ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Vessel Wall Imaging

Wednesday 3 June 2015

Room 716 A/B

10:00 - 12:00


René M. Botnar, Ph.D., T.B.A.

10:00 0552.   High resolution three dimensional imaging of extracranial and intracranial arteries
Lei Zhang1, Yongjun Tao2, Xiaoqing Hu1, Jun Wu2, Xin Liu1, and Yiu-Cho Chung1
1Paul C. Lauterbur Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academic of Sciences, Shenzhen, Guangdong, China, 2Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

This study proposes the use of a neurovascular coil with an appropriately optimized T1w-SPACE for vessel wall imaging of intracranial and extracranial arteries in one scan. The sequence combined good blood suppression (through DANTE) and improved T1 contrast (through a flip-down pulse) to improve image quality. An optimized refocusing pulses¡¯ flip angle series for T1w-SPACE and a good neurovascular coil increased the SNR needed for high spatial resolution. The method covers a volume of 212mm x 159mm x 40mm with an isotropic spatial resolution of 0.6mm in 7.5min. The patient study showed that the method would be clinically relevant.

10:12 0553.   Ultrahigh-resolution MRI Imaging of Intracranial atherosclerosis at 17.6 Tesla: an ex vivo Study with Histological Comparison
Shuqian Zhang1, Kazuyuki Yahagi2, li liu1, Jiadi Xu3, Frank D Kolodgie2, Renu Virmani2, Babara Crain4, Bruce A Wasserman1, and Ye Qiao1
1Radiolgoy, Johns Hopkins, Baltimore, MD, United States, 2CVPath Institute, Inc., Gaithersburg, MD, United States, 3Kennedy Krieger Institute, MD, United States, 4Pathology, Johns Hopkins, Baltimore, MD, United States

Characterization of intracranial atherosclerotic plaques using ultrahigh-resolution MRI ex vivo

10:24 0554.   
Intraplaque Hemorrhage Detection and Threshold Selection for Simultaneous Noncontrast Angiography and IntraPlaque Hemorrhage (SNAP) Images
Jin Liu1, Marina S. Ferguson1, Jinnan Wang2, Daniel S. Hippe1, Niranjan Balu1, William S. Kerwin1, Thomas S. Hatsukami1, and Chun Yuan1
1University of Washington, Seattle, WA, United States, 2Philips Research North America, NY, United States

Intraplaque hemorrhage (IPH), an important destabilizing factor in atherosclerosis progression, can be identified as hyperintensity region in Simultaneous Noncontrast Angiography and intraPlaque hemorrhage (SNAP) images. In this study, validation of SNAP in detecting IPH with histology was performed, demonstrating that SNAP can identify carotid IPH accurately in vivo. Furthermore, a threshold of 740 based on the original intensity of SNAP images were obtained by optimization, in order to detect carotid IPH automatically.

10:36 0555.   Motion-robust 3D Black-blood Carotid Wall Imaging Using Flow-sensitive Dephasing Preparation and Stack-of-Stars Trajectory
Xiaoming Bi1, Yutaka Natsuaki1, Zhaoyang Fan2, Peter Speier3, Debiao Li2, and Gerhard Laub1
1Siemens Healthcare, Los Angeles, CA, United States, 2Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Siemens Healthcare, Erlangen, Germany

High-resolution, volumetric carotid vessel wall imaging is a promising method for the rapid assessment of plaque burden. Such an imaging procedure, however, is frequently challenged by complex motions in the carotids, including pulsation of carotid arteries, swallowing, breathing, and bulk motion of patient. The goal of this work is to develop a motion-robust, black-blood 3D carotid wall imaging technique using a stack-of-stars sampling scheme. The efficacy of using such a method is compared to the conventional carotid wall imaging with Cartesian sampling. Volunteer studies show improved image quality and vessel wall delineation using the proposed flow-sensitive dephasing prepared stack-of-stars sequence.

10:48 0556.   Velocity Selective RF pulse prepared Inversion Recovery (VSIR) for carotid artery vessel wall imaging
Yunduo Li1, Shuo Chen1, Zechen Zhou1, Rui Li1, and Chun Yuan1,2
1Center for Biomedical Imaging Research, Beijing, Beijing, China, 2Department of Radiology, University of Washington, Seattle, Washington, United States

In this study, we presented a Velocity Selective RF pulse prepared Inversion Recovery (VSIR) technique for carotid artery vessel wall imaging. Simulation results demonstrate the feasibility of VS inversion pulse. In-vivo experiments showed that VSIR can be used for carotid vessel wall imaging. VSIR technique provides better SNR of vessel wall and CNR between lumen and vessel wall than iMSDE. However, in some cases that flow is not exactly along the velocity encoding direction, such as BIFU and ICA, VS sacrifices blood suppression efficiency. More applications on other vascular bed such as femoral artery will be evaluated in further study.

