ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Scientific Session: Quantitative MSK Imaging

Monday, May 9, 2016
Summit 2
16:30 - 18:30
Moderators: Delphine Perie, Yongxian Qian

Measurement and Compensation of Respiration-Induced B0 Variations for Bone Marrow Fat Quantification in Lumbar Spine - Permission Withheld
Yoonho Nam1, Joon-Yong Jung1, Hyun Seok Choi1, Eojin Hwang1, Hongpyo Lee2, and Dong-Hyun Kim2
1Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 2Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea, Republic of
Fat fraction of the bone marrow has been suggested as an important quantitative parameter in the assessment of treatment response and determination of the benignity in oncologic imaging. Therefore, accurate fat quantification is a prerequisite for the fat fraction to be established as a reliable imaging biomarker. For this purpose, spoiled gradient echo sequences have been commonly used. However, gradient echo imaging is susceptible to B0 variations from various sources such as respiration, cardiac pulsation. In this study, we investigate and compensate the effects of respiration-induced B0 variations on fat quantification of the bone marrow in the lumbar spine.

Quantitative Muscle Perfusion with DCE-MRI Shows Distinct Load-Dependent Exercise-Stimulated Muscle Perfusion Patterns
Jeff L. Zhang1, Christopher Hanrahan1, Christopher C. Conlin1, Corey Hart2, Gwenael Layec2, Kristi Carlston1, Daniel Kim1, Michelle Mueller3, and Vivian S. Lee1
1Radiology, University of Utah, Salt Lake City, UT, United States, 2Internal Medicine, University of Utah, Salt Lake City, UT, United States, 3Vascular surgery, University of Utah, Salt Lake City, UT, United States
Noninvasive mapping of calf muscle perfusion with high spatial resolution has potential for assessing the severity of peripheral artery disease (PAD) and studying associated capillary density abnormality. We tested our novel DCE-MRI method to measure calf muscle hyperemia stimulated by plantar flexion at three different workloads. Increases in exercise load caused increased total perfusion in gastrocnemius, with a heterogeneous pattern at medium load and homogeneous at higher load. Perfusion in soleus did not increase until very heavy load of 16 lbs. DCE-MRI provides high spatial resolution measurement of post-exercise muscle perfusion.  

Gender Differences in Sodium Deposition in Muscle and Skin
Ping Wang1,2, Muge Serpil Deger3, Hakmook Kang4, T. Alp Ikizler3, Jens M. Titze5, and John C. Gore1,2
1Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States, 5Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
Sodium ions play a vital role in cellular homeostasis and electrochemical activity throughout the human body.  Previous studies have measured muscle and skin sodium contents in vivo in humans using MRI and have shown characteristic changes with age and as a result of pathological changes.  In this study, we found significant gender differences in sodium deposition between muscle and skin, with male has higher sodium content in skin than in muscle, while female has higher muscle sodium than skin sodium.  This observation seems to be more reliable with the increase of age.

Correlation of Mono-exponential and Bi-exponential UTE-T2* Analyses and Biomechanics in Human Achilles Tendons
Eric Y Chang1,2, Robert M Healey3, Reni Biswas2, Sheronda Statum2, Betty Tran2, Kenyu Iwasaki4, Jiang Du2, Won C Bae2, and Christine B Chung1,2
1Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 2Department of Radiology, University of California, San Diego Medical Center, San Diego, CA, United States, 3Department of Orthopaedic Surgery, University of California, San Diego Medical Center, San Diego, CA, United States, 4Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan
In this pilot study, we sought to determine if mono-exponential T2, mono-exponential UTE-T2*, or bi-exponential UTE-T2* correlated with biomechanical properties in human Achilles tendons. We found very high and significant correlation coefficients between mono-exponential T2* (rho = 0.90, p = 0.002) and bi-exponential T2* fractions (rho = -0.97, p < 0.001) obtained using the UTE-Cones sequence and ultimate tensile strain. Ultimate tensile strain represents the percentage change in tendon length prior to failure and high strains have been previously associated with tendon degeneration. Our results suggest that non-invasive MRI of the Achilles tendon may serve as a surrogate measure.

A comparison of denoising methods in dynamic MRS
Benjamin C Rowland1 and Alexander P Lin1
1Centre for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States
 MR spectroscopy is often used to study dynamic systems, such as muscle energetics using 31P. The need to perform temporal averaging to improve signal to noise ratios can compromise the temporal resolution of the measurements. Indirect time domain denoising can help to resolve this issue. In this study we evaluate six potential denoising approaches for dynamic MRS.

