ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Power Pitch Session: Top CV's

Tuesday, May 10, 2016
Power Pitch Theatre, Exhibition Hall
16:00 - 18:00
Moderators: Jeff Maki, Chun Yuan

Click Here to view the Power Pitch introductory session

Note: The videos below are only the slides from each presentation.
They do not have audio.

    Plasma #

16 Dual-modal cardiovascular in vivo assessment in rats using a highly integrated MPI-MRI hybrid system – initial result
Jochen Franke1,2, Nicoleta Baxan3, Ulrich Heinen1, Alexander Weber1,4, Heinrich Lehr1, Martin Ilg1, Wolfgang Ruhm1, Michael Heidenreich1, and Volkmar Schulz2
1Preclinical Imaging Devision, Bruker BioSpin MRI GmbH, Ettlingen, Germany, 2Physics of Molecular Imaging Systems, University RWTH Aachen, Aachen, Germany, 3Biomedical Imaging Centre, Imperial College London, London, United Kingdom, 4Institute of Medical Engineering, University of Lübeck, Lübeck, Germany
Using a highly integrated Magnetic Particle Imaging – Magnetic Resonance Imaging hybrid system, a dual-modal cardiovascular in vivo assessment in rodents under the usage of a non-toxic Resovist dosage was performed successfully. The subject was imaged sequentially in both modality modes, whereas neither subject repositioning nor anesthesia interruption were required. Complementary datasets were acquired within a single seamless multi-modal study using ParaVison6 (Bruker BioSpin, Germany) allowing direct MRI-based MPI Field-of-View planning. After reconstructing time-resolved (TR=21.45 ms) 3D MPI images of the bolus-passage they were successfully fused with a high-resolution static 3D MRI dataset and visualized as combined 4D/3D hybrid dataset.

1 Hybrid Interleaved Multi-contrast Imaging (HIMI) for Simultaneous Brain and Carotid Vessel Wall Imaging
Shuo Chen1, Zechen Zhou1, Rui Li1, Xihai Zhao1, Huijun Chen1, Changwu Zhou1,2, Bida Zhang3, and Chun Yuan1,4
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, 2Department of Radiology, Yangzhou First People's Hospital, Yangzhou, China, People's Republic of, 3Healthcare Department, Philips Research China, Shanghai, China, People's Republic of, 4Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States
The aim of this study was to develop a Hybrid Interleaved Multicontrast Imaging (HIMI) sequence for simultaneous brain and carotid vessel wall imaging. The proposed HIMI sequence takes advantage of the long delay time in conventional 3D FLAIR sequence to acquire multi-contrast carotid vessel wall images. Four healthy volunteers were recruited in this study. The results indicate that HIMI can generate a comparable FLAIR image with conventional FLAIR sequence and three more different contrast weighted (T1w, T2w, gray blood) carotid vessel wall images with the same scan time as a single conventional 3D FLAIR sequence.

2 How Accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?
Jerome Yerly1,2, Danilo Gubian3, Jean-Francois Knebel2,4, Thomas Robin5, Giulia Ginami1, and Matthias Stuber1,2
1CardioVascular Magnetic Resonance (CVMR) research center, Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 3University Hospital (CHUV), Lausanne, Switzerland, 4Laboratory for Investigative Neurophysiology (The LINE), Departments of Radiology and Clinical Neurosciences, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 5Transport and Mobility Laboratory (TRANSP-OR), Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland
MRI with isometric handgrip exercise was recently proposed to non-invasively assess coronary endothelial function. However, the sensitivity of this technique has not yet been fully investigated. To address this need, we have designed a phantom that simulates a physiological range of coronary cross-sectional areas. Radial cine MR images with different spatial resolutions were acquired under moving conditions. Cross-sectional areas were automatically measured and compared to the known nominal values. Statistical analysis suggests that MRI is capable of distinguishing area changes in the order of 0.2-0.3mm2, which correspond to a percentage coronary area change of 3-4% for a 3mm baseline diameter.

