ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Translations MR Imaging of Musculoskeletal Physiology

Tuesday 2 June 2015

Room 716 A/B

10:00 - 12:00


Edwin H. G. Oei, M.D., Ph.D., T.B.A.

10:00 0309.   UTE 3D Cones Trajectory with T1lower case Greek rho weighted imaging for MSK applications - permission withheld
Robert Nikolov1, Michael Carl2, Eric Chang1,3, Christine Chung1,3, Graeme Bydder1, and Jiang Du1
1Radiology, University of California, San Diego, San Diego, California, United States, 2GE Healthcare, Waukesha, Wisconsin, United States, 3Radiology, VA San Diego Healthcare System, La Jolla, California, United States

In this study we demonstrate the use of a novel ultra short echo time (UTE) T1lower case Greek rho sequence that combines a three-dimensional cones sequence preceded by a spin-lock preparation pulse for T1lower case Greek rho contrast . T1lower case Greek rho contrast is compared between this 3D sequence and a 2D radial sequence for: i) spherical CuSO4 phantom ii) ex-vivo meniscus sample and iii) in-vivo imaging of the human knee joint. Meniscus and tibial plateau values are reported as 18+/- 4ms and 36+/-3 ms respectively. The SNR efficiency and reduced eddy current artifacts afforded by the 3D cones sequence provides a robust sequence within a clinical relevant imaging time.

10:12 0310.   A Mechanism for Quantifiable MRI-Based Detection of Cobalt-Chromium Particulate Deposits Near Total Hip Replacements
Kevin M Koch1, Matthew F Koff2, Parina Shah2, and Hollis G Potter2,3
1Biophysics and Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2Radiology and Imaging, Hospital for Special Surgery, NYC, NY, United States, 3Weill Cornell Medical College of Cornell University, NYC, NY, United States

Recent clinical patterns have shown an increasing trend of soft-tissue complications near total hip replacements, particularly those with metal on metal bearing surfaces. The presence of substantial metallic debris can highlight implant malfunction correlated to wear of the bearing surfaces. Metallic debris generates a resonance frequency shift that can be detected using MRI methods. Unfortunately, conventional image artifacts confound traditional methods for detailed frequency shift assessments near implants. Here, we demonstrate quantifiable image contrast highlighting cobalt-chromium particle deposits near metal implants using MAVRIC field maps and locally applied dipolar projection background field removal methods.

10:24 0311.   Direct Visualization of Cartilage Delamination in FAI at 3T using Multiband Acceleration
Jutta Ellermann1, Abraham Padua2, Edward Auerbach1, and Dingxin Wang1,3
1CMRR, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, United States, 2Siemens Healthcare, Houston, Texas, United States,3Siemens Healthcare, Minneapolis, Minnesota, United States

The utility for multiband accelerated TSE imaging was tested for FAI (Femoroacetabular Impingement), a common clinical indication for hip studies in young active patients. Conventional MR is limited in the assessment of hip cartilage due to insufficient resolution. Cartilage damage occurs deep within the tissue as a debonding from the acetabulum, a pattern uniquely ill suited for diagnosis with standard imaging at 3mm slice thickness. The overall acquisition time for this modified multiband accelerated TSE imaging protocol can be reduced and supplemented with dedicated sequences with increased slice resolution for improved diagnostic accuracy of cartilage delamination, the hallmark of FAI.

10:36 0312.   
Quantitative Assessment of the Normal and Abnormal Achilles Tendon in vivo Using a 3D Cones Sequence
Hongda Shao1, Michael Carl2, Eric Chang1, Christine B Chung1, Graeme M Bydder1, and Jiang Du1
1Radiology, University of California, San Diego, CA, United States, 2GE Healthcare, San Diego, CA, United States

Tendon is a highly ordered collagen-rich fibril tissue links muscle to bone. Multiple water components with distinct MR relaxation times exist in the tendon. In this study, we aimed to study the multiple water components in the Achilles tendon, and investigate its MTR as a function of MT pulse frequency offset in healthy volunteers and patients with tendon rupture using a clinical 3T scanner

10:48 0313.   High-Resolution 3D MR Neurography of the Wrist using Phase-Cycling Diffusion-Sensitized Driven-Equilibrium (pcDSDE)
Masami Yoneyama1, Makoto Obara1, Yuriko Ozawa2, Hajime Tanji3, Masanobu Nakamura1, Tomoyuki Okuaki1, Takashi Tabuchi2, Satoshi Tatsuno2, Ryuji Sashi2, and Marc Van Cauteren1
1Philips Electronics Japan, Tokyo, Japan, 2Yaesu Clinic, Tokyo, Japan, 3Imaging Center, Kita-Fukushima Medical Center, Fukushima, Japan

This study showed a new scheme for MR neurography of the wrist by using phase-cycled diffusion-sensitized driven equilibrium (pcDSDE) technique for achieving high-resolution MR neurography in the wrist. pcDSDE sequence clearly showed both anatomies and courses of median nerve, ulnar nerve and their branches. Furthermore, this sequence could offer gself-fusionh images simultaneously by using two types of reconstructed images (neurography images and anatomical images). DSDE sequence has great potential to stably depict peripheral nerves in the extremities.

