ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Combined Educational & Scientific Session: Ultrastructural & Functional Bone & Muscle Imaging

Skill Level: Intermediate to Advanced

Organizers: Jenny T. Bencardino, M.D., Eric Y. Chang, M.D., Christine Chung, M.D., Ravinder R. Regatte, Ph.D., Philip Robinson, M.D. & Siegfried Trattnig, M.D.

Monday 09 May 2016

This session will address issues related to bone structure and muscle physiology as well as their interfaces. Lecturers will discuss basic physics and clinical applications.

Target Audience
This course is directed to clinicians, researchers  interested in applying emerging MR imaging techniques to musculoskeletal imaging as well as researchers seeking to enhance their knowledge of the clinical applications and impact of these techniques.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Review the biochemical composition and structure of bone;
  • Identify the role of bone quality imaging techniques for assessment of bone microarchitecture and mechanics; and
  • Implement and evaluate muscle physiology and biomechanics using advanced imaging techniques.

Moderators: Mark Does, Jiang Du
Muscle Quality and Function
John Thornton1
1MRC Centre for Neuromuscular Diseases, University College London, London, United Kingdom
Target audience: This presentation is intended to inform those interested in the application of quantitative MRI to probe structure, function or pathology in skeletal muscle.    Objectives: To outline the properties of skeletal muscle pertinent to quantitative MRI, the various MRI-accessible quantities that reflect muscle quality, and how MRI measurements correlate with disease severity and functional assessment

Clinical Applications - Permission Withheld
Thomas M Link1
1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States
Over the past decade advanced quantitative MRI techniques have evolved which allow to characterize bone and muscle structure and function. Clinically applicable techniques analyzing bone quality and strength are high resolution, morphological MRI, UTE and MRS. These techniques have shown promise in clinical studies, providing information beyond bone mineral density, the current standard measurement. Novel technologies focusing on the assessment of muscle structure and function are chemical shift-based fat quantification techniques, MRS, T2 relaxation time measurements and BOLD MRI, all of which are also clinically applicable and were used in investigating pain syndromes and disorders of muscle function.   

Bound- and Pore-Water MRI of Cortical Bone in Osteoporotic Patients
Mary Kate Manhard1, S Bobo Tanner2, Daniel F Gochberg3, Jeffry S Nyman4, and Mark D Does1
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Department of Medicine, Vanderbilt University, Nashville, TN, United States, 3Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 4Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States
Osteoporotic fractures are a growing problem, and X-ray based methods do not always identify individuals at risk of a fracture. MRI based methods of bound and pore water in cortical bone have the potential to offer new information about fracture resistance. These methods were implemented on both osteoporotic volunteers and healthy controls in the tibia. Osteoporotic subjects had significant decreases in bound water concentration and slight increases in pore water concentration compared to healthy subjects. These promising results will allow for further investigation of changes of bound and pore water concentrations across diseases and with response to various treatment methods. 

Magnetic resonance elastography characterization of skeletal muscle stiffness changes resulting from pressure ulcers
Jules Laurent Nelissen1,2, Willeke Traa3, Larry de Graaf1, Kevin Moerman4, Cees Oomens3, Aart Nederveen5, Ralph Sinkus6, Klaas Nicolay1, and Gustav Strijkers2
1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands, 3Biomechanics of Soft Tissues, Eindhoven University of Technology, Eindhoven, Netherlands, 4MIT media lab, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Radiology, Academic Medical Center, Amsterdam, Netherlands, 6Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom
We have investigated the feasibility of using Magnetic Resonance Elastography (MRE) to quantify muscle-tissue mechanical properties and changes therein related to the development of deep tissue injury type of pressure ulcers. MRE measurements were performed before and after damage-inducing indentation of the tibialis-anterior muscle of Sprague Dawley rats. Current study demonstrates that changes in muscle-tissue mechanical properties associated with deep tissue injury can be quantified by MRE. We expect that better knowledge of changes in soft tissue mechanical properties due to damage, measured with MRE, will provide new insights in the aetiology of deep tissue injury and other muscle pathologies.

Selective in Vivo Bone Imaging with Long-T2 suppressed PETRA MRI
Cheng Li1, Jeremy F. Magland1, Xia Zhao1, Alan C. Seifert2, and Felix W. Wehrli1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
An IR-based long-T2 suppressed PETRA sequence was designed and optimized to image sub-millisecond-T2 tissue components, e.g. collagen-bound bone water. To minimize scan time signal was sampled repeatedly after each inversion with individual excitation flip-angle designed to yield constant short-T2 signal amplitude. A fast non-iterative reconstruction algorithm combined with phase-modulated excitation pulse was applied to minimize image artifacts due to non-uniform excitation profile, allowing for increased flip-angle and higher SNR. Optimized long-T2 suppressed PETRA allows imaging of bone matrix water, opening up new possibilities for anatomic bone imaging at isotropic resolution and quantification in clinically practical scan times.

In vivo skeletal muscle fiber length measurements using a novel MRI diffusion tensor imaging approach: reproducibility and sensitivity to passive stretch. - Permission Withheld
Jos Oudeman1, Valentina Mazzoli1,2,3, Marco A Marra2, Klaas Nicolay3, Mario Maas1, Nico Verdonschot2, Andre M Sprengers2, Aart J Nederveen1, Gustav J Strijkers4, and Martijn Froeling5
1Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Orthopedic Research Lab, Radboud UMC, Nijmegen, Netherlands, 3Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands,4Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 5Radiology, University Medical Center, Utrecht, Utrecht, Netherlands
Diffusion Tensor Imaging in combination with tractography facilitates 3D visualizations of the muscle architecture, which is described by fiber length and pennation angle. In order to get accurate fiber length estimation, tendinous structures need to be separated from muscles. In this work we propose a new method for semiautomatic tendon segmentation. The fiber length obtained after tendon segmentation is seen to be reproducible. Furthermore the sensitivity of the method allows for detection of change in fiber length whit muscle stretch. The observed behavior is in agreement with the known antagonistic function of muscles.

31P-MRS and MRI of lower leg muscle oxidative metabolism in heart failure patients
Ding Xia1, Stuart D. Katz2, and Ravinder R. Regatte1
1Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, United States, 2Division of Cardiology, Department of Medicine, New York University Langone Medical Center, New York, NY, United States
We measured the lower leg muscle oxidative metabolism in healthy volunteers (n=5) and heart failure patients (n=6) with quantitative 31P-MRS and MRI at 3T clinical scanner. The post-exercise rate of phosphocreatine (PCr) resynthesis was decreased in heart failure subjects (i.e. delayed PCr recovery time) compared to healthy volunteers in global calf muscle, as well as in predominantly fast twitch (type II) gastrocnemius muscle (medial and lateral, GM and GL) and predominantly slow twitch (type I) soleus (SOL) muscle.

Adjournment & Meet the Teachers

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