ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • New Insights & Innovations in Cardiovascular MRI

Monday 1 June 2015

Constitution Hall 105 

10:45 - 12:45


Sonia Nielles-Vallespin, Ph.D., T.B.A.

10:45 0019.   Novel Biomarkers of Mitochondrial Function: the Mitochondrial Index and the Crossing Point of Glucose and Oxygen Consumption Curves obtained by Dynamic Deuterium Magnetic Resonance
Gheorghe D Mateescu1, Chris A Flask2,3, Allen Ye4, Bernadette Erokwu5, Michael Twieg6, Karishma Gupta5, and Mark Griswold3,5
1Chemistry, Case Western Reserve University, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Case Western Reserve University, OH, United States, 4Bioengineering, University of Indiana at Chicago, IN, United States, 5Radiology, Case Western Reserve University, OH, United States, 6Biomedical Engineering, Case Western Reserve University, OH, United States

Preliminary results on mice demonstrate that it is possible to simultaneously measure, in vivo, the glucose and oxygen consumption in mitochondria by Dynamic Deuterium MR, following administration of deuteriated glucose. Novel biomarkers for the bio-energetic output of cells in organs and tissues – the Mitochondrial Index and the Crossing Point of the consumption curves – are proposed; their association with the state of health of a live organism and the transferability of the method to the clinic is discussed.

10:57 0020.   Chronic Diabetes Reprograms Carbohydrate Metabolism in the Heart and Kidney: A Hyperpolarised 13C Magnetic Resonance Spectroscopy Study
Marie A Schroeder1,2, Albert P Chen2,3, Albert Tsui4, M Mitchell4, Jean-Francois Desjardins4, Golam Kabir4, Charles H Cunningham2, and Kim A Connelly2,4
1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore, Singapore, 2Schulich Heart Research Program, Sunnybrook Health Science Centre, Toronto, ON, Canada, 3GE-Healthcare, Toronto, ON, Canada, 4Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada

We tested the hypothesis that chronic diabetes would cause clinical signs and symptoms of heart failure with preserved ejection fraction (HFpEF). By following hyperpolarised [1-13C]pyruvate metabolism in heart and kidneys using MRS, we defined how chronic diabetes reprogrammed carbohydrate utilisation. Diabetic rats showed evidence of HFpEF via echocardiography, pressure volume loops and histology, including preserved ejection fraction, diastolic dysfunction, fibrosis, pulmonary congestion, and nephropathy. Hyperpolarised 13C MRS revealed a shift towards lactate production in the heart and kidneys of diabetic rats, which may indicate increased gluconeogenesis and inflammation. Further study of chronic diabetic cardiomyopathy will be important in developing the first treatments for HFpEF.

11:09 0021.   Cardiac metabolic adaptations in diabetic mice protect the heart from pressure overload-induced failure: a combined in vivo MRI, MRS, and PET approach
Desiree Abdurrachim1, Miranda Nabben1, Verena Hoerr2,3, Michael T. Kuhlmann4, Philipp R. Bovenkamp2, Michael Schäfers4, Klaas Nicolay1, Cornelius Faber2, Sven Hermann4, and Jeanine J. Prompers1
1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Department of Clinical Radiology, University Hospital Münster, Münster, Germany, 3Institute of Medical Microbiology, Jena University Hospital, Jena, Germany, 4European Institute for Molecular Imaging, Münster, Germany

Metabolic adaptations in the diabetic heart are proposed as an important contributor to the development of heart failure in diabetes patients. Using in vivo MRI,1H-MRS, 31P-MRS, and PET, we investigated cardiac metabolic, energetic, and functional adaptations in non-diabetic and diabetic mice at baseline, and 1, 5, and 12 weeks after transverse aortic constriction (TAC)-induced pressure overload. While TAC resulted in progressive cardiac hypertrophy and dysfunction in non-diabetic mice, the effect of TAC on cardiac function in diabetic mice was much less prominent, which was associated with a blunted increase in cardiac glucose uptake and maintained cardiac energetics.

11:21 0022.   Alterations in Myofiber Architecture in Response to Left Ventricular Pressure Overload are Associated with the Upregulation of Genes Encoding for Cell Adhesion and Matrix Remodeling
Choukri Mekkaoui1, Howard H Chen1, Yin-Ching Iris Chen1, Marcel P Jackowski2, William J Kostis1, Timothy G Reese1, Ronglih Liao3, and David E Sosnovik1
1Harvard Medical School-Massachusetts General Hospital, Boston, MA, United States, 2University of São Paulo, São Paulo, Brazil, 3Brigham and Women's Hospital, Boston, MA, United States

Left ventricular hypertrophy (LVH) in response to pressure overload is initially adaptive but subsequently becomes maladaptive. We used diffusion tensor MRI (DTI) to determine how myofiber orientation changes in response to LVH in aortic-banded mice. In addition, we performed gene expression analysis to determine which gene pathways were associated with these changes. We show that LVH due to pressure overload is accompanied by a marked rightward shift in fiber orientation in the left ventricular free wall and the upregulation of genes encoding for cell-cell and cell-matrix adhesion.

