ISMRM 23rd Annual Meeting & Exhibition • 30 May - 05 June 2015 • Toronto, Ontario, Canada

Scientific Session • Spinal Cord & ENT Imaging
 

Wednesday 3 June 2015

Room 701 A

16:00 - 18:00

Moderators:

Roland R. Lee, M.D., Yukio Miki, M.D., Ph.D.

16:00 0681.   
Regional and age-related variations of the healthy spinal cord structure assessed by multimodal MRI (diffusion, inhomogeneous magnetization transfer, ihMT)
Manuel Taso1,2, Olivier M. Girard3,4, Guillaume Duhamel3,4, Arnaud Le Troter3,4, Guilherme Ribeiro3,4, Thorsten Feiweier5, Maxime Guye3,4, Jean-Philippe Ranjeva3,4, and Virginie Callot3,4
1CRMBM-CEMEREM UMR 7339, Aix-Marseille Université, CNRS, Marseille, France, 2LBA UMR T 24, Aix-Marseille Université, IFSTTAR, Marseille, France,3CRMBM UMR 7339, Aix-Marseille Université, CNRS, Marseille, France, 4CEMEREM, Pole d'imagerie médicale, Hopital la TImone, AP-HM, Marseille, France,5Siemens AG, Healthcare, Erlangen, Germany
 
MRI can provide valuable information about spinal cord (SC) structure. In the current study, we combine multimodal MRI (DTI and inhomogeneous magnetization transfer, ihMT) and atlas-based analysis of the derived parametric data to study: 1) healthy internal SC structural variations (in terms of myelin and axonal content at different levels) and 2) impairment occurring through the lifespan. Thereby, we highlighted vertebral level and sensory/motor tract-specific SC structure dependency, as well as demyelination and axonal loss occurring with age. Altogether, this study also provides a normative DTI and MT/ihMT database metrics at different ages, useful for pathological studies (MS, ALS).

16:12 0682.   
Validation of MRI microstructure measurements with Coherent Anti-Stokes Raman Scattering (CARS)
Tanguy Duval1, Alicja Gasecka2,3, Philippe Pouliot1,4, Daniel Côté2,3, Nikola Stikov1,5, and Julien Cohen-Adad1,6
1Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, Qc, Canada, 2Quebec Mental Health University Institute, Québec, Qc, Canada,3Doptic, photonic and laser Center, Université Laval, Québec, Qc, Canada, 4Montreal Heart Institute, Montreal, Quebec, Canada, 5Montreal Neuronal Institute, McGill University, Montréal, Québec, Canada, 6Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montréal, Qc, Canada

Histology is considered to be the gold standard for validating quantitative MRI techniques. However, common histology techniques can induce biases due to the tissue preparation (fixation, cutting and staining), rendering challenging the validation of quantitative MRI biomarkers. Recently, a large-scale microscopy technique called Coherent Anti-Stokes Raman Scattering (CARS) was introduced, enabling (i) sub-micrometer resolution, (ii) in-depth focus preventing artifacts related to non-perfectly flat tissue surface and (iii) specific contrast to myelin without the need for staining. Here we applied the CARS technique to validate AxCaliber experiments for estimating axon diameter measurements.

16:24 0683.   
Diffusion MRI reveals tissue specific changes in early and late stages of degeneration within the spinal cord
Torben Schneider1, Gemma Nejati-Gilani2,3, Mohamed Tachrount4, Ying Li5, Amber Hill4, Olga Ciccarelli4, Ken Smith6, David Thomas7, Daniel C Alexander3, and Claudia A M Wheeler-Kingshott1
1NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom, 3Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 4Brain Repair & Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 5Spinal Repair Unit, Brain Repair & Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 6Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 7Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, London, United Kingdom

Diffusion MRI has been applied successfully before to study rodent models of spinal cord damage, but no attempt has been made to try to explicitly model the different pathological effects in the damaged white matter. This study demonstrates the application of a complex diffusion MRI model to early and late axonal injury. We find that axon radius, together with changes in diffusivity and compartmentalisation are discriminating best between early and late stage changes in spinal cord lesion and replicate independent measures of axonal damage in histology.

16:36 0684.   
Longitudinal characterization of the Wallerian degeneration process by a multi-compartment diffusion model: DIAMOND after a rhizotomy in the rat spinal cord and comparison with the histology
Damien Jacobs1, Benoit Scherrer2, Aleksandar Jankovski3, Anne des Rieux4, Maxime Taquet1, Bernard Gallez4, Simon K. Warfield2, and Benoit Macq1
1ICTEAM, Universite catholique de Louvain, Louvain-La-Neuve, Belgium, 2Computational Radiology Laboratory, Boston Childrens Hospital, Massachusetts, United States, 3Hopital universitaire Mont-Godinne, Universite catholique de Louvain, Godinne, Belgium, 4LDRI, Universite catholique de Louvain, Brussels, Belgium

The aim of this study is to investigate the Wallerian degeneration process by DIAMOND, a multi-compartment diffusion model, in the rat spinal cord after a rhizotomy. With a longitudinal imaging approach and several histological observations for each specific cellular response, the fluctuations of the diffusion parameters are analyzed and compared to the Wallerian degeneration process in the course of time.