3 Evaluation of lower extremity arteries with severe wall calcification in peripheral arterial disease (PAD); comparison of Fresh blood imaging (FBI) with CT angiography with using a commercially available calcification removable tool
Katsumi NAKAMURA1,2, Akiyoshi Yamamoto1, Hiroki Matoba1, Yuji Shintani1, Daiji Uchiyama1, Seigo Yoshida1, and Mitsue Miyazaki3
1Radiology, Tobata Kyoritsu Hospital, Kitakyushu, Japan, 2Nexus Image Lab, Kitakyushu, Japan, 3Toshiba Medical Research Institute USA, Inc., Vernon Hills, IL, United States
We compared the diagnostic ability of FBI with that of CTA  with using a calcification removal tool in the evaluation of the lower-extremity arteries with wall calcifications. In all segments, FBI provided diagnostic images regardless of the degree of wall calcification.  On the contrary, CTA-MIP and CTA-MIP w/o Ca were strongly affected by calcification. The diagnostic ability of FBI was significantly superior to that of CTA-MIP and CTA-MIP w/o Ca in the moderate to severe calcified arterial segments. In conclusion, FBI is an accurate and noninvasive alternative to CTA for the assessment of aortoiliac and lower extremity arteries in patients with PAD.

4 A Novel Concept for Motion Suppression Applied to Free-Breathing 3D Whole-Heart Coronary MRA: Respiratory Motion-Resolved Reconstruction
Davide Piccini1,2, Li Feng3, Gabriele Bonanno2, Simone Coppo2, Jérôme Yerly2,4, Ruth P. Lim5, Juerg Schwitter6, Daniel K. Sodickson3, Ricardo Otazo3, and Matthias Stuber2,4
1Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, 2Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland,3Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York City, NY, United States, 4Center for Biomedical Imaging (CIBM), Lausanne, Switzerland,5Department of Radiology, Austin Health and The University of Melbourne, Melbourne, Australia, 6Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
We hypothesize that sparse reconstruction algorithms can be exploited to reconstruct respiratory motion-resolved 3D MRA images of the heart without the need for breath-holding, navigators, or self-navigated respiratory motion correction. Phantom, volunteer, and patient acquisitions were performed and image quality was compared to 1D self-navigation for vessel sharpness, length and diagnostic quality. Respiratory motion-resolved reconstruction effectively suppresses respiratory motion artifacts with superior results with respect to self-navigation. Instead of discarding data or enforcing motion models for motion correction, motion-resolved reconstruction makes constructive use of all respiratory phases to improve image quality, and may lead coronary MRA closer to clinical practice.

5 Preliminary Results: Cardiac Cine “Watermark” MRI provides both Anatomical Function via Magnitude Cine and 2D Myocardial Strain via Spatially Modulated Phase
Ronald J Beyers1, Davis M Vigneault2, Dean Schwartz3, Nouha Salibi1,4, David A Bluemke2, and Thomas Denney1
1MRI Research Center, Auburn University, Auburn University, AL, United States, 2Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, 3Anatomy, Physiology and Pharmacology, Auburn University, Auburn University, AL, United States, 4MR R&D, Siemens Healthcare, Malvern, PA, United States
We developed a Cine Watermark (CWM) cine sequence that produces normal cine magnitude images, plus a grid pattern of tags added only in the phase for quantitative cine strain, while requiring no extra operator effort.  Using spatial cosine modulation combined with k-space sum/differencing produced separate normal magnitude cine and unique phase-only grid-tags for strain calculation.  In vivorat and human scans demonstrated good magnitude cine and phase-only quantified displacement. Calculated by Farneback optical flow algorithm, the peak principle strain, averaged around the LV for rat = -16.5±2.4 % and human = -17.8±6.2 % (mean±StdDev).

6 Fetal cardiac cine imaging from motion-corrected super-resolution reconstruction of highly-accelerated real-time MRI
Joshua FP van Amerom1, Maria Kuklisova Murgasova1, Anthony N Price1, Shaihan J Malik1, Paul Aljabar2, David A Lloyd1, Kuberan Pushparajah1,3, Maelene Lohezic1, Matthew J Fox2, Joanna M Allsop2, Mary A Rutherford1,2, Reza Razavi1,3, and Joseph V Hajnal1
1Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 2Centre for the Developing Brain, King's College London, London, United Kingdom, 3Department of Congenital Heart Disease, Evelina London Children's Hospital, London, United Kingdom
Motion is a key limiting factor in fetal cardiac MRI as the small, rapidly beating heart is subject to various periodic and spontaneous motions. Highly accelerated real-time imaging with high temporal resolution was used to obtain serial ‘snapshots’ of the fetal heart and surrounding anatomy that could be motion-corrected and reassembled, combining several cardiac cycles into a single heartbeat. A super-resolution reconstruction was applied to increase the visibility of dynamic anatomical features in the densely sampled data. The resulting cine images provide a clear depiction of dynamic cardiac features.