11:00 0314.   
Removing the confounding effect of the fat component in ADC quantification of the vertebral bone marrow water component
Michael Dieckmeyer1, Stefan Ruschke1, Holger Eggers2, Hendrik Kooijman3, Ernst J. Rummeny1, Jan S. Bauer4, Thomas Baum1, and Dimitrios C. Karampinos1
1Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, 2Philips Research Laboratory, Hamburg, Germany, 3Philips Healthcare, Hamburg, Germany, 4Diagnostic and Interventional Neuroradiology, Technische Universität München, Munich, Germany

The quantification of the apparent diffusion coefficient (ADC) of water in vertebral bone marrow has shown merit towards differentiating between benign and malignant vertebral compression fractures and towards indirectly investigating bone matrix changes in patients with osteoporosis. Vertebral bone marrow contains both water and fat components. Therefore, the extraction of water ADC can be biased by incomplete fat suppression of the secondary fat peaks close to the water peak, when using a spectrally selective fat suppression technique. The present work proposes a methodology to correct for the confounding effect of incomplete fat suppression in bone marrow water ADC quantification.

11:12 0315.   
Assessment of Extracellular Matrix Degradation in Intervertebral Disc Degeneration by Diffusion Weighted MRS and Chemical Exchange Saturation Transfer
Anna M. WANG1,2, Adrian Tsang1,2, and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, Hong Kong, Hong Kong, Hong Kong, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong, Hong Kong

This study compared the capability of diffusion weighted MRS (DW-MRS) and chemical exchange saturation transfer (CEST) methods in detecting and characterizing the ECM degradation during the early stage of IVDD in an ex vivo model. The apparent diffusion coefficient (ADC) of glycosaminoglycan (GAG) increased drastically immediately after papain injection, while the GAG concentration measured by both MRS and CEST method shared a similar but slow decreasing trend which happened later than the GAG ADC increase. The GAG ADC value, which is free from the influence of the GAG concentration, is an important potential marker for detecting the onset of the ECM degradation in IVDD.

11:24 0316.   
T1ρ and T2-based quantitative technique for characterization of regional variations in intervertebral discs to detect early degenerative changes.
Prachi Pandit1, Martin Kretzschmar1, Valentina Pedoia1, William Dillon1, and Sharmila Majumdar1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

Regional variation of T1p and T2 values within the nucleus pulposa (NP) and annulus fibrosa (AF) of intervertebral discs (IVDs) has the potential of being a powerful biomarker for degenerative disc disease (DDD), much more so than just their mean values.

11:36 0317.   Assessment of glycosaminoglycan content in lumbar intervertebral discs with chemical exchange saturation transfer imaging: comparison with T1-rho measurement - permission withheld
Osamu Togao1, Akio Hiwatashi1, Tatsuhiro Wada2, Koji Yamashita1, Kazufumi Kikuchi1, Chiaki Tokunaga2, Yuriko Suzuki3, Jochen Keupp4, and Hiroshi Honda1
1Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan, 2Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Fukuoka, Japan, 3Philips Electronics Japan, Tokyo, Japan, 4Philips Research, Hamburg, Germany

Glycosaminoglycan CEST (gagCEST) imaging is an emerging molecular MR imaging technique to directly measure in-vivo GAG content in cartilaginous tissue. In this study, we demonstrated the utility of this method in assessments of lumbar intervertebral disc (IVD) degeneration by comparing with T1-rho, an established quantitative biomarker of IDD, and conventional morphological assessments. GagCEST correlated with T1-rho and Pfirrmann grades in lumbar IVD degeneration. GagCEST can provide a quantitative measure to assess degeneration of IVDs.

11:48 0318.   Spatial maps of DCEMRI enhancement in endplates of degenerating intervertebral discs reveal major pathologic changes
Volkan Emre Arpinar1, Ali Ersoz2, and L Tugan Muftuler1,3
1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2Department of Boiphysics, Medical College of Wisconsin, Wisconsin, United States, 3Center for Imaging Research, Medical College of Wisconsin, Wisconsin, United States

Nutrient transport to the discs through the endplate region was studied using Dynamic Contrast Enhanced MRI. Data were acquired from subjects with varying degrees of disc degeneration. Spatial maps of contrast enhancement were generated for each endplate and subchondral bone region in the lumbar area. A template for vertebral body – disc surface interface was generated and enhancement maps were registered to this template for analysis across all subjects and all lumbar levels. Average enhancement maps were calculated for healthy, moderately degenerated and highly degenerated discs and the results revealed major pathologic changes in the endplate regions as the discs degenerate.