16:48 0685.   Diffusion Basis Spectrum Imaging quantifies pathologies in Cervical Spondylotic Myelopathy
Peng Sun1, Rory Murphy2, Yong Wang1, Joanne Wagner3, Sammir Sullivan1, Paul Gamble2, Kim Griffin1,2, Wilson Z. Ray2, and Sheng-Kwei Song1
1Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Neurosurgery, Washington University in St. Louis, St. Louis, MO, United States, 3Physical Therapy and Athletic Training, Saint Louis University, St. Louis, MO, United States

Cervical spondylotic myelopathy (CSM) is the most common form of spinal cord injury, but no effective diagnostic approach available to accurately reflect underlying tissue damage. In this study, newly developed diffusion basis spectrum imaging (DBSI) was applied to quantify pathologies in CSM. DBSI successfully delineated axon and myelin injury, quantified the extent of axon loss and edema of CSM spinal cord. Findings suggest that axon loss may be the primary contributor to neurological impairment in CSM. The multiple metrics derived by DBSI, could offer an insight to the underlying pathologies responsible for the evolving neurological impairments in CSM.

17:00 0686.   
Evaluating the Feasibility of Monitoring In Vivo Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging
Ilwoo Park1, Jason F. Talbott1,2, and Sarah J. Nelson1,3
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Brain and Spine Injury Center (BASIC), San Francisco General Hospital, San Francisco, CA, United States, 3Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, CA, United States

This study has demonstrated the feasibility of using hyperpolarized 13C MR imaging with [1-13C]pyruvate for evaluating in vivo metabolism of spinal cord. High pyruvate and relatively small lactate signal were observed in the cervical spinal cord of uninjured rats. The results from this study suggest that this technique may provide a unique non-invasive imaging tool that is able to monitor biochemical processes underlying spinal cord injury.

17:12 0687.   Computer-aided diagnosis of head and neck lesions from non-Gaussian diffusion MRI signal patterns - permission withheld
Mami Iima1, Akira Yamamoto1, Denis Le Bihan2,3, Shigeru Hirano4, Ichiro Tateya4, Morimasa Kitamura4, and Kaori Togashi1
1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, 2Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, 3Neurospin, CEA-Saclay Center, Gif-sur-Yvette Cedex, France, 4Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

This prospective study included 46 patients suspected of head and neck tumors. They were scanned using a RS-EPI diffusion MRI sequence implemented on a 3T MRI scanner. Images were analyzed with a new approach algorithm which enables automatic classification of tumor types from a "signature index" (S-index) directly based on the non-Gaussian diffusion signal pattern obtained from 2 gkey b valuesh. This computer-assisted diagnostic algorithm allowed malignant and benign lesions to be differentiated with a high AUC (0.89). The lesion S-index histogram and 3D display also highlighted the importance of tumor heterogeneity.

17:24 0688.   Diffusion Imaging Of Head And Neck At High Angular And Spatial Resolution Using Multi-Shot Spirals
Merry Mani1, Mathews Jacob2, and Vincent Magnotta3
1Dept of Psychiatry, University of Iowa, Iowa City, IA, United States, 2Dept of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States, 3Dept of Radiology, University of Iowa, Iowa City, IA, United States

Brain regions such as pons, cerebellum, spine etc are difficult to image using diffusion imaging due to the presence of air/bone/tissue interfaces causing severe susceptibility artifacts. In addition, cardiac pulsation, respiratory and swallowing motions also adversely affect these regions. We present a high spatial and angular resolution diffusion scheme that can image these regions without being severely corrupted by these artifacts. The proposed method uses a compressed sensing based joint k-q space under-sampling using multi-shot variable density spirals to image these regions. The motion-compensated joint reconstruction can recover diffusion orientation distribution functions at high resolution to enable the study of these regions.

17:36 0689.   
High spatio-temporal resolution multi-slice real time MRI of speech using golden angle spiral imaging with constrained reconstruction, parallel imaging, and a novel upper airway coil
Sajan Goud Lingala1, Yinghua Zhu1, Yoon-Chul Kim2, Asterios Toutios1, Shrikanth Narayanan1, and Krishna S Nayak1
1Electrical Engineering, University of Southern California, Los Angeles, California, United States, 2Samsung Medical Center, Seoul, Korea

Real time MRI (RT-MRI) is a powerful tool to visualize the complex spatio-temporal coordination of upper airway structures during speech production. In this work, we propose to improve imaging trade-offs in RT-MRI by utilizing (a) a novel upper airway coil which has improved sensitivity in upper airway regions of interest, (b) a flexible slice selective spiral acquisition with golden angle time interleaving, and (c) a temporal constrained reconstruction scheme. With the proposed approach, we show improved depiction of fine articulatory movements (such as production of consonant clusters) by enabling time resolution of 12 msec for single slice imaging, and 36 msec for concurrent three slice imaging.

17:48 0690.   High resolution magnetic resonance elastography of the human eye in vivo: a feasibility study
Jürgen Braun1, Sebastian Hirsch2, Jing Guo2, Katharina Erb-Eigner2, and Ingolf Sack2
1Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Berlin, Germany, 2Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

The feasibility of in vivo MR-elastography (MRE) of human eyes is demonstrated. A clinically applicable actuator for inducing shear waves into the eye was constructed which could be combined with a standard head coil and a specialized eye coil. 3D MRE of 90 and 100 Hz vibration frequency and 1mm^3 cubic voxel resolution was used for reconstructing viscoelastic parameter maps of magnitude and phase angle of the complex shear modulus. We measured a magnitude modulus of 1084 plus-or-minus sign 366 Pa in the vitreous body which agrees to in-vivo values obtained in the mouse.