ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Multiple Sclerosis 1

Thursday 4 June 2015

John Bassett Theatre 102

10:30 - 12:30


T.B.A., T.B.A.

10:30 0819.   Reduced specific absorption rate (SAR) Magnetization Transfer imaging with Low Density MT pulse technique for 7 Tesla
Se-Hong Oh1, Wanyong Shin1, and Mark J Lowe1
1Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States

Due to the much higher specific absorption rate (SAR) of tissue at ultra-high field (UHF), the acquisition time of MT imaging at UHF is much longer than at lower filed strengths. Thus, MT imaging at UHF MRI has not, heretofore been suitable for clinical scanning. In this work, we described a new MT acquisition technique within a clinically reasonable time (<6 min) which uses a sparsely applied MT pulse. With new proposed MT acquisition scheme, the scan time is reduced considerably while maintaining similar MTR when compared with the case of conventional MT.

10:42 0820.   
High resolution MR elastography reveals disseminated white matter degradation of brain tissue integrity in clinically isolated syndrome
Andreas Fehlner1, Kaspar-Josche Streitberger1,2, Friedemann Paul3,4, Jens Würfel3,5, Jürgen Braun6, and Ingolf Sack1
1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Neurology with experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 5Institute of Neuroradiology, Universitätsmedizin Göttingen, Göttingen, Germany, 6Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

High resolution multifrequency MR elastography (MMRE) was applied to patients with clinical isolated syndrome (CIS) in order to test if white matter viscoelasticity is significantly affected by a single neurological episode of inflammation or demyelination. On average, we observed a significant reduction of the magnitude of the complex shear modulus (~11%, p = 0.001) in 17 CIS patients compared to healthy controls. This study complements previous findings on the gradual mechanical degradation of brain tissue associated with multiple sclerosis and raises the prospect of using MMRE as an early marker of neuroinflammation and demyelination.

10:54 0821.   Ultra-high field MRI longitudinal MS lesion study
Bryson Dietz1, David A Rudko2, Marcelo Kremenchutzky3, and Ravi S Menon1,4
1Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, ON, Canada, 2Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 3London Health Sciences Centre, London, ON, Canada, 4Department of Medical Biophysics, Western University, London, ON, Canada

Longitudinal ultra-high field MR imaging was conducted on 16 relapse remitting multiple sclerosis (RRMS) patients, along with 16 age-matched controls. Lesions were investigated temporally using quantitative susceptibility mapping (QSM) and R2* quantitative imaging. For ringed lesions, we upsampled the image and separated the ring from the inner lesion core, to evaluate each separately. We found that lesion ring and inner core behave similarly over time, which indicates they both respond similarly to biological changes occurring within the tissue. We found R2* to slowly decrease as lesions form, whereas QSM has a sudden jump in susceptibility.

11:06 0822.   Beyond focal cortical lesions in multiple sclerosis: an in vivo quantitative and spatial imaging study at 7 T
Céline Louapre1,2, Sindhuja T Govindarajan1, Costanza Gianně1,2, Jacob A Sloane3, RP Kinkel4, and Caterina Mainero1,2
1AA. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Beth Israel Deaconess Medical Center, Boston, MA, United States, 4University of California San Diego, San Diego, CA, United States

We investigate 7 T T2* relaxation rates in the cortex of subjects with multiple sclerosis (MS) to determine: 1) quantitative T2* changes in and beyond visible focal cortical lesions (CL), 2) the spatial distribution of focal MS CL across the cortex, 3) the impact of focal CL on the surrounding peri-lesional cortex. MS focal CL exhibit longer T2* than healthy cortex. Quantitative T2* changes extend beyond visible CL in progressive MS. Cortical lesions, however, have the same impact on surrounding peri-lesional cortex across disease stages.

11:18 0823.   
Multivariate combination of magnetization transfer ratio and quantitative T2* to detect subpial demyelination in multiple sclerosis
Gabriel Mangeat1,2, Sindhuja Tirumalai Govindarajan2, Revere Philip Kinkel3, Caterina Mainero2,4, and Julien Cohen-Adad1,5
1Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Qc, Canada, 2Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, 3Clinical Neurosciences, University of California San Diego, La Jolla, CA, United States, 4Harvard Medical School, Boston, MA, United States,5Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, Qc, Canada

We introduce a multivariate statistical framework for combining cortical sampling of MTR and T2* to gain specificity for mapping cortical myelin content. (i) We sampled cortical MTR and T2* from Freesurfer segmentation. (ii) we normalized MTR and T2* maps and corrected them for partial volume effect and B0 orientation. (iii) we extracted the shared myelin information using a spatial independent component analysis. We demonstrate the benefits of this framework for separating healthy controls from subject with multiple sclerosis on the basis of cortical pathology.

