ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Power Pitch Session
Power Pitch Theatre, Exhibition Hall, 13:30 - 14:30
Plasma Screens, Exhibition Hall, 14:30 - 15:30
Moderators: Elizabeth M. Hecht, M.D., Valentina Taviani, Ph.D.
Thursday 4 June 2015

Click this video icon to view the introductory session:

Note: The videos below are only the slides from each presentation. They do not have audio.

Plasma # Program #  
1 0838. Does using a 16-element receive-array improve whole-liver 31P metabolite ratio quantification at 7T?
Lucian A. B. Purvis1, William T. Clarke1, Michael Pavlides1, Stefan Neubauer1, Matthew D. Robson1, and Christopher T. Rodgers1
1Department of Cardiovascular Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom

Using a 16-element receive array at 7T permitted precise quantification of 31P metabolite ratios from the whole liver, in a study on 5 normal volunteers. A 3D UTE-CSI sequence gave an average of 27 voxels (each 6.3mL nominal volume) of high quality data for each subject. The inter-subject mean and SD of the metabolite ratios (averaged over all voxels) were then calculated: 36.4 ± 6.94 for PME/PDE, 44.4 ± 3.93 for GPC/Total Ester and 12.6 ± 3.58 for PE/Total Ester. This preliminary work will inform the design of future clinical studies of diseases such as non-alcoholic fatty liver disease.

2 0839. Combined Gadoxetic Acid and Gadofosveset enhanced Liver MRI: Detection and Characterization of Focal Liver Lesions
Peter Bannas1,2, Candice A Bookwalter1, Tim Ziemlewicz1, Utaroh Motosugi1, Richard Bruce1, Theodora A Potretzke1, and Scott B Reeder1,3
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 3Medical Physics, University of Wisconsin-Madison, WI, United States

On gadoxetic acid enhanced hepatobiliary-phase MRI it can be challenging to detect small and/or perivascular focal liver metastases. Moreover, both metastases and benign cavernous hemangiomas appear hypointense and may be difficult to distinguish from one another. In this study we compared hepatobiliary phase MRI for detection and characterization of liver lesions by using an intravascular gadolinium based contrast agent, gadofosveset trisodium, in addition to gadoxetic acid in 78 patients with suspected metastases or hemangiomas. Our results revealed that combined gadoxetic acid and gadofosveset enhanced liver MRI improves liver lesion detection and characterization when compared to gadoxetic acid alone.

3 0840.
Adipose Tissue Hydration as a Potential Non-invasive Marker for Adipose Tissue Hypertrophy
Navin Michael1, Suresh Anand Sadananthan1, Jadegoud Yaligar2, Swee Shean Lee2, Melvin Khee-Shing Leow1,3, Chin Meng Khoo4, Eric Yin Hao Khoo4, Kavita Venkataraman5, Yung Seng Lee1,6, Yap Seng Chong1,7, Peter D. Gluckman1, E. Shyong Tai4, and S. Sendhil Velan2,8
1Singapore Institute for Clinical Sciences, A*STAR, Singapore, 2Singapore BioImaging Consortium, A*STAR, Singapore, 3Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 4Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 6Department of Paediatrics, Yong Loo Lin School of Medicine, Singapore, 7Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, Singapore, 8Clinical Imaging Research Centre, A*STAR, Singapore

The ability to measure adipose hypertrophy in vivo is relevant to better understand the pathophysiology involved in type 2 diabetes. Traditionally, adipose tissue hypertrophy has been assessed directly by histological examination of adipose tissue explants which is invasive and inconvenient to carry out in large cohort studies. The current work investigates the use of adipose tissue hydration, as measured using 1H MRS based hydrolipidic ratio, as a noninvasive marker of adipose tissue hypertrophy, and its association with serum metabolic parameters, insulin sensitivity, BMI, adipose depot volumes and ectopic fat infiltration in liver and skeletal muscle.

