ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Scientific Session: Structural & Functional Imaging of Muscle

Wednesday, May 11, 2016
Room 331-332
16:00 - 18:00
Moderators: Bruce Damon, S. Sendhil Velan

The relationships between microstructure and the diffusion tensor in simulated skeletal muscle
David B Berry1, Benjamin M Regner2, Vitaly L Galinsky3, Samuel R Ward1,4,5, and Lawrence R Frank3
1Bioengineering, UCSD, La Jolla, CA, United States, 2Institute of Engineering in Medicine, UCSD, La Jolla, CA, United States, 3Center for Scientific Computation in Imaging, UCSD, La Jolla, CA, United States,4Orthopaedic Surgery, UCSD, La Jolla, CA, United States, 5Radiology, UCSD, La Jolla, CA, United States
Diffusion tensor imaging (DTI) has been used to measure changes in restricted diffusion in skeletal muscle after injury, which are thought to track microstructural, and therefore functional changes. However, there are few direct comparisons between muscle microstructure and DTI measurements because it is difficult to precisely control in vivo experiments. Here, we use a computational (in silico) modeling approach to explore changes in DTI measurements as muscle microstructure is systemically changed. Muscle fiber diameter and edema have the largest effects on the DT. Additionally, we have shown multi-echo DTI is required to resolve changes in microstructure when edema is present. 

Towards robust Diffusion Tensor Imaging of skeletal muscles via an automatic artifact removal tool.
Chiara Giraudo1, Stano Motyka1, Siegfried Trattnig1, and Wolfgang Bogner1
1Department of Biomedical Imaging and Image-guided Therapy- MR Centre of Excellence, Medical University Vienna, Vienna, Austria
STEAM-DTI sequence recently provided excellent results for DTI analysis of muscle fibers (e.g., high signal-to-noise ratio, low apparent diffusion coefficient, high fractional anisotropy values) but demonstrated also to be affected by strong artifacts, which can be assumed to be due to involuntary muscle contractions. The hereby proposed automatic post-processing method, based on weighted mean of the averages for each DTI-direction and b-value, demonstrated to successfully detect and correct these artifacts, improving fiber tracking of the calf muscles.

Super-Resolution Magnetic Resonance Elastography (SR-MRE) of Exercise Induced Muscle Damage (EIMD)
M. Perrins1, E. Barnhill2, P. Kennedy1, J. Braun2, I. Sack2, A. Hunter3, C. Brown4, E. van Beek1, and Neil Roberts1
1University of Edinburgh, Edinburgh, United Kingdom, 2Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3School of Sport, University of Stirling, Stirling, United Kingdom, 4The Mentholatum Company Ltd., East Kilbride, United Kingdom
Super-Resolution (SR) Magnetic Resonance Elastography (MRE) was applied to measure thigh muscle viscoelastic properties in 20 subjects in whom Exercise Induced Muscle Damage (EIMD) was produced using a well-established muscle damage protocol. SR-MRE is made possible by analysing Multi-frequency MRE (MMRE) in a manner such that multiple low-resolution images of the same scene are interpolated and fused to create a single, high-resolution image. Muscle tissue is well suited to study using SR-MRE and the sites of muscle damage could be clearly identified suggesting potential useful clinical applications for the technique. SR-MRE also has potential to provide insight regarding the mechanisms underlying tissue damage in EIMD.  

A Quantitative Investigation of the Fatty Degeneration of the Supraspinatus Muscle after Rotator Cuff Tear: SPLASH-MRI, Model-Based T$$$_1$$$ Mapping and Shear Wave Ultrasound
Andreas Max Weng1, Fabian Gilbert2, Johannes Tran-Gia1,3, Tobias Wech1, Detlef Klein1, Thorsten Alexander Bley1, and Herbert Köstler1
1Department of Diagnostic and Interventional Radiology, University of Würzburg, Würzburg, Germany, 2Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Würzburg, Würzburg, Germany, 3Department of Nuclear Medicine, University of Würzburg, Würzburg, Germany
Fatty degeneration of the rotator cuff is often investigated by a visual inspection of T$$$_1$$$-weighted MR images. Since this approach is in debate the aim of this study was to investigate fatty degeneration of the supraspinatus muscle by quantitative techniques: SPLASH, model-based acceleration for parameter mapping (MAP) T$$$_1$$$ measurement and shear wave ultrasound. The obtained values from SPLASH and T$$$_1$$$ mapping are in good accordance (Pearson’s r=0.82). However, shear wave ultrasound does neither correlate well with SPLASH (Spearman’s rho= 0.30) nor with MAP (rho=0.19). Since data acquisition time of the T$$$_1$$$ mapping technique used in our study is very short (4s), this might be the technique of choice for investigation of the fatty degeneration of the supraspinatus after rotator cuff tear.

Assessment of  passive muscle elongation using DTI: Correlation between fiber length and diffusion coefficients
Valentina Mazzoli1,2,3, Jos Oudeman1, Marco A Marra3, Klaas Nicolay2, Nico Verdonschot3, Andre M Sprengers3, Martijn Froeling4, Aart J Nederveen1, and Gustav J Strijkers5
1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands,3Orthopaedic Research Lab, Radboud University Medical Center, Nijmegen, Netherlands, 4Department of Radiology, University Medical Center, Utrecht, Netherlands, 5Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands
The aim of this study is to explore Diffusion Tensor Imaging in the assessment of passive muscle elongation. We investigated two dorsiflexor and two plantarflexor muscles of the lower leg with the foot in dorsiflexion, neutral and plantarflexion position. Significant negative correlation was found between changes in fiberlength caused by passive muscle lengthening and radial diffusivity for all muscles. Furthermore the rate of change in radial diffusivity was compatible with a cylindrical model with constant volume. These findings give more insight into diffusion mechanisms in skeletal muscles and are highly relevant for biomechanical models.

