ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Sunrise Educational Session: Demyelinating Diseases

Skill Level: Intermediate to Advanced

Organizers: Andrew Alexander, Ph.D. & Jennifer A McNab, Ph.D.

Thursday 12 May 2016

This session will provide an overview of white matter imaging changes with neuropathology including demyelination, and axonal degeneration.

Target Audience
Scientists and clinicians seeking to understand how MRI measures change with demyelinating diseases.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Describe how neuroimaging results show changes in demyelinating diseases;
  • Recognize neuroimaging biomarkers of demyelinating diseases; and
  • Design an MRI protocol to diagnose demyelinating disease.

Moderators: Julien Cohen-Adad, Claudia Wheeler-Kingshott
MRI of Brain Demyelination
Roland G Henry1
1Neurology, University of California, San Francisco CA, San Francisco, CA, United States
Myelin is essential for normal neuronal function but the impact of demyelination depends on the other factors associated with the pathology including impact on oligodendrocytes, astrocytes, and immune response. The use of MRI in the study of neurological disorders includes three major categories: Prognostic value and patient management, Trial outcome markers to detect response to treatment, and studies to gain insight into disease mechanisms. The utility of MRI techniques to these ends depend on the specificity of the technique for myelin, the specificity for overall positive responses, sensitivity to pathological changes and improvements, and multicenter and clinical feasibility.

MRI of Spinal Cord Demyelination
Daniel S. Reich1
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
The spinal cord is heavily affected in multiple sclerosis and several other demyelinating conditions. This talk will describe MRI findings in spinal cord demyelinating diseases; challenges in successfully imaging the spinal cord, as well as ways of overcoming those challenges; and recent improvements in spinal cord structural MRI as applied to multiple sclerosis.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.