4 0841. Modelling skull dynamics during brain magnetic resonance elastography to evaluate wave delivery strategies
Deirdre M McGrath1,2, Alejandro F Frangi1, Iain D Wilkinson2, and Zeike A Taylor1
1CISTIB, Center for Computational Imaging & Simulation Technologies in Biomedicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom,2Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Magnetic resonance elastography (MRE) is currently being explored as a biomarker of neurodegenerative disease including dementia. A difficulty for this process of evaluation is that the measures of biomechanical properties obtained for healthy brain using MRE have varied widely. However the methodology has not been consistent between studies, such as wave frequency and the means of wave delivery. In this work an initial evaluation of has been made of a method to simulate skull vibration dynamics during MRE, to compare the impact of delivering the waves from different positions on the skull.

5 0842. Isocaloric Fructose Restriction for 10 Days Reduces MR-Measured Liver, Pancreatic and Visceral Fat in High Sugar-consuming, Obese Children
Susan M Noworolski1, Kathleen Mulligan2, Natalie Korn1, Molly Gibson1, Viva W Tai2,3, Michael Wen2, Ayca Erkin-Cakmak4, Alejandro Gugliucci5, Robert H Lustig4, and Jean-Marc Schwarz6
1Radiology & Biomedical Imaging, University of California, San Francisco, California, United States, 2Medicine, University of California, San Francisco, California, United States, 3CTSI-CRS, University of California, San Francisco, California, United States, 4Pediatrics, University of California, San Francisco, California, United States, 5Research, Touro University College of Osteopathic Medicine, Vallejo, California, United States, 6Basic Science, Touro University College of Osteopathic Medicine, Vallejo, California, United States

Thirty-six obese African American and Latino high-sugar consuming children underwent a 10-day isocaloric, fructose/sugar-restricted diet. Liver, pancreatic, visceral fat (VAT), and subcutaneous fat (SAT) were measured at baseline and 10 days later using MRS and Dixon-type imaging at 3T. The liver fat fraction decreased 29.5% ± 23% (p<0.001). Pancreatic fat fraction was lower in 74% (20/27) participants (p<0.05) with varied amounts of decrease. VAT decreased 6.9% ± 14% (p<0.006) while SAT did not change significantly. Subjects lost 1.1 ± 1.2% of body weight during the study. Decreases in MR-measured fat remained significant after adjustment for this minor weight loss.

6 0843. The Effect of Parallel Radiofrequency Transmission on Arterial Input Function Selection in 3T DCE-MRI of Prostate Cancer
Hatim Chafi1, Saba N Elias2, Huyen T Nguyen2, Harry T Friel3, Michael V Knopp2, BeiBei Guo4, Steven B Heymsfield5, and Guang Jia1
1Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, United States, 2Department of Radiology, The Ohio State University, Columbus, Ohio, United States, 3Clinical Science Operations, Philips Healthcare, Highland Heights, Ohio, United States, 4Department of Experimental Statistics, Louisiana State University, Baton Rouge, Louisiana, United States, 5Metabolism - Body Composition, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

18 prostate cancer patients underwent DCE-MRI scans on a 3T scanner) using a single channel RF transmit Q-body and 32-channel phased-array surface coils, while 21 patients were imaged on the same scanner with a parallel RF transmission upgrade. Comparison of baseline signal and signal enhancement in the left and right femoral arteries, indicates that baseline signals and signal enhancement are significantly more symmetrical. High field (3.0 T) MRI scanners equipped with multiple-channel parallel RF transmission enhances the symmetry of arterial input function in femoral arteries resulting in more consistent and homogeneous quantitative pharmacokinetic modeling in DCE-MRI of prostate cancer.

7 0844. Automatic combined whole-body muscle and fat volume quantification using water-fat separated MRI in postmenopausal women
Janne West1,2, Thobias Romu2,3, Anna-Clara Spetz Holm4, Hanna Lindblom1, Lotta Lindh-Åstrand4, Magnus Borga2,3, Mats Hammar4, and Olof Dahlqvist Leinhard1,2
1Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 2Center for Medical Imaging Science and Visualization, Linköping, Sweden, 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 4Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

Quantitative and exact measurements of fat and muscle in the body are important when addressing some of the greatest health-challenges today. In this study whole-body combined regional muscle and fat volume quantification was validated in a group of postmenopausal women, where the body composition is changing. Twelve subjects were scanned with a 4-echo 3D gradient-echo sequence. Water and fat image volumes were calculated using IDEAL, and image intensity correction was performed. Subsequently, automatic tissue segmentation was established using non-rigid morphon based registration. Whole-body regional fat and muscle segmentation could be performed with excellent test-retest reliability, in a single 7-minutes MR-scan.

