ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Power Pitch Session: Body MRI

Wednesday, May 11, 2016
Power Pitch Theatre, Exhibition Hall
16:00 - 18:00
Moderators: Masoom Haider, Edwin van Beek

Click Here to view the Power Pitch introductory session

Note: The videos below are only the slides from each presentation.
They do not have audio.

    Plasma #

1 Abdominal and Body Imaging Using a 16 Channel Dipole RF Array at 7.0 T
Celal Oezerdem1, Till Huelnhagen1, Lukas Winter1, and Thoralf Niendorf1,2
1Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, 2Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
This pilot study demonstrates the feasibility of abdominal imaging and parametric T2* mapping of the liver and kidney at 7.0T by employing a 16 channel electrical dipole RF array. The large field of view and rather uniform excitation field enabled by the proposed bow tie antenna array affords comprehensive anatomic coverage and enhanced spatial resolution. Our initial results suggest that high spatial resolution anatomic and functional UHF-MR can be of benefit for clinical liver and kidney imaging.

2 Free-Breathing 3D Abdominal Magnetic Resonance Fingerprinting Using Navigators
Yong Chen1, Bhairav Mehta1, Jesse Hamilton2, Dan Ma1, Nicole Seiberlich2, Mark Griswold1, and Vikas Gulani1
1Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States
In this study, a free-breathing quantitative abdominal imaging method was developed using the MRF technique in combined with navigators, which allows simultaneous and volumetric quantification of multiple tissue properties in abdomen.

3 Multiple Linear Regression for Predicting Fibrosis in the Kidney using T1 Mapping and ‘RESOLVE’ Diffusion-Weighted MRI
Iris FRIEDLI1, Lindsey Alexandra CROWE1, Lena BERCHTOLD2, Solange MOLL3, Karine HADAYA2, Thomas DE PERROT1, Pierre-Yves MARTIN2, Sophie DE SEIGNEUX2, and Jean-Paul VALLEE1
1Department of Radiology, Geneva University Hospitals, Geneva, Switzerland, 2Department of Nephrology, Geneva University Hospitals, Geneva, Switzerland, 3Department of Pathology, Geneva University Hospitals, Geneva, Switzerland
Multi-parametric studies are beginning to emerge in renal disease assessment. However these studies investigated each MR parameter independently and compare the MR sequences but do not combine multiple parameters in a single statistic. In this multi-parametric 3T MR study, the sensitivity of T1 mapping and Readout Segmentation Of Long Variable Echo train (RESOLVE) DWI parameters was first independently evaluated and compared against interstitial fibrosis of 31 Chronic Kidney Disease patients undergoing renal biopsy. The two MR parameters were then associated in a single statistic with the hypothesis that used together they can improve the non-invasive detection of interstitial fibrosis. 

4 Towards Quantitative Renal MR Blood Oximetry by Combined Monitoring of T2*, T2 and Blood Volume Fraction
Andreas Pohlmann1, Karen Arakelyan1,2, Leili Riazy1, Till Huelnhagen1, Stefanie Kox1, Kathleen Cantow2, Sonia Waiczies1, Bert Flemming2, Erdmann Seeliger2, and Thoralf Niendorf1
1Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute of Physiology, Charite Universitaetsmedizin, Berlin, Germany
Acute kidney injuries are often characterized by tissue oxygen hypoxia. T2*-mapping permits probing renal oxygenation but provides a surrogate rather than a quantitative measure of oxygen saturation. The link between pO2 and T2* is influenced by changes in blood volume fraction (BVf). Monitoring BVf in combination with recently developed quantitative BOLD approaches could permit unambiguous interpretation of renal T2*. To test the feasibility of this new approach we monitored renal T2*/T2 during baseline and short periods of venous occlusion. This was performed in the same animal under naïve conditions and again with USPIO to permit estimation of BVf and SO2.

5 BOLD MRI of human placenta and fetuses under maternal hyperoxygenation in growth restricted twin pregnancies
Jie Luo1,2, Esra Abaci Turk1,2, Carolina Bibbo3, Borjan Gagoski1, Mark Vangel4, Clare M Tempany-Afdhal5, Norberto Malpica6, Arvind Palanisamy7, Elfar Adalsteinsson2,8,9, Julian N Robinson3, and Patricia Ellen Grant1
1Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2Madrid-MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Maternal and Fetal Medicine, Brigham and Women's Hospital, Boston, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, 6Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain, 7Division of Obstetric Anesthesia, Brigham and Women's Hospital, Boston, MA, United States, 8Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 9Harvard- MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States
Adequate oxygen transport across the placenta from mother to fetus is critical for fetal growth and development. In this pilot study, BOLD MRI with maternal hyperoxygenation show great potential in differentiating IUGR fetuses from controls. Not only the placentae show significant difference in rate of oxygen uptake, fetal organs also have distinct response to exposure to hyperoxia. Differences between fetal brain and liver responses to hyperoxygenation are observed in some cases, which might suggest variations in fetal hemodynamic autoregulation. 

