ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Normal Brain Anatomy & Morphometry

Thursday 4 June 2015

John Bassett Theatre 102

16:00 - 18:00


Andrew L. Alexander, Ph.D., David J. Mikulis, M.D.

16:00 0962.   Influence of T1 contrast and resolution on myelinated cortical thickness at 7 Tesla
Pierre-Louis Bazin1, Christine Lucas Tardif1, Arno Villringer1, and Nicholas Bock2
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2McMaster University, Ontario, Canada

This work studies a newly proposed morphometric measurement in the cerebral cortex, the myelinated thickness and myelinated thickness ratio, in the context of high resolution 7 Tesla imaging. A new algorithm for myelinated thickness estimation is proposed, and the measures extracted from T1-weighted and quantitative T1 contrasts are compared at multiple resolutions.

16:12 0963.   Enhanced T1-weighted myelin contrast across lamina at 7T; in-vivo, ex-vivo, and histology
Alessio Fracasso1, Susanne J van Veluw2, Fredy Visser3,4, Jaco JM Zwanenburg4, Serge O Dumoulin1, and Natalia Petridou4
1Experimental Psychology, Helmholtz institute, Utrecht University, Utrecht, Netherlands, 2Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, Netherlands, 3Philips Medical Systems, Best, Netherlands, 4Radiology, Imaging Division, University Medical Center, Utrecht, Netherlands

Myelin content can be estimated in vivo to identify a large number of cortical areas, however extra-striate, within-area myelination at sub-mm scale is harder to visualize. Using a modified T1-w MPRAGE we visualize striate and extra-striate laminar intensity variations in in-vivo and ex-vivo data, comparing ex-vivo results with histological sections. In-vivo, ex-vivo and histology striate areas as well extra-striate cortex showed a reliable, high-contrast structure around the middle of cortical thickness in T1-w laminar profiles. This structure likely represents the two separated lines of Baillarger. This T1-w sequence provides the basis for studying laminar structure in humans, in vivo.

16:24 0964.   
MR Morphometry of Myeloarchitecture for In-vivo Cortical Mapping
Christine Lucas Tardif1, Nicholas A Bock2, Arno Villringer1, and Pierre-Louis Bazin1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany, 2McMaster University, Hamilton, Ontario, Canada

We present a novel intra-cortical boundary estimated from high-resolution T1 images where cortical layer structure is visible. The boundary between deeper myelinated cortical layers and more superficial ones can be used to derive two morphometric measures of local myeloarchitecture: myelinated cortical thickness and myelinated thickness ratio. We compare group averages of these two contrasts to T1 and total cortical thickness, and discuss their relevance to brain mapping and plasticity studies.

16:36 0965.   Effect of hypobaric pressure on MRI parameters, including B0, T2, T2*, and T1
Eric R. Muir1, Damon P. Cardenas1, and Timothy Q. Duong1
1Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States

High-altitude, where air pressure and thus oxygen content are reduced, could lead to a broad spectrum of disorders in the brain, such as white matter hyperintensity and brain swelling. Previous studies investigated high altitude sickness post exposure. Studies of the brain during hypobaric conditions could lead to a better understanding of its effects. In this work, we constructed an MRI-compatible hypobaric chamber for animal MRI scanner and performed B0 and relaxation time measurements during acute hypobaric exposure. B0 was slightly shifted under hypobaric pressure, and T2 and T2* were decreased under hypobaric air.

16:48 0966.   
Connectivity-based atlas of human brain white matter in ICBM-152 space.
Anna Varentsova1, Shengwei Zhang2, Ekaterina Shanina1, and Konstantinos Arfanakis2,3
1Physics Department, Illinois Institute of Technology, Chicago, IL, United States, 2Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 3Rush Alzheimer's Disease Center, Rush University, Chicago, IL, United States

Digital human brain atlases consisting of MRI-based templates and semantic labels delineating different brain regions serve a critical role in neuroimaging, mainly facilitating spatial normalization and automated segmentation, for the purposes of voxel-wise, region-of-interest, and network analyses. As part of the IIT Human Brain Atlas project (, we have recently developed, anatomical as well as state-of-the-art diffusion tensor and high angular resolution diffusion imaging (HARDI) templates, as well as probabilistic gray matter (GM) labels in ICBM-152 space. The purpose of this project was to construct the first probabilistic connectivity-based atlas of human brain white matter (WM) in ICBM-152 space.

17:00 0967.   Arcuate fasciculus delineation by means of diffusion compartment imaging based tractography
Xavier Tomas-Fernandez1, Benoit Scherrer1, Catherine Wan1, and Simon K. Warfield1
1Boston Children's Hospital, Boston, MA, United States

In this work, we evaluated the ability of tractography based in diffusion compartment imaging to recover the complete length of the arcuate fasciculus and compare it with that achieved by difussion tensor based tractography.

17:12 0968.   
The number of subjects needed to detect a change in white matter microstructure depends on the pathway in question
Sonya Bells1, C John Evans1, and Derek K Jones1
1School of Psychology, CUBRIC, Cardiff, Wales, United Kingdom

To be able to evaluate the differences in white matter across time plays an important role in brain research. We aim to estimate the sample size necessary to detect changes within white matter tracts in a repeated measures design. Three white matter sequences were acquired (diffusion weighted, multi-component relaxometry and non-Gaussian diffusion) to assess the variance within 18 different white matter tracts, which was then used in power calculations. Power calculations varied between the different white matter sequences and tracts. For example, detecting a 15% change within FA for the uncinate 18 subjects are needed while in cingulum-hippocampus it is 45.

17:24 0969.   Investigating variability of brain anatomy using three common mouse strains
Jan Scholz1, Matthijs van Eede1, Jason P Lerch1,2, and Mark Henkelman1,3
1Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Medical Biophysics, University of Toronto, ON, Canada

Investigating variability of brain anatomy using three common mouse strains.

17:36 0970.   
In vivo high resolution imaging of the mouse neurovasculature
Jérémie Pierre Fouquet1, Réjean Lebel1, Luc Tremblay1, and Martin Lepage1
1CIMS, Université de Sherbrooke, Sherbrooke, QC, Canada

A method allowing in vivo magnetic resonance imaging of the mouse neurovasculature at high resolution (<100 µm) is presented. It uses the Resovist contrast agent and a dedicated head coil. Images and extracted vessel sizes obtained in vivo are compared against ex vivo results obtained at the same resolution. A study of the vessels size distributions in three main regions of the brain is presented and used as a basis for the comparison.

17:48 0971.   Initial Human Imaging Experience with a Head-only Gradient System Utilizing 80 mT/m and 500 T/m/s
John Huston III1, Shengzhen Tao1, Joshua D. Trzasko1, Paul T. Weavers1, Yunhong Shu1, Erin Gray1, Seung-Kyun Lee2, Jean-Baptiste Mathieu2, Christopher J. Hardy2, John Schenck2, Ek Tsoon Tan2, Thomas K.F. Foo2, and Matt A. Bernstein1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2GE Global Research, Niskayuna, NY, United States

A second generation head-only gradient system with asymmetric transverse coils and all hollow-conductor coils was constructed and human volunteers imaged. Testing occurred inside a conventional whole-body 3T magnet to assess image quality and peripheral nerve stimulation (PNS). The gradient was integrated with a custom-built birdcage transmit/receive coil and a Nova 32-channel receiver array. Initial experience demonstrated high quality brain images with gradients performing at 80 mT/m and 500 T/m/s simultaneously while minimizing peripheral nerve stimulation. In addition, a novel integrated gradient nonlinearity correction strategy was found to improve in vivo images acquired on this system.