8 0845. Stimulated Echo Diffusion Weighted Imaging of the Liver at 3T
Hui Zhang1, Aiqi Sun1, Xiaodong Ma1, Zhe Zhang1, Ed X. Wu2,3, and Hua Guo1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 3Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

Diffusion-weighted imaging (DWI) has been increasingly used in clinical applications due to its sensitivity to microscopic motion in biologic tissue. However, the DW signal depends on not only b-value but also the diffusion time due to restricted diffusion phenomenon. This work proposed an optimized stimulated-echo (STE) DWI method and aimed to investigate the dependence of diffusion measurement on diffusion time in healthy human liver. The results show that restricted diffusion behavior is observed in human liver at 3T, which demonstrates the effect of both b-value and diffusion time on liver DWI quantification.

9 0846. Characterizing Water Diffusion and Perfusion Features of the Healthy and Malignant Pancreas Using Diffusion-Tensor and Diffusion Weighted MRI
Noam Nissan1, Talia Golan2, Edna Furman-Haran1, Sara Apter2, Yael Inbar2, Arie Ariche2, Barak Bar Zakay2, Yuri Goldes2, Michael Schvimer2, Dov Grobgeld1, and Hadassa Degani1
1Weizmann Institute of Science, Rehovot, Israel, 2Sheba Medical Center, Israel

The diagnostic utility of 3T abdomen-MR DTI using b-values (0,100,500) and multi-b DWI were investigated in the healthy pancreas and pancreatic adenocarcinoma. Analysis of the DTI and DWI suggested a contribution of IVIM to the diffusion coefficient of the healthy pancreas at b<100 s/mm2 leading to a significant reduction in the diffusion coefficients and increase in FA at b-values of 100-500s/mm2 compared to 0-500 s/mm2. Cancer was characterized by lower diffusion coefficients in both b-sets and a smaller difference in these coefficients between the two sets, suggesting high cellularity and decreased perfusion, compared to normal pancreatic tissue.

10 0847. Utility of combined Ga-68 DOTA-TOC PET and Eovist MRI utilizing PET/MRI
Thomas A Hope1, Carina Mari Aparici1, Eric Nakakura2, Henry VanBrocklin1, Miguel Hernandez Pampaloni1, James Slater1, Salma Jivan1, Judy Yee1, and Emily Bergsland3
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Department of Surgery, UCSF, San Francisco, CA, United States,3Department of Medicine, UCSF, San Francisco, CA, United States

We have evaluated the combined modality PET/MRI for imaging of patients with hepatic metastasis from neuroendocrine tumor. Patients were imaged using Ga-68 labeled DOTA-TOC in conjuction with gadoxetate disodium as an MR contrast agent. Preliminary data demonstrates that PET/MRI is at least equivalent to PET/CT, with likely improved detection of hepatic lesions on hepatobiliary phase imaging.

11 0848. Imaging of Dissolved-phase Hyperpolarized Xenon-129 in Human Kidneys
John P. Mugler, III1, G. Wilson Miller1, Craig H. Meyer2, Kun Qing1, Jaime F. Mata1, Steven Guan2, Kai Ruppert1,3, Iulian C. Ruset4,5, F. William Hersman4,5, and Talissa A. Altes1
1Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 3Cincinnati Children's Hospital, Cincinnati, OH, United States, 4Xemed, LLC, Durham, NH, United States, 5Physics, University of New Hampshire, Durham, NH, United States

The purpose of this work was to determine if 129Xe can be detected in human abdominal organs, such as the kidneys. Dissolved-phase 129Xe imaging was performed at 1.5T in two healthy subjects. Dissolved-phase 129Xe was seen in the kidneys of both subjects, and a linear structure, consistent with the position of the descending aorta, was seen passing between the kidneys and bifurcating below the kidneys. These results may be of interest for kidney perfusion imaging. In addition, if multiple 129Xe resonances can be detected in the kidneys, dissolved-phase 129Xe imaging may offer additional interesting information on kidney function and disease.