11:33 0023.   
Flexible Time-Resolved Golden Angle Dual-Inversion Recovery Acquisition to Facilitate Sequence Timing in High-Resolution Coronary Vessel Wall MRI at 3T
Giulia Ginami1,2, Jérôme Yerly1,2, and Matthias Stuber1,2
1Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne and Geneva, Switzerland

Coronary vessel wall MRI based on dual inversion recovery (DIR) is complicated by the need to collect data during both the period of minimal cardiac motion and the optimal blood nulling time. We propose a continuous acquisition scheme throughout an extended acquisition window after DIR. Combined with golden angle radial acquisition and k-t sparse SENSE, our framework enables a fully flexible a posteriori selection of the optimal imaging time and significantly improves vessel wall conspicuity with respect to the conventional acquisition. Our framework alleviates the need of subject-specific sequence timing and improves the success rate of coronary vessel wall imaging.

11:45 0024.   In vivo measurement of vessel wall diffusion anisotropy in carotid arteries
Peter Opriessnig1, Harald Mangge1, Rudolf Stollberger2, David Porter3, Hannes Deutschmann4, and Gernot Reishofer5
1Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria, 2Institute of Medical Engineering, Graz University of Technology, Austria, 3MR R&D, Siemens AG, Healthcare Sector, Erlangen, Germany, 4Department of Radiology, Division of Vascular and Interventional Radiology, Medical University of Graz, Austria, 5Department of Radiology, Division of Neuroradiology, Medical University of Graz, Austria

Multi-contrast MRI has become a well-recognized tool to study the complexity of an atherosclerotic plaque in order to predict lesion vulnerability. Diffusion tensor imaging (DTI) could be an additional measure that provides information on the influence of plaque components on the diffusion process, which may help to understand the formation of a complex disease. In this work, we demonstrate the feasibility to investigate the orientation of diffusion anisotropy in healthy human carotids in vivo. Tangential and radial diffusion were measured by the combination of a read-out segmented EPI (rs-EPI) with a 2D special gradient direction scheme.

11:57 0025.   Steady-state Real-time Cine Imaging of Stress/Rest Myocardial Perfusion for Rapid Detection of High-grade Coronary Stenosis
Behzad Sharif1, Reza Arsanjani1, Hsin-Jung Yang1, Rohan Dharmakumar1, Noel Bairey Merz1, Daniel S. Berman1, and Debiao Li1
1Biomedical Imaging Research Institute, Dept. of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States

We present a multi-slice cine first-pass perfusion imaging method capable of simultaneous detection of stress-induced myocardial perfusion defects and wall motion abnormalities in a single ungated scan using a 1-minute continuous acquisition. Our initial results in ischemic canines demonstrate that worsening of wall motion (compared to rest) in the perfusion defect territories seen in the real-time stress cine perfusion scan may be a marker of severe (high grade) coronary artery disease.

12:09 0026.   
MR Fingerprinting for Quantification of Myocardial T1, T2, and M0
Jesse I. Hamilton1, Yun Jiang1, Yong Chen2, Dan Ma1, Wei-Ching Lo1, Mark Griswold1,2, and Nicole Seiberlich1,2
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States

A major challenge in applying MRF to myocardial tissue characterization is that respiratory and cardiac motion can introduce blurring in parameter maps or lead to failed pattern recognition. A 2D MRF acquisition is presented that employs a single breath hold and ECG triggering to simultaneously map T1, T2, and M0 within 24 heartbeats. Because the exact timing for the experiment differs for each scan due to slight differences in cardiac rhythm, scan-specific dictionaries are used for pattern matching. Six healthy volunteers were scanned at 3T, and myocardial relaxation parameters were in good agreement with literature values.

12:21 0027.   
Five-Dimensional Cardiac and Respiratory Motion-Resolved Whole-Heart MRI
Li Feng1, Simone Coppo2, Davide Piccini2,3, Ruth P Lim4, Matthias Stuber2, Daniel K Sodickson1, and Ricardo Otazo1
1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States,2Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL) / Center for Biomedical Imaging (CIBM), Lausanne, Switzerland,3Advanced Clinical Imaging Technology, Siemens Healthcare IM BM PI, Lausanne, Switzerland, 4Department of Radiology, Austin Health and The University of Melbourne, Melbourne, Victoria, Australia

A framework for five-dimensional (5D) whole-heart MRI is described in this work. Continuously acquired 3D golden-angle radial k-space data are retrospectively sorted into a 5D (x-y-z-cardiac-respiration) image set containing one cardiac motion dimension and one respiratory motion dimension using cardiac and respiratory motion signals. The undersampled 5D images are reconstructed using compressed sensing that exploits sparsity along both cardiac and respiratory dimensions. The method enables both high isotropic spatial resolution and high temporal resolution, allowing simultaneous assessment of myocardial function and visualization of cardiac and respiratory motion-resolved coronary arteries.

12:33 0028.   
Improved free-running self-navigated 4D whole-heart MRI through combination of compressed sensing and parallel imaging.
Simone Coppo1, Li Feng2, Davide Piccini1,3, Jérôme Chaptinel1, Gabriele Bonanno1, Gabriella Vincenti4, Juerg Schwitter4, Ricardo Otazo2, Daniel K. Sodickson2, and Matthias Stuber1
1Department of Radiology, University Hospital (CHUV), University of Lausanne (UNIL), Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York, United States,3Advanced Clinical Imaging Technology, Siemens Healthcare IM BM PI, Lausanne, Switzerland, 4Department of Cardiology, University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland

A novel reconstruction framework that combines dynamic compressed sensing and parallel imaging is integrated with a free-running self-navigated 4D radial whole-heart imaging technique for simultaneous coronary artery visualization and cardiac function assessment. The proposed framework enables a significant increase of the temporal resolution, as well as a significant reduction of streaking artifacts, thus increasing overall image quality compared to the standard gridding reconstruction. Initial results obtained in vivo and in humans are presented.