ISMRM 23rd Annual Meeting & Exhibition 30 May - 05 June 2015 Toronto, Ontario, Canada

Quantitative Physiology
SKILL LEVEL: Intermediate
ORGANIZERS: Jonathan R. Polimeni, Ph.D. & Eric C. Wong, M.D., Ph.D.
Saturday, 30 May 2015
This course will review the current understanding of neurovascular coupling, and will survey and compare techniques that can inform measurements of both neuronal function and vascular physiology. These new methods lie at the intersection of functional, perfusion, diffusion and flow MRI, and provide complementary information about brain neurovascular physiology.
Clinicians and basic scientists using fMRI techniques to map brain activity or vascular physiology; medical physicists and engineers developing methods for functional MRI, perfusion imaging, or quantitative MRI with a focus on the underlying physiological mechanisms.

Upon completion of this course, participants should be able to:

  • Convey the current notions of neurovascular coupling and the relationship between BOLD and neuronal activity;
  • Differentiate between methods for imaging intravascular and extravascular oxygenation in brain tissue;
  • Apply combined perfusion and diffusion MRI to water permeability quantification;
  • Describe and interpret the imaging modalities for 4D flow imaging; and
  • Develop diffusion-weighted fMRI protocols and interpret the resulting BOLD responses.


Moderators: Richard B. Buxton, Ph.D. & Arno Villringer, M.D.

14:00 From Neurons to BOLD
Anna Devor, Ph.D.
14:30 From BOLD to Neurons
Richard B. Buxton, Ph.D.
15:00 Neurometabolic & Neurovascular Couplings Underlying Quantitative BOLD - permission withheld
Fahmeed Hyder, Ph.D.
15:30   Break & Meet the Teachers  
15:50 Imaging Oxygenation
Divya S. Bolar, M.D., Ph.D.
16:20 Vascular Permeability Imaging & Quantitative ASL
Danny J. J. Wang, Ph.D.
16:50 4D Flow Imaging of Vascular & CSF Dynamics
Michael Markl, Ph.D.
17:20 Diffusion-Weighted Functional MRI
Alan W. Song, Ph.D.
17:50   Adjournment & Meet the Teachers