ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Bone & UTE

Thursday 4 June 2015

Room 714 A/B

16:00 - 18:00


Jiang Du, Ph.D., T.B.A.

16:00 0932.   
Bound Bone Water Density is a Surrogate Measurement of Organic Matrix Density
Alan C. Seifert1, Cheng Li1, Suzanne L. Wehrli2, and Felix W. Wehrli1
1University of Pennsylvania, Philadelphia, PA, United States, 2Children's Hospital of Philadelphia, Philadelphia, PA, United States

Proton NMR signal in bone arises from pore water (T2 > 1ms), bound water (T2 ~ 400±100µs), and collagen (T2 << 100µs). Pore water is hypothesized to scale with porosity, and bound water with collagen density. Here we measured single adiabatic inversion-recovery zero echo-time (SIR-ZTE) bound water density in 15 human cortical bone specimens at 9.4T, and found strong correlations with both gravimetric organic matrix density (R^2 = 0.74) and µCT porosity (R^2 = 0.73). SIR-ZTE is therefore suitable for measurement of matrix density in vivo.

16:12 0933.   
In vivo imaging of bound and pore water in tibia and femur using 3D Cones sequences
Jun Chen1, Michael Carl2, Hongda Shao1, Soorena Azam Zanganeh1, Eric Chang1,3, Christine B Chung1,3, Graeme M Bydder1, and Jiang Du1
1Radiology, University of California, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States, 3Department of Radiology, VA San Diego Healthcare System, San Diego, CA, United States

Bound and pore water have been reported to make different contributions to the mechanical properties of cortical bone. By using Ultrashort echo time (UTE) sequences signals from both bound and pore water can be detected in cortical bone. In this study, tibial and femoral mid-shafts in healthy volunteers were respectively imaged with 3D Cones and 3D IR-Cones sequences, to measure T1 and T2* of bound and pore water at both sites, and to investigate whether there are differences between these two sites. High resolution imaging of the tibia and fermur can be achieved. The femoral midshaft and tibial midshaft have different MR properties, including bound and pore water T2*s, relative fractions, effective T1 of both bound and pore water, and T1 of bound water.This study suggests that T1 and T2* of bound and pore water in cortical bone can be measured with 3D Cones and IR-Cones sequences; femoral and tibial midshafts may have different properties in healthy volunteers.

16:24 0934.   Bone Marrow Fat Quantification in calcaneus. Why not?
Silvia Capuani1,2, Giulia Di Pietro2,3, Guglielmo Manenti4, Vincenzo Vinicola5, Marco Bozzali6, and Umberto Tarantino7
1Physics Department, CNR-IPCF Roma Sapienza University of Rome, Rome, Italy, Italy, 2Center for Life NanoScience@LaSapienza, Istituto Italiano di Tecnologia, Rome, Italy, Italy, 3Enrico Fermi Center, Rome, Italy, Italy, 4Department of Diagnostic Imaging and Interventional Radiology, “Tor Vergata” University of Rome, Rome, Italy, Italy, 54Rehabilitation Hospital IRCCS Santa Lucia Foundation, Rome, Italy, Rome, Italy, Italy, 6Neuroimaging Laboratory Santa Lucia Foundation, Rome, Italy, Italy, 75Department of Orthopaedics and Traumatology, PTV Foundation, “Tor Vergata” University of Rome, Rome, Italy, Italy

The investigation of calcaneus bone-marrow might offer the chance of reducing the risk of subjects’ claustrophobic reactions, which remains a major source of drop-outs in Magnetic Resonance (MR) examinations. In this work the reliability and the potential of MR Spectroscopy in calcaneus is discussed. MRS in calcaneus can provide reliability fats estimation and L13/L43, L13/L52+L53 may be reliable markers of osteoporosis. Since bone-marrow fats in calcaneus are characterized by a different metabolism compared to that of vertebral or femoral sites, MRS in calcaneus performed in large population, may increase our pathophysiological understanding of osteoporosis from a metabolic point of view.

16:36 0935.   UTE Imaging With Simultaneous Water and Fat Signal Suppression Using An Efficient Multi-Shot Inversion Recovery Preparation
Michael Carl1, Jiang Du2, and Graeme M Bydder2
1GE Healthcare, San Diego, CA, United States, 2UCSD, CA, United States

In this work we explore the collection of several UTE k-space spokes after the application of a single IR pulse. Theoretical calculations, simulations, and phantom experiments were used to optimize the sequence parameters such as TI and flip angle.

