ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Sunrise Educational Session: CEST Imaging: Techniques & Challenges

Skill Level: Advanced

Organizers: Jenny T. Bencardino, M.D., Eric Y. Chang, M.D., Christine Chung, M.D., Ravinder R. Regatte, Ph.D., Philip Robinson, M.D. & Siegfried Trattnig, M.D.

Wednesday 11 May 2016

This one-hour sunrise session will cover the added value of assessment of cartilage, disc and muscle using Chemical Exchange Saturation Transfer (CEST).

Target Audience
Radiologists and Physicists.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Describe current protocols and technical challenges in CEST imaging applied to the MSK system;
  • Recognize the added value of CEST Imaging in evaluation of clinical and research patients; and
  • Describe the current challenges for implementation of CEST method for clinical translation.

Moderator: Ravinder Reddy
CEST Imaging Techniques & Challenges
Gil Navon1
1School of Chemistry, Tel Aviv University, Tel Aviv, Israel
The following applications of CEST-MRI for endogenous and exogenous diamagnetic agents will be reviewed: glycoCEST, gagCEST, gluCEST, APT, crCEST, miCEST, sialoCEST and mucCEST, glucoCEST and acidoCEST.

MSK Applications (Cartilage, Disc , Muscle)
Benjamin Schmitt1
1Magnetic Resonance, Siemens Healthcare
The two main applications for CEST in MSK are discussed in this session. This will include an introduction to glycosaminoglycan-dependent chemical exchange saturation transfer (gagCEST) imaging as well as CEST imaging with endogenous contrast in skeletal muscle. GagCEST imaging has been very successfully used to assess loss of proteoglycans in cartilage tissue and intervertebral discs. The technical challenges of gagCEST, such as the effect of field strength on signal will be explained, and experimental considerations will be discussed. Applications in skeletal muscle include CEST imaging of lactate and creatine. Both metabolites are important markers of energy metabolism and can be detected with high spatial and temporal resolution using CEST.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.