Age-Related Changes in Diffusion Tensor Imaging Measures in Human Skeletal Muscle
Donnie Cameron1, David A. Reiter1, Kenneth W. Fishbein1, Christopher M. Bergeron1, Richard G. Spencer1, and Luigi Ferrucci1
1National Institute on Aging, National Institutes of Health, Baltimore, MD, United States
This work investigates how ageing influences diffusion tensor imaging (DTI) measures through application of a robust protocol to the human thigh. Fifteen participants, from 27-73 years old, were recruited, and mean diffusivity (MD) and fractional anisotropy (FA) were calculated in their quadriceps and plotted against age. Fibre tractography was also calculated. Rectus femoris FA showed a significant correlation with age (R2=0.27, p=0.04), while FA approached significant correlations in other muscle heads. MD had a more complicated relationship with age, if any, in contrast to previous work where lipid influence was neglected. This highlights the need for high-quality fat-suppression in DTI.

A multimodal MR approach to evaluate complex muscle degeneration processes in Duchenne Muscular Dystrophy
Melissa Tamara Hooijmans1, Melissa Tamara Hooijmans1, Nathalie Doorenweerd1, Jedrek Burakiewicz1, Andrew Webb1, Jan Vershuuren2, Erik Niks2, and Hermien Kan1
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Neurology, Leiden University Medical Center, Leiden, Netherlands
Quantitative MRI and MRS are increasingly important as non-invasive and objective outcome measures in therapy development for DMD. Several MR indices, have been shown to correlate individually with age and functional measures. However, much less attention has been given to how these indices relate to each other. Our work combined quantitative MRI and spatially resolved 31P MRS in the lower leg muscles of DMD patients and showed that combining multimodal MR measures is very important to objectively assess muscle degeneration processes and potentially the effect of therapeutic interventions in DMD.

Multi parametric MRI evaluation of skeletal muscle growth and myopathies in mice
Kerryanne V. Winters1,2, Olivier Reynaud1,2, Dmitry S. Novikov1,2, Els Fieremans1,2, and Sungheon G. Kim1,2
1Center of Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research, NYU Langone Medical Center, New York, NY, United States
The random permeable barrier membrane (RPBM) model for diffusion tensor imaging (DTI) provides a non-invasive modality potentially useful for early and accurate diagnosis for the wide range of myopathies. We have utilized the DTI-RPBM method to assess myofiber changes in the Surface-to-Volume ratio S/V and sarcolemma permeability κ as markers in growing and wasting skeletal muscle. Preliminary results show that S/V and κ decrease in both wild-type and mdx mice, with a more pronounced change between weeks 3 and 4 in mdx mice. The conventional IDEAL-Dixon and T2 mapping measures were not sensitive enough to observe the same change.

31P-MRI using A Spectrally Selective 3D non-Cartesian FLORET Sequence at 7 T
Prodromos Parasoglou1, Ryan Brown1,2, and Guillaume Madelin1
1Department of Radiology, New York University School of Medicine, New York, NY, United States, 2NYU WIRELESS, Polytechnic Institute of New York University, Brooklyn, NY, United States
We developed a spectrally selective 3D non-Cartesian FLORET pulse sequence to map phosphorus-containing metabolites in the human tissue. In particular, through this highly efficient pulse sequence we mapped phosphocreatine and γ-adenosine triphosphate at 1.4 cm isotropic nominal voxel size in the human brain. In addition, we were able to map phosphocreatine in the skeletal muscle during exercise and recovery with 6 s temporal resolution. We showed that spectrally selective 3D-FLORET is an efficient pulse sequence that can be used to image 31P-containing metabolites in the human tissue when high spatiotemporal resolution is needed.

Association of quadriceps muscle fat with isometric strength measurements in healthy males using chemical shift encoding-based water-fat MRI
Thomas Baum1, Stephanie Inhuber2, Michael Dieckmeyer1, Christian Cordes1, Stefan Ruschke1, Elisabeth Klupp3, Holger Eggers4, Hendrik Kooijman5, Ernst J Rummeny1, Ansgar Schwirtz2, Jan S Kirschke3, and Dimitrios C Karampinos1
1Department of Radiology, TU Munich, Munich, Germany, 2Department of Sports and Health Sciences, TU Munich, Munich, Germany, 3Section of Neuroradiology, TU Munich, Munich, Germany, 4Philips Research Laboratory, Hamburg, Germany, 5Philips Healthcare, Hamburg, Germany
MR-based assessment of quadriceps muscle fat has been proposed as surrogate marker in sarcopenia, osteoarthritis, and neuromuscular disorders. The present study demonstrated strong associations between chemical shift encoding-based water-fat MRI quadriceps inter- and intramuscular fat parameters and corresponding physical strength measurements in healthy males. Thus, chemical shift encoding-based water-fat MRI can provide clinically important information beyond quadriceps muscle morphology and T1-weighted muscle fat quantifications and may potentially track early changes in muscles that are not severely atrophied or fatty infiltrated in the beginning of a disease process.

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.