7 A Golden-Angle Acquisition Coupled with k-t Sparse SENSE Reconstruction for Fetal Self Retro-Gated Cine Cardiac MRI: an In Vivo Feasibility Study
Jerome Chaptinel1, Yvan Mivelaz2, Jerome Yerly1,3, Leonor Alamo1, Milan Prsa2, Yvan Vial4, François Gudinchet1, Gregoire Berchier1, Jean-Baptiste Ledoux1, and Matthias Stuber1,3
1Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Department of Pediatrics, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 4Department of Gynecology-Obstetrics, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
Fetal cardiac cine MRI is challenging due to the lack of an ECG trigger signal, fetal motion, and the need for both a high spatial and temporal resolution. To overcome these hurdles, we have developed and tested a new acquisition-reconstruction paradigm: data collection was performed with a continuous radial golden-angle acquisition and cine images were reconstructed with a k-t sparse SENSE algorithm. A cardiac gating signal was extracted from the images themselves and supported self retro-gated reconstructions in which motion-corrupted data were excluded. Fetal self retro-gated cardiac cine images with high temporal and spatial resolution were successfully obtained in pregnant patients.

8 Accurate T1 mapping in patients with Pulmonary Hypertension and age matched volunteers using synthetic image based registration
Laura Claire Saunders1, Neil J Stewart1, Charlotte Hammerton1, David Capener1, Valentina O Puntmann2, David G Kiely3, Martin J Graves4, Andy Swift1, and Jim M Wild1
1Academic Unit of Radiology, The University of Sheffield, Sheffield, United Kingdom, 2Department of Cardiovascular Imaging, Kings College London, London, United Kingdom, 3The University of Sheffield, Sheffield, United Kingdom, 4University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Patients with suspected pulmonary hypertension (n=94) and healthy volunteers (n=26) underwent T1 mapping of the right ventricle with a Modified Look Locker inversion recovery (MOLLI) sequence at 1.5T. MOLLI images were registered using pairwise registration to synthetic images produced using a simplified inversion recovery model to correct cardiac or respiratory motion. 89% of patients and 100% of healthy volunteers were successfully registered, with mean T1s of 1.00±0.10s and 0.97±0.06s (septal), 1.05±0.11s and 0.97±0.06s (right ventricular insertion point) and 1.02±0.11s and 1.04±0.13s (right ventricular free wall) respectively.

9 Towards a quantitative MRI-based measure of disease burden in patients with atrial fibrillation
Maurce Pradella1, Sven Knecht2, Michael Kühne2, Aline Mühl2, Tobias Reichlin2, Gian Voellmin2, David Conen2, Jens Bremerich1, Stefan Osswald2, Christian Sticherling2, and Bram Stieltjes1
1Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2Department of Cardiology, University of Basel Hospital, Basel, Switzerland
Atrial fibrillation (AF) is a common disease and associated with myocardial infarction, stroke and dementia. We propose a new approach based on the sphericity of fitted ellipsoids in left atriums of patients with AF. Our results show a strong correlation between sphericity of these ellipsoids and burden of disease and may serve as an objective surrogate parameter in the future.

10 Joint Processing of Highly Accelerated Multi-Directional PC-MRI Data Using ReVEAL
Adam Rich1, Lee C. Potter1, Ning Jin2, Juliana Serafim da Silveira3, Orlando P. Simonetti3, and Rizwan Ahmad3
1Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, 2Siemens Medical Solutions, The Ohio State University, Columbus, OH, United States, 3Dorthy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States
Phase-contrast magnetic resonance is a powerful tool for study of cardiac flow, but clinical application is limited to planar imaging of one velocity component. This abstract demonstrates three-directional flow imaging using a single breath-hold acquisition.  Imaging is accomplished by jointly processing all encodings and frames; Bayesian reconstruction leverages image structure via both wavelet compression and statistical relations among velocity encoded images. Digital phantom results show accurate estimation of stroke volume and peak velocity, with significant reductions in bias and variance, as well as over 30% increase in Pearson correlation coefficient, compared to L1-SENSE. In vivo results demonstrate repeatable flow estimation.

11 A new hybrid approach for quantitative multi-slice myocardial DCE perfusion
Edward DiBella1, Devavrat Likhite1, Ganesh Adluru1, Chris Welsh1, and Brent Wilson1
1University of Utah, Salt Lake City, UT, United States
Here we propose a unique perfusion acquisition that uses one saturation pulse per heartbeat. This combined with simultaneous multi-slice (SMS) methods allows for acquiring the same set of slices continuously through the cardiac cycle. This has a number of advantages including the ability to retrospectively reconstruct an accurate arterial input function (AIF) and optimized systolic/diastolic frames, or other portions of the cardiac cycle. The approach proposed here acquires both k-space rays that reflect the influence of the saturation pulse and other rays that reflect the steady-state GRE contrast, and thus is termed the “hybrid” method.  Preliminary quantitative results including comparisons to more standard methods in two subjects show the promise of this SMS approach.

