ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Scientific Session: Body Diffusion

Thursday, May 12, 2016
Room 324-326
10:30 - 12:30
Moderator: Valentina Taviani

Differentiation of Pancreatic Carcinoma and Mass-forming focal pancreatitis: assessment by dynamic contrast-enhanced MRI combined with diffusion-weighted imaging
Tingting Zhang1 and Dengbin Wang1
1Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong Medical University, Shanghai, China, Shanghai, China, People's Republic of
This study is to access the differential value in Pancreatic Carcinoma (PC) and Mass-Forming focal Pancreatitis (FP) with qualitative and quantitative analysis of DCE-MRI and DWI. Pancreatic TIC types and sub-types from DCE-MRI and ADC value and tumor-to-pancreas contrast ratio of ADC value from DWI were compared between PC and FP. We found significant differences in TIC and ADC value and ADC tumor-to-pancreas contrast ratio between PC and FP. DCE-MRI and DWI were discovered to provide reliable information for differentiating PC from FP, while the combination of them can achieve a higher sensitivity and specificity.

The potential of apparent diffusion coefficient in differentiating various sub-types of breast tumors and its association with hormonal status
Khushbu Agarwal1, Rani Gupta Sah1, Uma Sharma1, Smriti Hari2, Sandeep Mathur3, Vurthaluru Seenu4, Rajinder Parshad4, and Naranamangalam R Jagannathan1
1Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, 2Department of Radio-diagnosis, All India Institute of Medical Sciences, Delhi, India, 3Department of Pathology, All India Institute of Medical Sciences, Delhi, India, 4Department of Surgical Disciplines, All India Institute of Medical Sciences, Delhi, India
Potential of apparent diffusion coefficient (ADC) in differentiating various sub-types of malignant and benign breast tumors using diffusion weighted MRI and its association with different hormonal status in breast cancer patients was studied. A significantly lower ADC of malignant compared to benign and healthy breast tissues was observed. The ADC of fibroadenomas was lower compared to fibrocystic with fibroadenoma and cystic lesions and higher in cystic and fibrocystic lesions than benign ductal epithelial cells. No association of ADC with molecular biomarkers ER, PR and Her2neu was seen. Results showed the utility of ADC in differentiating various types of breast tissues.

Intravoxel Incoherent Motion DWI and Aquaporins MR Imaging of Transplanted Kidneys at 3.0 T
Yanjun Li1, Shumin Tao1, Dandan Zheng2, Yong Zhang2, and Guangming Lu1
1Medical Imaging, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China, People's Republic of, 2GE Healthcare, MR Research China, Beijing, China, People's Republic of
Diffusion-weighted imaging (DWI) in human transplantation was regarded as a promising indicator for dectecting graft dysfunction.According to the IVIM theory, ADC integrates the effects of both diffusion of water molecules and microcirculation of blood in capillaries. By separating diffusion and perfusion, we could observe each component’s contribution to the changes of ADC values. Furthermore, the exchanges of intracellular water molecules with extracellular’s may have impact on ADC. Thus, AQP ADC might reflect quantitative water channel expression.

The Diffusion and Perfusion Characteristics of Placenta with Differential Fetal Growth Restriction Types Using Intravoxel Incoherent Motion MR Imaging
TANG Min1, Xiaoqin LIU1, Xiaoling ZHANG1, Kaining Shi2, and Kaining Shi2
1Shaanxi Provincial People`s Hospital, Xi’an, China, People's Republic of, 2Clinical science, Philips Healthcare China, Xi’an, China, People's Republic of
The purpose of this study is to explore the feasibility of assessing perfusion and diffusion information of placenta with different FGR types using Intravoxel Incoherent Motion MR Imaging .we find that there are different diffusion and perfusion characteristic in different in placenta of FGR hypotype.  

Improved IVIM MRI of Small Lesions in the Liver by Deformable Image Registration with Modality Independent Neighborhood Descriptor
Yihao Guo1, Zhentai Lu1, Yingjie Mei2, Jing Zhang3, Yikai Xu3, Feng Huang4, Ed. X. Wu5,6, and Yanqiu Feng1,5,6
1School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, GuangZhou, China, People's Republic of, 2Philips Healthcare, GuangZhou, China, People's Republic of, 3Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, GuangZhou, China, People's Republic of, 4Philips Healthcare(Suzhou), Suzhou, China, People's Republic of, 5Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, People's Republic of, 6Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, People's Republic of
Respiration-induced misalignment between multiple b-value liver DW image scan severely reduce the accuracy and stability of IVIM parameter quantification, especially in the presence of small focal lesions. These small lesions usually exhibit significantly differentintensity in different b-value images, but have similar structural information.  This work introduces modality independent neighborhood descriptor to extract the structural information of small lesions for improved realignment between multiple b-value images.  Preliminary results show that this structure-based registration method can well correct respiration-induced misalignment between multiple b-value images with small lesions, improve the IVIM model fitting quality, and reduce variance in quantified parameters. 

