ISMRM 23rd Annual Meeting & Exhibition 30 May - 05 June 2015 Toronto, Ontario, Canada

Combined Educational & Scientific Session

Cartilage-Imaging Techniques

SKILL LEVEL: Intermediate

ORGANIZERS: Eric Y. Chang, M.D., Garry E. Gold, M.D., Richard Kijowski, M.D., William B. Morrison, M.D., Ravinder R. Regatte, Ph.D. & Siegfried Trattnig, M.D.

Wednesday 3 June 2015

Overview
This hybrid course will provide an in-depth discussion of advanced functional imaging of musculoskeletal systems for evaluating joint mechanics, structure and composition. The lectures will discuss the technical aspects and the clinical and research applications of emerging MR methods, joint mechanics and function. The didactic lectures will be followed by presentation of scientific abstracts discussing novel MR methods for evaluating joint mechanics, structure and composition. This course is intended to bridge the gap between basic science research and clinical translation.

Target Audience
Radiologists and physicists who perform clinical imaging and/or research using advanced techniques.

Educational Objectives
Upon completion of this course, participants should be able to:
Recognize the emerging rapid quantitative imaging techniques for assessment of cartilage morphology and biochemistry; and
Recognize the added value of advanced functional imaging for potential clinical applications.

PROGRAM
Moderators: Richard Kijowski, M.D., Ravinder Reddy, Ph.D.
10:00   Advanced Quantitative Imaging Techniques
Feliks Kogan, Ph.D.
10:30   Clinical Applications
Siegfried Trattnig, M.D.
11:00 0578.   T2 texture change to articular cartilage over 6 months is associated with change to knee health and cartilage thickness over 2 years following ACL injury and reconstruction - permission withheld
Ashley A Williams1, Carl S Winalski2, and Constance R Chu1
1Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 2Imaging Institute and Department Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States

Patients who suffer ACL tear and reconstruction are at heightened risk of developing osteaoarthritis. Indications of future degeneration, including matrix alterations characteristic of osteoarthritis, may be present in cartilage shortly after ligament reconstruction. Quantitative assessments of T2 maps of 19 ACL-injured subjects over 2 years indicate that changes to T2 texture, but not T2 mean, observed over the first 6 months following ACL reconstruction are associated with 2-year change to cartilage thickness and morphologic joint status. Textural and mean T2 differences between ACL-reconstructed and control subjects observed at the time of ligament reconstruction resolved over the following 2 years.

11:12 0579.   
Quantitative ADC Mapping using DESS with Decreased T1 and Noise Sensitivity
Bragi Sveinsson1, Catherine Moran1, Daehyun Yoon1, Garry Gold1, and Brian Hargreaves1
1Radiology, Stanford University, Stanford, CA, United States

Early disease detection of osteoarthritis is important for treatment development and much research has recently been devoted to developing imaging methods to that end. The Double Echo Steady State (DESS) sequence has been shown to be able to provide measurements of T2 and ADC in articular cartilage, which can be used as biomarkers for disease detection, in addition to morphological information. In this work, we demonstrate the ability to use the two later echoes of two DESS scans for diffusion contrast, and how the variability of the ADC estimate will depend on spoiler strength.

11:24 0580.   Gray level co-occurrence matrix approach for T2 analysis of cartilage in knee osteoarthritis
Arttu Peuna1, Joonas Hekkala2, Marianne Haapea3, Jana Podlipska1,2, Miika T Nieminen1,3, Simo Saarakkala2,3, and Eveliina Lammentausta1,3
1Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 2Department of Medical Technology, University of Oulu, Oulu, Finland, 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Gray level co-occurrence matrix texture analysis is an effective way to analyze relaxation time maps. Parameters such as entropy and contrast can be used to depict the spatial structure of data. In this study, texture parameters were calculated from T2 maps of asymptomatic and osteoarthritic subjects using a rotating reference orientation, based on the natural curvature of the articular surface. Texture analysis showed significant differences between groups even when compartmental mean T2 values were unable to differentiate the groups. GLCM analysis of T2 maps can provide complementary information on early cartilage changes in knee OA.

11:36 0581.   
Analysis of the Relationship Between 3D Knee Bone Shape and the Progression of T1ρ and T2 6 month and 1 year after ACL Reconstruction
Valentina Pedoia1, Favian Su1, Drew Lansdown1, Richard Souza1, Benjamin Ma1, and Xiaojuan Li1
1UCSF, San Francisco, California, United States

T1lower case Greek rho /T2 MRI quantification can be used to detect cartilage early degeneration after ACL injury and reconstruction. Recently, bone shape features have been proposed as biomarkers for predicting OA progression. However, the potential role the shape in the development of post-traumatic OA is unknown. In the present study, Statistical Shape Modeling is applied to explore the relationship between knee bone shape and the progression of cartilage T1lower case Greek rho/T2 1 year after ACL reconstruction. The results of this study suggest that specific aspects of the bone shape may predict the progression of T1lower case Greek rho/T2 6 month and 1 year after ACL reconstruction.

11:48 0582.   Evaluation of Meniscal Pathology Using Quantitative Magnetic Resonance Imaging
Eric Y Chang1,2, Reni Biswas2, Betty Tran2, Sheronda Statum2, Jiang Du2, Won C Bae2, and Christine B Chung1,2
1Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 2Department of Radiology, University of California, San Diego Medical Center, San Diego, CA, United States

21 meniscal slices were evaluated using a surgical reference standard and a panel of quantitative MRI measures. We found that T2* values obtained with UTE sequences can delineate normal from degenerated menisci, thus complimenting conventional sequences. Torn menisci demonstrate higher T2, UTE-T2*, T1rho, and UTE-T1rho values compared with normal menisci.

12:00   Adjournment & Meet the Teachers