ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Scientific Session: Brain Motion Correction

Tuesday, May 10, 2016
Summit 1
10:00 - 12:00
Moderators: Oliver Speck, Rita Nunes

Advances in Prospective Motion Correction with Gradient Tones
Maximilian Haeberlin1, Alexander Aranovitch1, Bertram Wilm1, David Otto Brunner1, Benjamin Dietrich1, Barmet Christoph2, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, 2Skope Magnetic Resonance Technologies, Zurich, Switzerland
A system for prospective motion correction using field probes and gradient tones is presented that is independent of sequence parameters and thus compatible with clinically relevant scans. An examples of a successfully corrected MPRAGE sequence is shown and the bandwidth and the amount of unintentional head motion is measured during a 32 min. scan.

High frequency orientation estimates for fast real-time motion correction using vector observations of gravity and the static magnetic field (B0).
Adam M.J. van Niekerk1, Paul Wighton2,3, Ali Alhamud1, Matthew D. Tisdall2,3, Andre J.W. van der Kouwe2,3, and Ernesta M. Meintjes1
1Human Biology, MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, South Africa, 2Athinoula A. Martinos Center, Massachusetts General Hospital, Boston, MA, United States,3Radiology, Harvard Medical School, Boston, MA, United States
In this study we propose a novel approach to motion correction in MRI that separates the challenges of tracking orientation and translation. We developed an external hardware device capable of high frequency orientation estimates independent of the pulse sequence. The device takes vector observations of gravity and the MRI scanner’s static magnetic field (B0) and is therefore free from many constraints of some existing external motion tracking techniques. Most notably, no scanner specific calibration is required and the device can be miniaturised. Translation estimates are achieved through the use of 3 high-speed orthogonal navigators. Line by line rigid body motion correction is implemented in a spoiled gradient echo pulse sequence. 

Prospective Motion Correction Using External Tracking and Intrinsic Motion Information
Michael Herbst1,2, Aditya Singh1, Benjamin Knowles2, Maxim Zaitsev2, and Thomas Ernst1
1JABSOM, University of Hawaii, Honolulu, HI, United States, 2Medical Physics, University Medical Center Freiburg, Freiburg, Germany
Prospective motion correction with external tracking was applied to high resolution diffusion weighted imaging, using a phase-segmented EPI readout strategy. To detect and correct for residual errors during prospective motion correction, real-time volumetric registration provides continuous feedback to the acquisition.

A Comparison of 19F NMR Field Probes and an Optical Camera System for Motion Tracking
Martin Eschelbach1, Alexander Loktyushin1, Paul Chang1,2, Jonas Handwerker3, Jens Anders3, Anke Henning1,4, Axel Thielscher1,5,6, and Klaus Scheffler1,7
1High Field MR Center, Max Planck Institute for biol. Cybernetics, Tuebingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience University of Tuebingen, Tuebingen, Germany, 3Institute of Microelectronics, University of Ulm, Ulm, Germany, 4Institute for Biomedical Engineering, ETH Zürich, Zurich, Switzerland, 5Univ Copenhagen, Hvidovre Hosp, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark, 6Tech Univ Denmark, Biomed Engn Sect, Lyngby, Denmark, 7Department of Biomedical Magnetic Resonance, University Tuebingen, Tuebingen, Germany
The goal of this study is to evaluate and compare motion tracking with two different modalities: NMR field probes and an optical MPT (Moiré Phase Tracking) camera system. This was done by simultaneously measuring the manually induced motion of a spherical phantom with both systems. Our experimental results indicate that the motion patterns measured with both methods are in good agreement. However, the accuracy of the motion estimates from the field probe measurements are of an order of magnitude worse than the camera's tracking results.

Fast calculation of phase accumulation due to pulsed gradients for arbitrary rigid body motion
Patrick Hucker1, Michael Dacko1, Michael Herbst2, Ben Knowles1, and Maxim Zaitsev1
1Dept. of Radiology · Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States
A compact solution for phase calculation due to arbitrary rigid body motion based on  screw theory is presented. The proposed approach allows for rapid and quantitatively accurate calculations of the phase induced by the switching magnetic field gradients using motion tracking information e.g. from a motion tracking camera. The ability of predicting phase accumulation due to motion in presence of gradients is instrumental for achieving better correction of the motion-induced data inconsistencies for MR pulse sequences with extended signal preparation or readout periods.

