ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Cartilage Imaging: Technical Developments

Monday 1 June 2015

Room 701 A

14:15 - 16:15


Xiaojuan Li, Ph.D., Miika T. Nieminen, Ph.D.

14:15 0111.   
Response of Quantitative MRI to Artificial Collagen Cross-linking of Articular Cartilage
Jari Rautiainen1,2, Mikko J. Nissi1,2, Elli-Noora Salo3, Harri Kokkonen2,4, Shalom Michaeli5, Silvi Mangia5, Olli Gröhn6, Juha Töyräs2,4, and Miika T. Nieminen1,3
1Medical Research Center Oulu and Department of Diagnostic Radiology, University of Oulu, Oulu, Finland, 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Center for Magnetic Resonance Research, University of Minnesota, MN, United States, 6Department of Neurobiology, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Aging of cartilage results in accumulation of advanced glycation end products (AGEs), most notably collagen cross-links in cartilage. Increased cross-linking of the collagens makes cartilage more stiff and brittle. In this study, sensitivity of quantitative MRI parameters to artificial collagen cross-linking induced by L-threose in bovine articular cartilage was evaluated. Artificial cross-linking detectably changed the biophysical properties of cartilage which were also detected with MRI parameters. While T2 and dGEMRIC responded to the treatment as expected, T1ρ relaxation time constants showed unexpected increase, possibly attributed to an increased cross-linked fraction characterized by the slow motion or blocking of exchange-mediated relaxation.

14:27 0112.   Validation of diffusion tensor imaging of articular cartialge in an animal model of posttraumatic osteoarthritis
Jose G Raya1, Ignacio Rossi1, Oran Kennedy1, Natalie Danna1, Bryan Beutel1, You Jin Lee1, and Thorsten Kirsch1
1NYU Langone Medical Center, New York, NY, United States

We validate DTI of articular cartilage in an animal model of posttraumatic osteoarthritis (PTOA). Eight New Zeeland white rabbits underwent anterior cruciate ligament transection (ACLT) on one of the hindlimbs and sham surgery in the contralateral limb. Rabbits were scarified at 4 (n=4) and 8 weeks (n=4) after surgery. Both joints underwent MRI (PD-weighted and DTI), micro-CT and histology with safranin O. We observe a trend of increased MD in the ACLT joints compared to the sham that was significant at 8 weeks. Changes in MD correlated with areas of PG loss in histology, that only show changes on PG

14:39 0113.   
Rapid T1 and T2 mapping of the hip articular cartilage with radial MR fingerprinting
Martijn A Cloos1, Leeor Alon1, Christian Geppert2, Daniel K Sodickson1, and Riccardo Lattanzi1
1Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 2Siemens AG Healthcare, Erlangen, Germany

Biochemical assessment is critical for early detection and staging of hip articular cartilage damage, as well as to predict risk for progression. We employed the principles of magnetic resonance fingerprinting to explore the feasibility of simultaneous T1 and T2 mapping in clinically feasible scan times. In addition to a PD image, our method quantified T1 and T2 with a 0.8x0.8 mm2 in-plane resolution (scan time of 1:20 min per slice). By enabling a fast comprehensive morphological and biochemical assessment, we hope to improve assessment and staging of cartilage damage, predict risk for progression and impact patient management decisions.

14:51 0114.   Correlation between Cartilaginous endplate defects and Intervertebral disc degeneration: An In Vivo MRI Study at 3.0 Tesla
Dong Xing1, Jiao Wang1, Yunfei Zha1, Lei Hu1, Hui Lin2, and Yuan Lin1
1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China, 2GE Healthcare China, Shanghai, China

Although IVDD is a multifactorial disease, it is well accepted that limited nutrition is the final common pathway for IVDD and the changes in the structure or composition of the cartilaginous endplate (CEP) have been considered a crucial role in IVDD. The ultrashort echo time (UTE) sequence has been used in detecting the CEP defects and the visual classification of IVDD , however, a further study utilized the quantitative parameter of T2*-relaxation time would be benefit to understand the causes of disc degeneration of early stage. The purpose of this study was to use 3D-UTE and T2*- mapping sequence to ascertain the relation between CEP Integrity and IVDD.

15:03 0115.   Metal Artifact Reduction Using a 3D UTE-MSI sequence with Time-Frame Regularized Compressed Sensing Reconstruction
Yifei Lou1, Qun He2, Xun Jia3, Eric Chang2, Christine B Chung2, and Jiang Du2
1Department of Mathematical Sciences, University of Texas Dallas, Dallas, TX, United States, 2Radiology, University of California, San Diego, CA, United States, 3Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Metallic implants are routinely used to treat advanced joint disease. There is a need for non-invasive diagnosis of wear-induced disease. MRI has obvious advantages. However, conventional MR sequences are subject to severe distortion due to strong susceptibility effects near metal, with little or no signal from important joint tissues such as tendons and cortical bone which have very short T2s. 3D ultrashort echo time (UTE) imaging sequences together with multiple spectral imaging (MSI) can potentially image short T2 tissues and minimize metal artifact. However, 3D UTE-MSI is time-consuming. In this study we aimed to develop 3D UTE-MSI using with vastly undersampling to reduce scan time and a tight-frame regularized compressive sensing (TFCS) technique to reduce streak artifacts. T1, magnetization transfer ratio (MTR) and water content of tissues near metal can potentially being measured using a clinical whole-body scanner