6 Ingestion of carbohydrate solutions of glucose-fructose versus glucose-alone during a prolonged exercise in individuals with type 1 diabetes
Tania Buehler1, Lia Bally2, Ayse Sila Dokumaci1, Christoph Stettler2, and Chris Boesch1
1Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland, 2Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital Bern, Bern, Switzerland
In comparison to healthy subjects, there is scarce data on the influence of different carbohydrate-types on the metabolism in exercising individuals with type 1 diabetes mellitus (T1DM). Based on 13C-MRS, blood sampling, stable isotopes, and indirect calorimetry the impact of glucose-fructose and glucose-alone was investigated in T1DM subjects without prior insulin reduction. Glucose-fructose ingestion showed a shift in fuel metabolism towards increased fat oxidation and potential glycogen sparing effects. Despite the negative reputation of fructose it seems to be a more efficient fuel in exercising T1DM subjects, since blood glucose levels are not immediately elevated due to its different metabolization.

7 Pancreatic disease in obesity: observations on fat content, diffusion, T2* relaxometric and mechanical properties in the rat ex vivo
Philippe Garteiser1, Sabrina Doblas1, Jean-Baptiste Cavin1, André Bado1, Vinciane Rebours1,2, Maude Le Gall1, Anne Couvelard1,3, and Bernard E Van Beers1,4
1Center For Research on Inflammation, Inserm U1149, Paris, France, 2Pancreatology Unit, AP-HP, Beaujon Hospital, Clichy, France, 3Pathology department, AP-HP, Bichat Hospital, Paris, France,4Radiology department, AP-HP, Beaujon Hospital, Clichy, France
Multiparametric assessment of pancreas in the obese rat was used to evaluate alterations linked to obesity-mediated inflammation. Mechanical properties and T2* values are significantly affected by disease, and reflect accurately the histological features of the obese pancreas.

8 MR of hyperpolarized Xe-129 dissolved in the human brain at 1.5 T and 3.0 T
Madhwesha Rao1, Neil J Stewart1, Graham Norquay1, Paul D Griffiths1, and Jim M Wild1
1Academic unit of Radiology, University of Sheffield, Sheffield, United Kingdom
Xenon is an inert noble gas which can be safely inhaled. In the lungs, it diffuses into the bloodstream and is then transported to distal organs (brain, kidneys and liver). In this study, we have directly imaged the uptake of hyerpolarized 129Xe in the human brain in vivo. Thus demonstrated the feasibility as a safe and non-invasive contrast agent for functional imaging of the brain in diagnosing diseases related to cerebral perfusion such as brain ischemia. In addition, using tracer kinetic analysis we provide quantitative measurement for the intrinsic physiological characteristic of the blood brain barrier.

9 Pulmonary Thin-Section MRI with Ultrashort TE: Capability for Lung Nodule Screening and Subtype Classification as Compared with Low- and Standard-Dose CTs - Permission Withheld
Yoshiharu Ohno1,2, Yuji Kishida2, Shinichiro Seki2, Hisanobu Koyama2, Takeshi Yoshikawa1,2, Daisuke Takenaka3, Masao Yui4, Aiming Lu5, Mitsue Miyazaki5, Katsusuke Kyotani6, and Kazuro Sugimura2
1Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, 2Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Radiology, Hyogo Cancer Center, Akashi, Japan, 4Toshiba Medical Systems Corporation, Otawara, Japan, 5Toshiba Medical Research Institute USA, Vernon Hills, IL, United States, 6Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan
    MRI with ultrashort TE (UTE) has been suggested as useful for morphological assessment of lung as well as CT.  However, no reports have been found to study the capability of thin-section MRI with UTE for pulmonary nodule detection and nodule type assessment as compared with thin-section CTs.  We hypothesized that pulmonary MRI with UTE has a similar potential for nodule detection and nodule type evaluation as compared with thin-section CT.  The purpose of this study was to compare the capability of pulmonary MRI with UTE for nodule detection and nodule type assessment with low- and standard-dose CTs.

10 Quantitative Assessment of Pulmonary Blood Flow in Infants with Congenital Diaphragmatic Hernia by CINE Phase Contrast MRI
Jean A Tkach1, Ryan A Moore2, Nara S Higano1,3,4, Laura L Walkup1,3, Mantosh S Rattan5, Paul S Kingma6, Michael D Taylor2, and Jason C Woods1,3,4
1Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Department of Physics, Washington University, St. Louis, MO, United States, 5Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 6Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
Pulmonary arterial hypertension (PAH) is common in congenital diaphragmatic hernia (CDH) and is a major contributor to morbidity and mortality. Echocardiography and cardiac catheterization are the current standards for evaluating pulmonary hemodynamics in CDH infants, but both have significant limitations and/or risks. Phase contrast (PC) MRI can provide quantitative information about velocity and flow longitudinally, with minimal risk.  We demonstrate the feasibility of applying PC MRI in the neonatal ICU (NICU) to obtain a quantitative assessment of pulmonary blood flow in CDH infants with the long-term goal to establish imaging biomarkers to predict PAH and assess therapeutic response. 