11:30 0824.   Advanced Myelin Water Imaging Techniques for Rapid Data Acquisition and Long T2 Component Measurements
Jing Zhang1, Irene Vavasour1, Shannon Kolind2, Baumeister Baumeister3, Alexander Rauscher1, and Alex L. MacKay1,4
1Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 2Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 3Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada,4Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada

Myelin water fraction (MWF) is conventionally measured using the T2 decay curve.In this work, GRASE T2 decay curves were performed with different TEs and numbers of echoes for six healthy subjects. These sequences permit more applications for myelin water imaging in clinical studies and neuroscience.

11:42 0825.   Voxel-based analysis of subcortical grey matter using transverse relaxation and quantitative susceptibility mapping: application to multiple sclerosis
Dana Cobzas1, Hongfu Sun1, Andrew J. Walsh1, R. Marc Lebel1, Gregg Blevins2, and Alan H. Wilman1
1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, 2Neurology, University of Alberta, Edmonton, Alberta, Canada

Quantitative Susceptibility Mapping (QSM) and R2* mapping studies of subcortical grey matter have generally analyzed large regions-of-interest that do not supply precise location of iron accumulation. Large regions have been used partly due to the difficulty of accurate segmentation of deep grey matter. Here we develop a focused deep grey nuclei atlas using combined QSM and T1-weighted images and investigate its precision and reliability for voxel-based subcortical grey matter analysis using R2* and QSM. We then apply our method to multiple sclerosis to determine local effects of iron accumulation in subcortical grey matter nuclei.

11:54 0826.   Regional white matter abnormalities and cognitive impairment in MS: a multicenter TBSS study - permission withheld
Elisabetta Pagani1, Maria A. Rocca1,2, Alvino Bisecco1, Olga Ciccarelli3, Christian Enzinger4, Antonio Gallo5, Hugo Vrenken6, Maria Laura Stromillo7, Tarek A. Yousry3, Franz Fazekas4, Gioacchino Tedeschi5, Frederik Barkhof6, Nicola De Stefano7, Massimo Filippi1,2, and the MAGNIMS Network8
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 2Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 3UCLH NHS Foundation Trust, National Hospital for Neurology and Neurosurgery, London, UK, United Kingdom, 4Department of Neurology, Medical University of Graz, Graz, A, Austria, 5MRI Center “SUN-FISM", Second University of Naples, Naples, NA, Italy, 6Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands, Netherlands, 7Department of Neurological and Behavioral Sciences, University of Siena, Siena, SI, Italy, 8EU, EU, Italy

Single center studies have shown an association between disrupted white matter architectural integrity and clinical manifestations, including cognitive impairment, in multiple sclerosis (MS). In this study, we applied voxel wise analysis of diffusion tensor derived metrics in data obtained in a multi-center setting to assess the spatial distribution of white matter damage in MS and its relationship with cognitive impairment. We found significant differences comparing cognitive impaired with cognitive preserved patients and correlations with cognitive tests. We concluded that this approach is feasible in a multi-center setting and it contributes to better characterize disease related cognitive manifestations.

12:06 0827.   
Cognitive status of multiple sclerosis patients is associated with neocortical neuronal injury: A voxel-based sodium MRI study
Adil Maarouf1,2, Bertrand Audoin1, Anthony Faivre1, Francoise Reuter1, Fanelly Pariollaud1, Audrey Rico1, Elisabeth Soulier1, Sylviane Confort-Gouny1, Maxime Guye1, Lothar Schad3, Jean Pelletier1, Jean-Philippe Ranjeva1, and Wafaa Zaaraoui1
1CRMBM UMR CNRS 7339 Aix-Marseille Université, Marseille, France, 2Faculté de Médecine, Université de Reims Champagne-Ardenne, Reims, France,3Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany

This study aimed to assess brain sodium accumulation in cognitive MS. Fifty-eight patients and 31 controls were included in a sodium MRI study performed at 3T. Total sodium concentration (TSC) was increased in cognitive MS patients compared to non-cognitive MS patients and controls. These sodium accumulations were located in the cingulate cortex, precuneus, temporal and prefrontal cortices, independently of atrophy. In cognitive MS, sodium accumulation, which is an indicator of neuronal injury, affects the neocortex (involved in higher functions). Sodium MRI is able to depict neuronal injury, very early in the disease, before the occurrence of atrophy.

12:18 0828.   
High Contrast Magnitude And Phase Imaging of the Short T2 Components in White Matter of the Brain
Qun He1, Lanqing Ma1, Wen Hong1,2, Vipul Sheth1, Graeme M Bydder1, and Jiang Du1
1Radiology, UC, San Diego, San Diego, CA, United States, 2Radiology, China-Japan friendship hospital, Beijing, Beijing, China

IR-UTE sequence was employed to generate high contrast magnitude and phase images of the previously undetected short T2 components in white matter of the brain in vivo using a clinical 3T scanner.