15:15 0116.   Effects of bath solutions on the quantitative determination of relaxation times in compressed articular cartilage by microscopic MRI
Nian Wang1 and Yang Xia1
1Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI, United States

A new type of laminar appearance was found in the deep region of compressed articular cartilage at the magic angle by high-resolution MRI, but the origin of this appearance was unclear. Recently, the molecular origin of this loading-induced laminar layer in the deep cartilage was attributed to the GAG loss in cartilage. To investigate the characteristics of this additional low-intensity layer, quantitative MRI T1, T2, and T1ρ experiments were carried out under different orientations when the tissue was soaked in different soaking solution.

15:27 0117.   Determination of correlation time in articular cartilage by T1rho relaxation dispersion
Matti Hanni1,2, Mikko J. Nissi3,4, Jari Rautiainen3,4, Simo Saarakkala2,5, Jutta Ellermann6, and Miika T. Nieminen2,7
1Department of Radiology, University of Oulu, Oulu, Finland, 2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 3Department of Radiology, and Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland, 4Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 5Department of Diagnostic Radiology, Oulu University Hospital, Department of Medical Technology, University of Oulu, Oulu, Finland, 6Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, United States, 7Department of Diagnostic Radiology, University of Oulu and Oulu University Hospital, Oulu, Finland

Reorientational correlation time is a fundamental biophysical property that describes the dynamics of nuclei in any type of tissue. In this abstract, correlation time is investigated as a potential new MRI contrast. It is obtained from MRI T1rho relaxation dispersion measurements of bovine and human articular cartilage in vitro. The fitted correlation times appear to be macromolecule-specific, as well as indicative of early structural changes associated with osteoarthritis.

15:39 0118.   
Magnetic Resonance Imaging as Biomarker of Adverse Local Tissue Reactions in Total Hip Arthroplasty
Matthew F. Koff1, Parina H. Shah1, Alissa Burge1, Mauro Miranda1, Christina Esposito2, Elexis Baral2, Thomas W. Bauer3, Allina Nocon4, Kara Fields4, Stephen Lyman4, HSS Adult Reconstruction & Joint Replacement Division5, Douglas Padgett5, Timothy Wright2, and Hollis G. Potter1
1Department of Radiology and Imaging - MRI, Hospital for Special Surgery, New York, New York, United States, 2Department of Biomechanics, Hospital for Special Surgery, New York, New York, United States, 3Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, United States,4Healthcare Research Institute, Hospital for Special Surgery, New York, New York, United States, 5Adult Reconstruction & Joint Replacement Division, Hospital for Special Surgery, New York, New York, United States


15:51 0119.   Quantitative Susceptibility Mapping (QSM) to correlate with histology and quantitative parametric mapping in surgically induced juvenile osteochondritis dissecans
Luning Wang1, Mikko J Nissi1,2, Ferenc Toth3, Michael Garwood1, Cathy Carlson3, and Jutta Ellermann1
1Center for Magnetic Resonance Research, University of Minnesota, Twin Cities, Minneapolis, MN, United States, 2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland, 3University of Minnesota, Twin Cities, Minneapolis, MN, United States

Juvenile Osteochondritis Dissecans (OCD) is a disease of epiphyseal cartilage occurring subsequent to failure of cartilage canal blood vessels. Minimum intensity projections of MR susceptibility maps together with MR relaxometry can provide a noninvasive approach for a direct correlation between the quantitative assessment of cartilage matrix and the visualization of the canal degeneration at different time points.

16:03 0120.   Cartilage MR T1ρ and T2 quantifications: longitudinal reproducibility and variations using different coils and scanners at single and multi-sites
Xiaojuan Li1, Valentina Pedoia1, Deepak Kumar1, Drew Lansdown1, Cory Wyatt1, Julien Rivorie1, Narihiro Okazaki1, Dragana Savic1, Matthew F Koff2, Joel Felmlee3, Williams Steven3, and Sharmila Majumdar1
1University of California, San Francisco, CA, United States, 2Hospital for Special Surgery, New York, NY, United States, 3Mayo Clinic, Rochester, MN, United States

MR T1ρ and T2 mapping are promising techniques that have potential as early markers of cartilage degeneration. Currently, applications of cartilage T1ρ and T2 imaging in multicenter clinical trials are very limited. One impeding factor is the lack of documentation of potential variations of T1ρ and T2 introduced by different scanners, coils and sites. In this report, we evaluate the longitudinal reproducibility of T1ρ and T2, and the variation of T1ρ and T2 by using different scanners and coils at one site, and the reproducibility and cross-validation of T1ρ and T2 among three sites.