ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Scientific Session: Young Investigator Awards

Monday, May 9, 2016
Room 331-332
10:45 - 12:45
Moderators: Brian Hargreaves, Jennifer McNab

Music-Based Magnetic Resonance Fingerprinting to Improve Patient Comfort During MRI Examinations
Dan Ma1, Eric Y. Pierre2, Yun Jiang 2, Mark D. Schluchter3, Kawin Setsompop4, Vikas Gulani1, and Mark Griswold1
1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, OH, United States, 4A.A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States
An acquisition method named MRF-Music is proposed to mitigate the acoustic noise during MRI scans by producing musical sounds directly from the switching magnetic fields while simultaneously quantifying multiple important tissue properties. MP3 music files were converted to arbitrary encoding gradients, which were then used with varying flip angles and TRs in both 2D and 3D MRF exam to generate T1, T2 and proton density maps. The MRF-Music scans were shown to significantly improve patients’ comfort. T1 and T2 measured from phantom and in vivo scans were also in good agreement with those from the standard measurements and reported values. 

Simultaneous assessment of cardiac metabolism and perfusion using co-polarized [1-13C]pyruvate and 13C-urea
Angus Zoen Lau1,2, Jack Miller2,3, Matthew D Robson1, and Damian J Tyler1,2
1Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom, 3Department of Physics, Clarendon Laboratory, Oxford, United Kingdom
Assessment of cardiac metabolism and perfusion using hyperpolarized 13C substrates enables discrimination between viable, hibernating, and non-viable tissue, but current methods require two separate injections of pre-polarized [1-13C]pyruvate and 13C-urea, respectively. We propose to use an infusion of co-polarized [1-13C]pyruvate/13C-urea combined with a flow-sensitized pulse sequence to simultaneously assess both of these parameters in a single injection. Perfusion and metabolic state are modulated using specific interventions, and subsequently detected using the new scan. This probe of both myocardial perfusion and metabolism is anticipated to enable metabolic study of the heart in acute scenarios.

xSPEN: Single-shot magnetic resonance imaging with exceptional resilience to field heterogeneities
Zhiyong Zhang1, Amir Seginer1, and Lucio Frydman1
1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
Single-shot MRI has been constrained to acquisitions in quality magnets and homogeneous tissues. The present study introduces a methodology that can deliver such images with good SNR, under much poorer field and/or multiple shift conditions. These capabilities are achieved based on new principles whereby images are read using field gradients that are not applied along the direction being encoded. This enables one to accommodate shifts/inhomogeneities into the single-scan image generation protocol, without suffering from miss-registrations, without requiring a priori information for post-acquisition corrections, and without demanding specialized instrumentation. This enables new single-shot investigations that have hitherto escaped from MRI’s scope.

Evaluation of Upper Airway Collapsibility Using Simultaneous Multi-Slice Real-Time MRI
Ziyue Wu1,2, Weiyi Chen1, Michael C.K. Khoo1, Sally L. Davidson Ward3, and Krishna S. Nayak1
1University of Southern California, Los Angeles, CA, United States, 2Alltech Medical Systems, Solon, OH, United States, 3Children's Hospital Los Angeles, Los Angels, CA, United States
We present a method for simultaneous multi-slice airway collapsibility measurement based on sparse golden-angle radial CAIPIRINHA, with acceleration factor up to 33.3. We present data from patients with obstructive sleep apnea and normal controls.  One interesting finding is that a narrower airway site does not always correspond to higher collapsibility. This finding may be of interest to sleep surgeons. Our results also suggest that both compliance and Pclose were significantly different between healthy controls and OSA patients (P<0.001), and both measures can potentially serve as biomarkers.

Interstudy repeatability of self-gated quantitative myocardial perfusion MRI
Devavrat Likhite1, Promporn Suksaranjit2, Ganesh Adluru1, Nan Hu3, Cindy Weng3, Eugene Kholmovski1, Chris McGann2, Brent Wilson2, and Edward DiBella1
1Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, United States, 2Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, United States,3Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States
Dynamic contrast enhanced MRI is maturing as a tool in contemporary cardiovascular medicine. A self-gated method that avoids the use of ECG-gating signal has been validated by us for quantitative myocardial perfusion. Our most recent study looks at the inter-study repeatability of this quantitative self-gated method. Our findings show that the multi-slice self-gated (near-systole) approach has a comparable or better repeatability than published ECG-gated single slice studies. The purpose of this abstract is to summarize these findings from our recent work, highlighting the simplicity, ease of use and reliability of the self-gated method for quantitative myocardial perfusion.

Neurovascular uncoupling in resting state fMRI demonstrated in patients with primary brain gliomas
Shruti Agarwal1, Haris I. Sair1, Noushin Yahyavi-Firouz-Abadi1, Raag Airan1, and Jay J. Pillai1
1Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States
One of the most important potential limitations of presurgical mapping using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) is the phenomenon of neurovascular uncoupling (NVU). NVU can lead to erroneous interpretation of clinical fMRI examinations. The effects of brain tumor-related NVU on task-based BOLD fMRI have been previously published. The purpose of this study is to demonstrate that the problem of brain tumor-related NVU is a significant issue with respect to resting state BOLD fMRI similar to task-based BOLD fMRI, in which signal detectability can be compromised by breakdown of normal neurovascular coupling.

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