11 Pretreatment intravoxel incoherent motion diffusion-weighted imaging for predicting the response of locally advanced rectal cancer to neoadjuvant chemoradiation therapy
Hongliang Sun1, Yanyan Xu1, Kaining Shi2, and Wu Wang1
1Radiology, China-Japan Friendship hospital, Beijing, China, People's Republic of, 2Philips Healthcare China, Beijing, China, People's Republic of
Neoadjuvant chemoradiation therapy (CRT) followed by surgery has been established as the standard for locally advanced rectal cancer[1]. The treatment response after CRT is normally evaluated by MRI. However, MRI morphology techniques suffer from limitations in the interpretation of fibrotic scar tissue and inflammation. Diffusion weighted MRI has shown its potentially beneficial role for response evaluation, but with conflicting results[2]. Intravoxel incoherent motion (IVIM) which enable quantitative parameters that separately reflect tissue diffusivity and tissue microcapillary perfusion[3-4]. However, the pretreatment tumor IVIM MRI parameters predicting treatment response were not clarified.

12 Prostate cancer detection with multi-parametric MRI : PI-RADS version 1 versus version 2
Zhaoyan Feng1, Xiangde Min1, and Liang Wang1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, People's Republic of
 The new PI-RADS version 2 classification (PI-RADS v2) was proposed together with the European Society of Urogenital Radiology (ESUR) and the American College of Radiology (ACR) in December 2014. In contrast to PI-RADS v1, the v2 regulate how to classify final PI-RADS score. for routine clinical use, test of the validity of v2, including its sensitivity and specificity for prostate cancer (PCa) detection should raise concerns, and literature of them less. So, the purpose of our study was to compare the diagnostic performance of v1 and v2 for the detection of PCa.

13 Radiomic features on T2w MRI to predict tumor invasiveness for pre-operative planning in colorectal cancer: preliminary results
Jacob Antunes1, Scott Steele2, Conor Delaney2, Joseph Willis3, Justin Brady4, Rajmohan Paspulati5, Anant Madabhushi1, and Satish Viswanath1
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Department of Colon and Rectal Surgery, University Hospitals Case Medical Center, Cleveland, OH, United States, 3Department of Anatomic Pathology, University Hospitals Case Medical Center, Cleveland, OH, United States, 4Department of General Surgery, University Hospitals Case Medical Center, Cleveland, OH, United States, 5Department of Radiology, University Hospitals Case Medical Center, Cleveland, OH, United States
Pre-operative planning in colorectal cancer is highly dependent on extent of tumor into the mesorectum, but tumor margin is currently only assessed on excised pathology. Radiomic features may capture subtle microarchitectural changes on a restaging MRI, enabling characterization of tumor extent prior to surgery, even when residual disease may not be visually discernible. We present preliminary results for identifying radiomic features which discriminate invasive from noninvasive tumor on a 3 Tesla restaging T2w MRI in colorectal cancer. In a cohort of 24 patients, multi-scale gradient (Gabor) radiomic features demonstrated high accuracy in segregating patients with invasive colorectal cancer.

14 Motion Compensated Diffusion-Weighted MRI in the Liver with Convex Optimized Diffusion Encoding (CODE)
Eric Aliotta1,2, Holden H Wu1,2, and Daniel B Ennis1,2
1Radiological Sciences, UCLA, Los Angeles, CA, United States, 2Biomedical Physics IDP, UCLA, Los Angeles, CA, United States
Bulk motion artifacts in liver DWI can be substantially reduced with first moment nulled diffusion encoding. However, the bipolar diffusion encoding gradient waveforms generally used for this purpose extend TE and limit SNR. We have developed a Convex Optimized Diffusion Encoding (CODE) framework to design time-optimal, motion compensated diffusion encoding gradients that remove sequence dead times and minimize TE. CODE gradients were designed and implemented for liver DWI on a 3.0T clinical scanner, then evaluated in healthy volunteers and patients. Bulk motion artifacts were significantly reduced and  ADC maps were improved compared to conventional monopolar encoding.

15 Quantitative Analysis of Arterial Phase Transient Respiratory Motions Induced by Two Contrast Agents for Dynamic Liver MR Imaging
Yuxi Pang1, Dariya Malyarenko1, Matthew Davenport1, Hero Hussain1, and Thomas Chenevert1
1Department of Radiology, UNIVERSITY OF MICHIGAN, ANN ARBOR, MI, United States
This work is to analyze the respiratory waveforms from dynamic liver MR images related to the motion artifacts in arterial phase images induced by the contrast-media administration. The discriminative metrics were defined to quantify the likelihood of the acutely and temporally impaired breath-holding by the subjects who received gadoxetate disodium and gadobenate dimeglumine contrast agents. Our preliminary results show that the indicative metrics derived from recorded respiratory waveforms objectively confirm prior reported observations that gadoxetate disodium has a significantly higher likelihood of inducing acute transient breath-holding difficulties that adversely affect arterial phase image quality.

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