16:48 0936.   Dental MRI can detect micro-cracks
Djaudat Idiyatullin1, Michael Garwood1, and Donald Nixdorf2
1CMRR, Radiology Department, University of Minnesota, Minneapolis, Minneaota, United States, 2Division of TMD & Orofacial Pain and Department of Neurology, University of Minnesota, Minneapolis, Minneaota, United States

This work demonstrates that dental MRI using SWIFT identifies cracks of about 20 μm thickness and larger, which is one order of magnitude smaller than the image voxel, within the dentin of teeth. To explain this phenomenon, a dental digital MRI model based on known 1H relaxation parameters in dental tissues is proposed. The comparison of simulated and experimental data helps to understand the mechanisms of contrast observed in SWIFT images of cracked teeth. The similarity of dentin and cortical bone allows the generalization of the proposed model for studies other bone pathologies.

17:00 0937.   Feasibility of Ultrashort Echo Time (UTE) MR Imaging at 1.5 T in the Diagnosis of Skull Fractures
Hao Wu1, Shuguang Chu1, Huaping Sun1, Yumin Zhong2, Quanmin Nie3, Liemei Guo3, Xi Yang3, Hong Zhang2, Yi Lin2, Weibo Chen4, He Wang5, and Ming Zhu2
1Department of Radiology, HuaShan Hospital North, Fudan University, Baoshan District, Shanghai, China, 2Department of Radiology, Shanghai Children¡¯s Medical Center, Shanghai Jiao Tong University School of Medicine, Pudong New District, Shanghai, China, 3Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong New District, Shanghai, China, 4Philips Healthcare, Shanghai, China, 5Philips Research China, Shanghai, China

By the research of skull fracture specimens of 10 Bama pigs and 45 skull fracture patients, our study firstly found that MRI three dimentional ultrashort echo time (UTE) dual-echo pulse sequences clearly demonstrated the skull structures and fractures including linear, depressed and comminuted fractures. On this basis, the head MRI scan sequences of paediatric and adult patients of craniocerebral trauma, will be designed to partly replace CT to achieve the goal of no radiation and accurate imaging diagnosis. Particularly, the infants, children and pregnant women who are sensitive to or prohibited from X-ray will benefit from this study.

17:12 0938.   
Quantitative susceptibility mapping of bone using ultra-short TE sequence
Alexey V. Dimov1,2, Zhe Liu1,2, Pascal Spincemaille2, Jiang Du3, and Yi Wang1,2
1Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States, 2Radiology Department, Weill Cornell Medical College, New York, New York, United States, 3University of California (San Diego), California, United States

In the current work we us an ultrashort echo time (UTE-GRE) pulse sequence for MR signal acquisition and field map estimation within the bones; preliminary results demonstrate CT-quality quantitative susceptibility mapping of bone using the proposed technique both ex- and in-vivo.

17:24 0939.   
MRS-based vertebral bone marrow fat quantification using prior fat spectrum characterization and T2 correction
Michael Dieckmeyer1, Stefan Ruschke1, Christian Cordes1, Samuel Paran Yap1, Hendrik Kooijman2, Hans Hauner1, Ernst J. Rummeny1, Jan S. Bauer1, Thomas Baum1, and Dimitrios C. Karampinos1
1Technische Universität München, Munich, Germany, 2Philips Healthcare, Germany

MRS-based vertebral bone marrow fat quantification is confounded by the overlapping of water and fat peaks and the differences in T2 relaxation times of water and fat. The purpose of the present study was to determine using single-voxel MRS the vertebral bone marrow proton density fat fraction (PDFF) using single-voxel MRS, addressing the confounding effects introduced by overlapping water-fat peaks and the difference in T2 relaxation time between the water and fat components. The importance of the consideration of T2 decay effects in bone marrow fat quantification was shown in the context of the analysis of the bone marrow fat fraction age dependence.

17:36 0940.   Dual Echo UTE Imaging with Rescaled Subtraction (dUTE-RS): Scaling Factor Optimization Study
Yanchun Zhu1, Jiang Du2, Qun He2, Shanglian Bao3, Song Gao3, Guoru Zhao1, and Yaoqin Xie1
1Institue of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China, 2Department of Radiology, University of California, California, United States, 3Beijing City Key Lab of Medical Physics and Engineering, Peking University, Beijing, China

Dual Echo UTE Imaging with Rescaled Subtraction (dUTE-RS): Scaling Factor Optimization Study

17:48 0941.   Selective Musculoskeletal MRI Using ZTE Imaging with Long-T2 Suppression
Markus Weiger1, Mingming Wu1,2, Moritz Christoph Wurnig3, David Kenkel3, Andreas Boss3, Gustav Andreisek3, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany, 3Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

Zero echo time (ZTE) imaging enables direct MRI of tissues with rapid relaxation, such as e.g. bone, tendons, or ligaments. Yet the feature of detecting signals from a wide T2 range is accompanied by a lack of contrast between the corresponding tissues. Therefore, in this work, efficient long-T2 suppression is developed for the ZTE technique. In this way, selective, direct musculoskeletal MRI akin to CT contrast is enabled and demonstrated in a tissue sample.