Extracting Quantitative Information From MRI Bound- and Pore-Water Maps of Cortical Bone
Mary Kate Manhard1, Sasidhar Uppuganti2, Mathilde C Granke2, Daniel F Gochberg3, Jeffry S Nyman2, and Mark D Does1
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States, 3Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States
Bound and pore water concentration measures of cortical bone found from MRI have been shown to correlate with material properties of bone, but the ideal way to analyze and draw information from 3D quantitative maps remains unclear. Material properties of cadaver radii found from a 3-point bend test were correlated with characteristics of the distribution of bound and pore water concentrations (e.g. mean, skewness) in ROIs found from different segmentations. Results highlighted the importance of segmentation method as well as quantitative measures drawn from the maps.  

Detection of the meniscal blood supply changes in meniscal problems with Intravoxel incoherent motion MR imaging
Tan Guo1, Dandan Zheng2, Bing Wu2, and Min Chen1
1Radiology, Beijing Hospital, Beijing, China, People's Republic of, 2GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of
The blood supply of meniscus is an essential indicator for the prognosis of meniscal problems. With a favorable blood supply of the teared meniscus, its tend to preserve the meniscus as much as possible at partial meniscetomy and meniscal repair. Intravoxel incoherent motion (IVIM) theory provide information about microcirculation of blood in addition to the pure molecular diffusion. The perfusion information detected with IVIM is emphasized on microvascular bed, which is the typical blood supply pattern of meniscus. In this study, IVIM model were used to estimate the change of vasculature in normal, degenerated and teared meniscus.

Orientation anisotropy of quantitative rotating and laboratory frame relaxation parameters in articular cartilage
Jari Rautiainen1, Lassi Rieppo2,3, Simo Saarakkala2,3,4, and Mikko Johannes Nissi1,5
1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 5Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
Classical ($$$T_1$$$, $$$T_2$$$) and several rotating frame quantitative MR parameters have been used for evaluation of composition and structure of articular cartilage, and demonstrated to have variable sensitivity to tissue orientation. The orientation dependence of $$$T_1$$$, $$$T_2$$$, $$$T_2^*$$$, CW-$$$T_{1\rho}$$$ with four spin-lock amplitudes, adiabatic $$$T_{1\rho}$$$ with three different pulse modulations, adiabatic $$$T_{2\rho}$$$ and $$$T_{\rm RAFF}$$$ relaxation times were further investigated at 9.4T at different orientations of articular cartilage relative to B0 and compared with polarized light microscopy of the same tissue. $$$T_1$$$, adiabatic $$$T_{1\rho}$$$ with HS1-pulse and CW-$$$T_{1\rho}$$$ at 2 kHz spin-lock demonstrated the least orientation dependence.

The value of DWI with ADC mapping for assessing synovitis and bone erosion in early stage of RA
Xinwei Lei1, Jin QU1, Ying ZHAN1, Huixia Li1, and Yu Zhang2
1Tianjin First Center Hospital, Tianjin, China, People's Republic of, 2Philips Healthcare, Beijin, China, People's Republic of
The aim of study was to explore whether synovitis and bone erosion judged by ADC values correspond exactly or not to those judged by CE-MRI. 25 patients were examined by 3.0T MR including DWI and CE-MRI. ADC value of synovitis and bone erosion was signi?cantly lower than that of joint effusion and cysts. ADC values of 2.0 was found distinguishing joint effusion from synovitis, and bone erosion from cysts. Therefore, MR diffusion provides additional information to the routine MRI sequences rendering it an effective non-invasive tool in differentiating between synovitis and joint effusion, as well as bone erosion and cysts.

Measurement of proteoglycan concentration in intervertebral discs assessed by 1HMRS at 1.5T
Lisa Maria Harris1,2, Ella Hodder2,3, Mara Cercignani2, Jan Bush2, Derek Convill3, Paul Colley1, and Nicholas Dowell2
1Radiological Sciences, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom, 2Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom,3Computing, Engineering and Mathematics, University of Brighton, Brighton, United Kingdom
An assessment was made to determine whether proteoglycan concentration could accurately be quantified at 1.5T using 1HMRS in a group of 13 healthy volunteers.  A peak from the N-acetyl resonance associated with proteoglycan was seen in all thirteen spectra, and reliably measured (308.859.9).  This compares favourably with studies performed at higher field strengths, thus showing that is it possible even at 1.5T to measure proteoglycans in intervertebral discs.

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.