11:00 0557.   
Time-efficient whole-heart coronary plaque characterization with simultaneously acquired MRA
Yibin Xie1,2, Young Jin Kim3, Jianing Pang1, Jung-Sun Kim4, Qi Yang1, Zhaoyang Fan1, Hyuk-Jae Chang4, and Debiao Li1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States, 2University of California, Los Angeles, Los Angeles, California, United States, 3Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, 4Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea

Recently T1-weighted MRI with or without contrast enhancement has been used for characterizing coronary plaques showing promising prognostic value for coronary events. However the drawbacks of current protocols using conventional Cartesian acquisition and respiratory gating may hinder the clinical application of this technique due to limited anatomical coverage, low anisotropic resolution and the requirement of a separate bright-blood MRA scan. We developed a time-efficient protocol based on 3DPR with simultaneously acquired MRA to address these limitations and performed preliminary clinical validation on 11 CAD patients using CT angio, X-ray angio, and intracoronary OCT as reference.

11:12 0558.   3D-black-blood 3T-MRI for the diagnosis of thoracic large vessel vasculitis: a feasibility study - permission withheld
Karla Maria Treitl1, Stefan Maurus1, Hendrik Kooijmann-Kurfuerst2, Eva Coppenrath1, Nora N. Kammer1, Marcus Treitl1, Maximilian Reiser1, and Tobias Saam1
1Institute for clinical radiology, LMU Munich, Munich, Bavaria, Germany, 2Philips Healthcare, Philips GmbH, Hamburg, Hamburg, Germany

FDG-PET/CT is the gold standard for the diagnosis and the monitoring of large vessel vasculitis, but it causes repetitive radiation exposure. The presented, novel, isotropic-high-resolution three-dimensional T1w TSE sequence (VISTA Volumetric ISotropic TSE Acquisition) was evaluated in 23 patients with suspected large vessel vasculitis and 25 controls. The study showed that the navigated 3D black-blood MRI technique with peripheral pulse unit triggering is able to diagnose large vessel vasculitis of the thoracic vessels in 10-12 minutes scan time. Future studies are necessary to evaluate VISTA-MRI for monitoring of anti-inflammatory therapies and to perform a comparison with PET/CT and ultrasound.

11:24 0559.   Simultaneous acquisition of spatially-registered gray- and black-blood images of peripheral arteries with 3D double-echo steady-state (DESS) at 3T
Michael C Langham1, Benoit Desjardins1, Erin K Englund1, Emile R Mohler2, Thomas F Floyd3, and Felix W Wehrli1
1Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3Anesthesiology, Stony Brook University Medical Center, Stony Brook, New York, United States

We describe a new application of 3D double-echo steady-state (DESS), allowing simultaneous acquisition of spatially-registered gray and black blood images, which have the potential to address several limitations of MR angiography. 3D DESS was used to acquire gray and black blood images of the femoropopliteal and infra-popliteal arteries in healthy volunteers and patients with peripheral artery (PAD). It is shown that high-resolution dual-contrast structural 3D DESS is able to provide detailed information on vessel wall thickening, luminal geometry and calcification. Pairing 3D DESS with non-contrast MRA has the potential to improve diagnosis of PAD.

11:36 0560.   
Self-gated dynamic contrast enhanced (DCE) MRI with compressed sensing acceleration to quantify permeability in the aortic root of atherosclerotic mice
Claudia Calcagno1, Chiara Giannarelli2, Abdallah G Motaal3, Matthias Nahrendorf4, Willem JM Mulder5,6, Zahi A Fayad1, and Gustav J Strijkers3
1Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands, Netherlands, 4Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States, 5Icahn School of Medicine at Mount Sinai, New York, NY, United States, 6Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands, Netherlands

Enhanced endothelial permeability is a hallmark of atherosclerotic plaques at high risk for causing severe clinical events. Here we present a method to quantify plaque permeability in the aortic root of ApoE -/- mice, using self-gated DCE-MRI with compressed sensing acceleration.

11:48 0561.   Large coverage HOmologous Black-Bright blood Interleaved imaging sequence (LaHOBBI) for 3D dynamic contrast enhanced MRI of vessel wall
Haikun Qi1, Shuo Chen1, Zechen Zhou1, Jinnan Wang2, Peter Koken3, Niranjan Balu4, and Huijun Chen1
1Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, Beijing, China, 2Philips Research North America, Briarcliff Manor, New York, United States, 3Innovative Technologies, Research Laboratories, Philips Technologies GmbH, Hamburg, Germany, 4Radiology, University of Washington, Seattle, WA, United States

Dynamic contrast enhanced (DCE) MRI is important in quantifying inflammatory features of atherosclerotic plaque, and interleaved black-bright imaging technique is essential for quantitative vessel wall DCE analysis. In this study, a Large coverage HOmologous black-bright blood Interleaved imaging sequence (LaHOBBI) for vessel wall DCE MRI was proposed. The feasibility of the conducting the proposed sequence was demonstrated by in vivo experiment on carotid. The LaHOBBI sequence enables 3D large coverage, high spatial resolution vessel wall DCE imaging and 2D high temporal bright blood imaging for accurate AIF extraction, which ensures the quantitative DCE analysis and coverage of atherosclerotic plaque.