Motion Detection and Correction for Carotid Artery Wall Imaging using Structured Light
Jin Liu1, Huijun Chen2, Jinnan Wang1, Niranjan Balu1, Haining Liu1, and Chun Yuan1
1University of Washington, Seattle, WA, United States, 2Tsinghua University, Beijing, China, People's Republic of
Carotid artery wall MRI is often affected by complex neck motion. We aimed to separate different motion components and correct them for better carotid artery wall delineation using structured light system. A healthy volunteer was scanned for 2D carotid MRI. It was demonstrated that voluntary abrupt motion, unconscious bulk motion and involuntary respiration can all be detected effectively. Both abrupt motion and bulk neck shift can be corrected for better vessel wall delineation, but the duration of abrupt motion can affect motion correction effectiveness. Bulk neck shift distance optimization by maximizing sharpness can future reduce motion artifact. 

Motion-corrected K-space Reconstruction for High Resolution Multi-shot Diffusion Imaging
Fuyixue Wang1, Zijing Dong1, Xiaodong Ma1, Erpeng Dai1, Zhe Zhang1, and Hua Guo1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of
Recently, several techniques have been developed to be capable of correcting shot-to-shot phase variations of multi-shot acquisition in order to obtain diffusion images with high spatial resolution. However, longer acquisition time of multi-shot EPI makes these methods more sensitive to bulk motion. In this work, we developed a novel k-space based motion corrected reconstruction method for 2D navigated multi-shot DWI. Motion simulations and in-vivo head motion experiments validated the effectiveness of the proposed method, which can remove the ghosting artifacts from minuscule motion and the blurring from bulk motion.

Robust MR eye scanning: blink detection and correction using field probes
Joep Wezel1, Anders Garpebring2, Andrew G. Webb1, Matthias J. van Osch1, and Jan-Willem M. Beenakker3
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Radiation Sciences, Umeå University, Umeå, Sweden, 3Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
Eye-blinks result in significant artifacts in ocular MRI scans, often masking important clinical pathologies, such as small ocular tumors. The aim of this study is to detect and correct for these eye-blinks. We use a fluorine-based field probe to detect these eye-blinks via changes in the local magnetic field. The field probe measurements are linked to the MR-scanner which subsequently automatically reacquires the motion-corrupted part of k-space. This method effectively corrects for the main origin of image artifacts in ocular MRI, and thereby significantly improves the image quality in a clinical setting.

Head motion tracking and correction using discrete off-resonance markers (trackDOTS) for high-resolution anatomical imaging at 7T
João Jorge1, Daniel Gallichan2, and José P Marques3
1Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Biomedical Imaging Research Center, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Donders Institute, Radboud University, Nijmegen, Netherlands
High-resolution imaging can be significantly affected by subject head motion. Here, we demonstrate the use of discrete off-resonance MR markers (“trackDOTS”) in head motion tracking and correction, for high-resolution anatomical imaging. This approach relies on fast 1D-projection acquisitions (under 50ms per measurement) which do not disturb the water signal. These measurements were incorporated in an MP2RAGE sequence, and a 0.6mm isotropic resolution image was acquired from a healthy subject. Motion timecourses estimated from the trackDOTS positions matched concomitant estimations performed with FatNavs (with deviations of 0.09±0.08mm for translations and 0.20°±0.19° for rotations); MP2RAGE image quality was visibly improved upon correction.

Amplified Magnetic Resonance Imaging (aMRI)
Samantha J Holdsworth1, Wendy W Ni1, Greg Zaharchuk1, Michael E Moseley1, and Mahdi S Rahimi1
1Lucas Center for Imaging, Department of Radiology, Stanford University, Palo Alto, CA, United States
This work introduces a new visualization method called amplified Magnetic Resonance Imaging (aMRI), which uses Eulerian Video Magnification to amplify subtle spatial variations in cardiac-gated brain MRI scans and magnify brain motion. This approach reveals deformations of brain structures and displacements of arteries due to cardiac pulsatility, especially in the brainstem, cerebellum, and spinal cord. aMRI has the potential for widespread neuro- and non-neuro clinical application, because it can amplify and characterize barely perceptible motion, and allows visualization of biomechanical responses of tissues using the heartbeat as an endogenous mechanical driver.

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