Diffusion Tensor Imaging and Histology of the Developing Myocardium
Osama M Abdullah1, MarJanna Dahl2, Gavin Yeip1, Julia Cortino1, Arnold David Gomez3, Thomas Seidel1, Frank Sachse1, Kurt Albertine2, and Edward W Hsu1
1Bioengineering, University of Utah, Salt Lake ity, UT, United States, 2Pediatric Neonatology, University of Utah, Salt Lake ity, UT, United States, 3Electrical and Computer Engineering, Johns Hopkins, Baltimore, MD, United States
Diffusion tensor imaging (DTI) has emerged as the method of choice for noninvasive quantifications of myocardial microstructure. However, the origins and behaviors of DTI measurements as functions of myocardial remodeling during development remain poorly understood. In this work, conventional and bi-compartmental DTI and histological correlation were performed on an animal model of myocardial development to investigate the effects of tissue remodeling. Results indicate that tissue remodeling during development manifests in progressively increased DTI transverse diffusivities, decreased fractional anisotropy, and unchanged fiber orientation. The findings show that DTI can be used to noninvasively characterize microstructural remodeling of the myocardium during development.

Comparing the breath-hold, respiratory-triggered and free-breathing techniques in the diffusion-weighted imaging for the evaluation of focal liver lesions on a 3.0T system
Zhuo Shi1, Xinming Zhao1, Ouyang Han1, and Lizhi Xie2
1Department Of Imaging Diagnosis,Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing China, Beijing, China, People's Republic of, 2GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of
DWI plays an important role in detecting and characterizing liver lesions or tumors. There are three kinds of liver DWI acquisitions are commonly used in hepatic DWI: breath-hold , respiratory-triggered,free-breathing. This work compares the advantages and disadvantages of diagnosing focal liver lesions, to find the best acquisition sequence for different situations.

Study of Spatial Function in the Human Placenta with Diffusion Weighted Imaging
Edward Sutherland 1, Luís F Gonçalves1,2,3, and Yuxiang Zhou1,3
1William Beaumont Hospital School of Medicine, Oakland University, Rochester, MI, United States, 2Department of Obstetrics and Gynecology, Beaumont Health, Royal Oak, MI, United States, 3Diagnostic Radiology and Molecular Imaging, Beaumont Health, Royal Oak, MI, United States
Magnetic resonance diffusion weighted imaging (DWI) has been widely used to quantitatively measure the random motion of water molecules within a voxel of tissue and represents this information in the form of apparent diffusion coefficient (ADC) maps. As the ADC map has been shown to be influenced by circulatory motion and perfusion at low b-values, we hypothesize that ADC values obtained from the placenta may vary as a function of distance to the umbilical cord insertion. In this retrospective study, 78 healthy placentas were evaluated by MR-DWI. We conclude that ADC values of placental tissues obtained at high b-values do not vary in normal human placentas as a function of distance to umbilical cord insertion.

Comparison of multi-component restricted and anisotropic models of diffusion in glandular breast tissue
Sisi Liang1, Narina Norddin2, Eleftheria Panagiotaki 3, Andre Bongers4, Peng Shi1, Laurence Gluch5, and Roger Bourne2
1College of Engineering and Science, Victoria University, Melbourne, Australia, 2Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia, 3Center for Medical Image Computing, University College London, London, United Kingdom, 4Biological Resource Imaging Laboratory, University of New South Wales, Sydney, Australia, 5The Strathfield Breast Centre, Strathfield, Australia
DWI signal attenuation measured in biological tissue is widely observed to be non-monoexponential. One important diffusion characteristic underlying that complex behavior is restriction and hindrance to water diffusion.  This study compared multi-component restricted and unrestricted models of diffusion in the glandular part of breast tissue. The results show that multi-component restricted and anisotropic models explain the data best. This finding is consistent with the presence of distinct diffusion microenvironments in breast tissue. Development of clinical DWI methods that incorporate these features may improve breast cancer assessment.

Evaluation of the levator ani muscle in primiparas six weeks after vaginal delivery using diffusion tensor imaging and fiber tractography
Can Cui1, Yujiao Zhao1, Yu Zhang 2, and Wen Shen3
1Radiology, Tianjin First Center Clinical College, Tianjin Medical University, Tianjin, China, People's Republic of, 2Philips Healthcare, Beijing, China, People's Republic of, 3Radiology, Tianjin First Center Hospital, Tianjin, China, People's Republic of
The aim of this study was to investigate the clinical application of DTI fiber tractography on evaluating the levator ani injury after first vaginal delivery. Thirty-five primiparous women with 6 weeks after vaginal delivery and twenty-five age-matched nulliparous women volunteers as control group were included. The primiparas women were divided into 2 subgroups by the existence of pelvic organ prolapse. DTI with fiber tractography provided satisfactory 3D representation of pubovisceralis while the study of iliococcygeus was more difficult. No significant differences of FA and ADC values were found among primiparous normal group, primiparous POP group and control group for pubovisceralis.

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