ISMRM 23rd Annual Meeting & Exhibition 30 May - 05 June 2015 Toronto, Ontario, Canada

Perfusion Imaging in the Brain & Body
SKILL LEVEL: Basic to Intermediate
ORGANIZERS: David Buckley, Ph.D., Linda Knutsson, Ph.D., & Steven Sourbron, Ph.D.
Saturday, 30 May 2015
This half-day, intermediate course is designed for scientists and clinicians who want to learn about MR imaging of perfusion and related parameters. The course will begin with a description of the physiology of perfusion, followed by the theory and methodology of the main classes of perfusion imaging techniques (dynamic susceptibility contrast MRI, dynamic contrast enhanced MRI, and arterial spin labeling). The complementary nature of techniques will be emphasized. Finally, an overview of applications of perfusion imaging in both the brain and the body will be presented, with particular attention to which methods are most appropriate for particular applications.
This course is designed for basic research scientists, medical physicists and clinicians. It is expected to provide attendees with an understanding of fundamental as well as practical aspects of perfusion MRI, and a solid background upon which to base decisions about choice of perfusion imaging methods for their own applications.

Upon completion of this course, participants should be able to:

  • Define and understand the relationships between perfusion and related parameters such as transit times, blood volume, capillary permeability, and interstitial volume;
  • Describe the basic principles of arterial spin labeling, dynamic susceptibility contrast, and dynamic contrast enhancement;
  • Assess which parameters each of the above methods are inherently sensitive to and why;
  • Describe the key issues in the extraction of physiological parameters from ASL, DSC, and DCE data;
  • Identify applications for which each of the above methods are well suited; and
  • Recognize similarities and differences between the three perfusion MRI techniques.


Moderators: Susan T. Francis, Ph.D. & Steven Sourbron, Ph.D.

08:00 What is Perfusion & How is it Measured?
Bradley J. Macintosh, Ph.D.
08:40 Perfusion Measured by MRI Using Intravascular Tracers
Ronnie Wirestam, Ph.D.
09:20 Perfusion Measured by MRI Using Extravasating Tracers
Michael S. Ingrisch, Ph.D.
10:00   Break & Meet the Teachers  
10:20 Perfusion Measured by MRI Using Diffusible Tracers - permission withheld
Susan T. Francis, Ph.D.
11:00 Applications of Perfusion MRI in the Brain  - permission withheld
Greg Zaharchuk, M.D., Ph.D.
11:40 Applications of Perfusion MRI in the Body - permission withheld
Michael Notohamiprodjo, M.D.
12:20   Adjournment & Meet the Teachers