ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Sunrise Educational Session: Hyperpolarisation & MR Applications

Skill Level: Intermediate to Advanced

Organizers: Thomas K. F. Foo, Ph.D. & N. Jon Shah, Ph.D.

Tuesday 10 May 2016

This course is designed for physicists and engineers to provide an introduction to new or emerging MR methods and applications that are gaining interest. The session provides a description of the underlying physics principles, image acquisition and reconstruction methods, pitfalls and challenges associated with hyperpolarized MR imaging. The clinical potential of this new MR imaging method will be discussed.

Target Audience
Those with an interest in: 1) understanding principles of hyperpolarization, including the operation of commercially available dynamic nuclear polarization methods and alternative hyperpolarization methods, 2) understanding the optimal acquisition methods for rapid data acquisition of short-lived hyperpolarized nuclei, including image reconstruction methods, and 3) understanding the potential clinical applications and implementation of hyperpolarized MRI in a clinical setting.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Understand and implement the optimum acquisition methods for rapid image acquisition for hyperpolarized nuclei with different chemical shift species;
  • Better design experiments that utilize hyperpolaried MR for specific applications, with improved understanding of the limitations and pitfalls associated with hyperpolarized MRI; and
  • Better appreciate the added functional information and the clinical impact of metabolic imaging that is enabled by hyperpolarized MRI, and how this can be used in a clinical setting.

Moderators: Sean Fain, Philip Lee
Hyperpolarisation - Description, Overview & Method
Rolf F Schulte1
1GE Global Research, Munich, Germany
Metabolic imaging using hyperpolarised substances is a relatively new research field looking at metabolic processes in the body minimally invasive. In this educational talk, the basic principles of dissolution dynamic nuclear polarisation are introduced. The most commonly used substance is [1-13C]pyruvate, which gets taken up into the cells and converted enzymatically into lactate, alanine and bicarbonate. Five dimensional MR encoding is required to capture spectral, temporal and 3D spatial information.

Hyperpolarisation - Clinical Potential & Relevance
Ferdia Aidan Gallagher1
1Radiology, University of Cambridge, Cambridge, United Kingdom
Hyperpolarized carbon-13 MRI is a new method for imaging tissue metabolism. [1-13C]Pyruvate is the leading probe used with the technique and is converted into lactate under the action of lactate dehydrogenase (LDH). Hyperpolarized carbon imaging has recently been translated into humans and there are a number of sites now undertaking clinical studies. Potential applications may be found in oncology, cardiology and neurology; for example, it has the potential to aid diagnosis, identify disease heterogeneity, predict disease outcome, help target biopsies and determine treatment response non-invasively.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.