12 Added Value of Phase-Contrast MRI based Turbulent Kinetic Energy Quantification for the Assessment of Aortic Stenosis Severity - Permission Withheld
Alexander Gotschy1,2, Christian Binter1, Simon H Sündermann3, Michelle Frank2, Felix C Tanner2, Robert Manka2, and Sebastian Kozerke1
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3Division of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
Aortic stenosis (AS) is the most prevalent valvular heart disease. Risk stratification and the decision for valve replacement are mostly based on echocardiography and symptomaticity. This work investigates the additional value of quantifying Turbulent Kinetic Energy (TKE) for the assessment of AS severity beyond echocardiographic measures. TKE was confirmed to be significantly elevated in patients with AS compared to controls. While TKE showed only weak correlation with the echocardiographic Mean Pressure Gradient, TKE allowed to discriminate the impact of bicuspid aortic valves and aortic dilatation on energy loss in AS patients; effects which are not assessable by standard echocardiographic measures.

13 In-Vivo Quantification of Myocardial Stiffness in Heart Failure with Preserved Ejection Fraction Using Magnetic Resonance Elastography: Assessment in a Porcine Model
Ria Mazumder1,2, Samuel Schroeder2,3, Xiaokui Mo4, Bradley D Clymer5, Richard D White2,6, and Arunark Kolipaka2,6
1Department of Electrical and Computer Enginerring, The Ohio State University, Columbus, OH, United States, 2Department of Radiology, The Ohio State University, Columbus, OH, United States,3Department of Mechanical Engineering, The Ohio State University, Columbus, OH, United States, 4Department of Biomedical Informatics, The Ohio State University, Columbus, OH, United States,5Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, 6Department of Internal Medicine-Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, United States
Left ventricular (LV) myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction (HFpEF) and hence has the potential to be used as a diagnostic tool. Current clinical techniques to estimate LV MS are invasive in nature and provides global stiffness measurements. Therefore, in this study, we implement cardiac magnetic resonance to investigate temporal alteration in LV MS over a two month period of disease progression in a porcine model induced with HFpEF. The alteration in LV MS is compared against change in mean LV pressure, LV thickness, circumferential strain and MRI relaxometry parameters.

14 Free breathing self-gated PC-MRI  with Pseudo Random sampled kt-Sparse-Sense
Volker Herold1, Patrick Winter1, Philipp Mörchel2, Fabian Gutjahr1, and Peter Michael Jakob1
1Department of Experimental Physics 5, University of Wuerzburg, Wuerzburg, Germany, 2Research Center for Magnetic Resonance Bavaria e.V., Wuerzburg, Germany
Phase-Contrast (PC) cine MRI is an established method for the assessment of blood flow and tissue motion patterns in cardiovascular MRI. In this paper we presented a highly accelerated self-gated PC-MRI-sequence based on free breathing random sampled data acquisition. Data acquired during respiratory motion as well as any other source of undesirable motion can be excluded from the post-processing. Moreover ECG-signal acquisition which is prone to distortions especially at higher field strength can be avoided. The high flexibility of data processing would also allow the correction of unstable heart rate during the measurement. 

15 End-systolic Myocardial Perfusion MRI Using a Hybrid 2D/3D Steady-State Acquisition Scheme: Towards Reliable Detection of Subendocardial Ischemia in Coronary Microvascular Dysfunction
Behzad Sharif1, Rohan Dharmakumar1, Daniel Berman2, Debiao Li1, and Noel Bairey Merz2
1Biomedical Imaging Research Institute, Dept of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
A significant portion of patients with ischemic heart disease suffer from coronary microvascular dysfunction. Despite intense interest and several recent advancements, reliable diagnosis of coronary microvascular dysfunction on the basis of stress first-pass perfusion (FPP) cardiac MRI is an ongoing challenge. We hypothesized that high-resolution systolic FPP imaging can detect diffuse vasodilator-induced subendocardial defects and transmural perfusion gradients consistent with microvascular dysfunction in a swine model of diet-induced diabetes with no obstructive disease. To this end, we developed, optimized, and tested a new high-resolution FPP method with hybrid 2D/3D excitation capable of imaging all myocardial slices at the end-systolic phase.

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