised of large-caliber axons, of SPMS. There was only minimal tissue injury in RRMS but in similar locations. Our results suggest the vulnerability of large-caliber axons likely causing advanced disability in SPMS.

16:12 0903.   Smoking Influences White Matter Alterations In Clinically Isolated Syndrome As Revealed By DTI
Arzu Ceylan HAS1, Gamze DURHAN2, Sevda DIKER3, Asli TUNCER3, and Kader KARLI OGUZ3
1National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey, 2Department of Radiology, Hacettepe University, Ankara, Turkey,3Department of Neurology, Hacettepe University, Ankara, Turkey

Diffusion tensor imaging, multiple sclerosis, clinically isolated syndrome, smoke, white matter, FA, MD.

16:24 0904.   Diffusion abnormalities in the spinal cord grey matter relates to disability in relapse-onset multiple sclerosis
Hugh Kearney1, Torben Schneider1, Marios C. Yiannakas1, Claudia A.M. Wheeler-Kingshott1, Olga Ciccarelli1,2, and David H. Miller1,2
1NMR Research Unit, UCL Institute of Neurology, London, United Kingdom, 2NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom

We have quantified spinal cord abnormalities in people with relapse-onset multiple sclerosis (MS) using diffusion tensor imaging (DTI) in specific white matter and grey matter tracts. Abnormal DTI metrics were evident in the spinal cord of people with clinically isolated syndrome prior to the accumulation of significant levels of physical disability. In both relapsing remitting and secondary progressive MS, DTI values also differed significantly from controls. In the MS cohort (i.e. excluding CIS) there were a number of significant correlations with physical disability in both white matter tracts and the central spinal cord grey matter.

16:36 0905.   
Myelin Water-weighted Imaging
Daeun Kim1,2 and Jongho Lee2
1Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

A new myelin water-weighted imaging (MWwI) method was developed to generate a balanced mixture of myelin water and axonal/extracellular signals in the white matter of the brain. MWwI allows us to acquire myelin water weighted images at the early echoes (< 10 ms), and axonal/extracellular water signals at late echoes.

16:48 0906.   Clinical investigation of whole brain myelin water fraction imaging in patients with multiple sclerosis
Elizabeth Monohan1, Sneha Pandya2, Kyoko Fujimoto1, Thanh D. Nguyen2, Christopher Blackwell1, Nancy Nealon1, Jai S. Perumal1, Ashish Raj2, Tim Vartanian1, and Susan A. Gauthier1
1Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, United States, 2Radiology, Weill Cornell Medical College, New York, NY, United States

The aim of this study was to apply a fast whole T2prep 3D spiral acquisition and a novel post-processing algorithm to a cohort of 141 MS patients and assess its capability in demonstrating the variability in myelin content among lesions and normal appearing white matter.

17:00 0907.   Ultrashort Echo Time (UTE) Contrast in Multiple Sclerosis
Peder Eric Zufall Larson1, Angela Jakary1, Daniel B. Vigneron1, Douglas A. C. Kelley2, Sarah J. Nelson1, and Roland G. Henry1,3
1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, 2Neuro Apps and Workflow, GE Healthcare, Corte Madera, CA, United States, 3Neurology, University of California - San Francisco, San Francisco, CA, United States


17:12 0908.   Ultrashort Echo Time (UTE) Imaging in Multiple Sclerosis
Vipul R Sheth1, Qun He1, Shihong Li1, Shahram Saberi2, Scott Vandenberg2, Graeme M Bydder1, and Jiang Du1
1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2Department of Pathology, University of California San Diego, San Diego, CA, United States

We report on using an inversion recovery prepared ultrashort TE sequence to directly image the ultrashort T2 components of white matter in MS. The IR-UTE sequence shows high contrast between normal and abnormal white matter. It also shows gray matter lesions and high signal from deep gray matter nuclei. This may be a result of iron deposition.

17:24 0909.   Marker of disease progression in patients with relapsing remitting multiple sclerosis using 2D MRSI
Adriane Gröger1, Vinzenz Fleischer1, Rupert Kolb2, Uwe Klose2, and Frauke Zipp1
1Department of Neurology and Neuroimaging Center (NIC), Mainz, Germany, 2Department of Diagnostic and Interventional Neuroradiology, Magnetic Resonance Research Group, Tübingen, Germany

Our findings of increased creatine and myo-inositol levels but not different NAA levels suggest that inflammation processes are more strongly associated with early disease than neuronal loss that is correlated with disease duration. Furthermore, the higher glutamate and glutathione levels in RRMS patients receiving escalation therapy (no alter metabolites pre to post treatment with natalizumab) can be interpreted as a marker for more fulminant disease progression but not for disease duration.

17:36 0910.   Perivascular spaces in MS patients at 7 Tesla MRI: a marker of neurodegeneration?
Iris D Kilsdonk1, Martijn D Steenwijk1, Petra Pouwels2, Jaco JM Zwanenburg3, Jeroen JG Geurts4, Frederik Barkhof1, and Mike P Wattjes1
1Radiology and Nuclear Medicine, VU University medical center, Amsterdam, Noord Holland, Netherlands, 2Physics and Medical Technology, VU University medical center, Amsterdam, Noord Holland, Netherlands, 3Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands,4Anatomy and Neurosciences, VU University medical center, Amsterdam, Noord Holland, Netherlands

Enlarged perivascular spaces - Virchow Robin Spaces (VRS) - in 34 multiple sclerosis (MS) patients and 11 healthy controls were analyzed with high resolution structural MRI at 7T. VRS were measured and related to inflammatory (MS lesion load) and neurodegenerative (brain atrophy) variables. Compared to controls, MS patients showed an increased number of VRS, which was associated with supratentorial brain atrophy, age and disease duration, but not with lesion load. This suggests that VRS might rather serve as a neurodegenerative than an inflammatory radiological marker in MS.

17:48 0911.   Global and regional brain concentration of intra- and extra- cellular sodium in MS: a 7 Tesla MRI study
Matilde Inglese1, Maria Petracca1, Roxana Teodorescu2, Laura Jonkman2, Niels Oesingmann3, and Lazar Fleysher4
1Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States, 2Icahn School of Medicine at Mount Sinai, New York, New York, United States, 3Siemens Healthcare, New York, New York, United States, 4Radiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States

Accumulation of intra-axonal sodium ions represents a key factor in the degenerative process in multiple sclerosis (MS). MRI measurement of total sodium concentration (TSC) is feasible in MS patients. We report the in-vivo measurement at 7 Tesla MRI of intra and extracellular sodium concentrations in MS patients. We describe the potential contribution of sodium dishomeostasis to disease pathophysiology and its clinical impact.