12 0849.
Renal Blood Oxygenation Level-Dependent Imaging in Longitudinal Follow-up of the Donated and the Remaining Kidney in Renal Transplantation
Maryam Seif1, Ute Eisenberger2, Tobias Binser1, Harriet C Thoeny3, Fabienne Krauer1, Chris Boesch1, Bruno Vogt4, and Peter Vermathen1
1Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 2Dept. Nephrology, University Hospital Essen-Duisburg, Essen, Germany,3Dept. Radiology, Neuroradiology and Nuclear Medicine, University Hospital of Bern, Bern, Switzerland, 4Dept. Nephrology, Hypertension and Clinical Pharmacology, University Hospital of Bern, Bern, Switzerland

We determined renal oxygenation changes associated with uninephrectomy and transplantation in both, remaining and transplanted kidneys using blood oxygenation level-dependent (BOLD) MRI. Thirteen healthy kidney donors and their corresponding recipients underwent kidney BOLD MRI. BOLD MRI was performed in donors before uninephrectomy and in donors and recipients at day 8, month 3 and 12 after transplantation. BOLD MRI detects increased oxygen content in the remaining kidney of living kidney donors as very early adaptation to transplantation of the contralateral kidney. In contrast, the oxygen content in the transplanted kidney remains very constant.

13 0850. Redistribution of Fractional Ventilation after Circumscribed Primary Lung Injury and Atelectasis
Yi Xin1, Maurizio Cereda2, Hooman Hamedani1, Harrilla Profka1, Justin Clapp1, Stephen Kadlecek1, Brian P. Kavanagh3, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 3Hospital for Sick Children, Toronto, Ontario, Canada

Atelectasis and mild local lung injury cause redistribution of inspired gas to residual ventilated airspaces, resulting in their over-ventilation and potentially damaging ventilatory stress. This dynamic can be spatially evaluated by hyperpolarized 3He imaging. Hyperpolarized 3He maps of fractional ventilation (r) demonstrate that recruitment with PEEP attenuates residual over-ventilation in HCl models of circumscribed lung injury.

14 0851.
Three-Dimensional Pulmonary 1H MRI Multi-Region Segmentation Using Convex Optimization
Fumin Guo1,2, Sarah Svenningsen1,3, Aaron Fenster1,2, and Grace Parraga1,2
1Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2Graduate Program in Biomedical Engineering, The University of Western Ontario, London, Ontario, Canada, 3Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada

Many applications of pulmonary 1H MRI require lung cavity segmentation as a prerequisite. Accordingly, we proposed a convex optimization based approach to simultaneously segment the right and left lungs from pulmonary 1H MRI in 3D. Our approach employs the latest developments in convex optimization techniques and solves the original challenging optimization problem globally and exactly under the primal and dual perspective. We implemented the algorithm in a modern parallel computing platform and applied it to a clinical dataset of ten COPD subjects. Our experimental results demonstrate that this computationally efficient method yields highly accurate lung volumes with minimal user interaction.

15 0852.
Ventilation heterogeneity in obstructive airways disease – comparing multi-breath washout-imaging with global lung measurements
Felix C Horn1, Helen Marshall1, Salman Siddiqui2, Alexander Horsley3, Laurie Smith1, Ina Aldag4, Richard Kay5, Christopher J Taylor4, Juan Parra-Robles1, and Jim M Wild1
1Sheffield University, Sheffield, United Kingdom, 2University of Leicester, United Kingdom, 3University of Manchester, United Kingdom, 4Sheffield Children's NHS Foundation Trust, NHS, United Kingdom, 5Novartis, Switzerland

Gas washout measured with hyperpolarized helium-3 MRI can be used to obtain quantitative regional lung function in 3D (MBW-I). Multiple breath inert gas washout as clinically performed in the pulmonary function lab (MBW) is sensitive to early signs of ventilation heterogeneity in obstructive lung diseases. In this work MBW-I and MBW were performed in healthy controls, CF patients and an asthma cohort. Ventilation heterogeneity as measured by MBW-I was found to correlate significantly with MBW & spirometry. The MBW-I derived parameter to measure ventilation heterogeneity was found to be more sensitive to ventilation heterogeneity than conventional MBW and spirometry.