ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Combined Educational & Scientific Session: Rapid Three-Dimensional (3D) MSK Imaging

Skill Level: Intermediate to Advanced

Organizers: Jenny T. Bencardino, M.D., Eric Y. Chang, M.D., Christine Chung, M.D., Ravinder R. Regatte, Ph.D., Philip Robinson, M.D. & Siegfried Trattnig, M.D.

Thursday 12 May 2016

This session will address recent emerging rapid 3D-MSK imaging including steady state, MR fingerprinting and compressed sensing strategies. Lecturers will discuss basic physical principles, challenges and potential clinical applications.

Target Audience
This course is directed to biomedical researchers, physician scientists and  graduate students  interested in applying new emerging rapid 3D-MR imaging techniques specific to musculoskeletal tissues,  potential  clinical applications and potential impact.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Review the  Rapid 3D-steady state imaging methods for MSK imaging;
  • Identify the role new emerging methods of MR fingerprinting and compressed methods for MSK imaging; and
  • Describe the potential clinical applications of 3D-MSK imaging.

Moderators: Xiaojuan Li, Riccardo Lattanzi
Rapid 3D-MSK Imaging: Techniques & Challenges
Martijn Cloos1
1Bernard and Irene Schwartz Center for Biomedical Imaging, and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States
In this talk we will discuss the pros and cons of 3D MSK imaging from a technical prospective. Using select examples, we will explore how the transition from 2D (slice-selective) to 3D (volumetric) imaging influences the contrast, resolution and acquisition time. The presentation will start with the fundamental principles of 3D imaging from which we will buildup to the latest developments, such as compressed sensing and magnetic resonance fingerprinting.

Clinical Applications of 3D-MSK Imaging
Richard Kijowski
This lecture will review the clinical applications of three-dimensional sequences FSE sequences in musculoskeletal MR imaging.

Fast single sequence comprehensive 4D pediatric knee MRI with T2 Shuffling
Shanshan Bao1, Jonathan I. Tamir2, Umar Tariq3, Martin Uecker4, Peng Lai5, Weitian Chen5, Michael Lustig2, and Shreyas S. Vasanawala1
1Radiology, Stanford University, Stanford, CA, United States, 2University of California, Berkeley, Berkeley, CA, United States, 3Geisinger Medical Center, Danville, PA, United States, 4University Medical Center Göttingen, Göttingen, Germany, 5GE Healthcare, Menlo Park, CA, United States
Clinical application of volumetric joint MR imaging has been hampered by blurring due to T2 decay. A redesigned volumetric fast spin-echo acquisition technique termed T2 shuffling corrects for T2 decay and yields effectively a four-dimensional reconstruction with varying degrees of T2 weighting. Our work assesses the clinical application of T2 shuffling for pediatric knee MRI. Our results show that T2 shuffling has the potential to suffice as a single sequence MR examination. This is especially relevant for pediatric imaging where streamlined protocols greatly improve clinical operations and patient experience.

Rapid Three-Dimensional Fast Spin-Echo Knee Imaging Using Compressed Sensing
Fang Liu1, Humberto Rosas1, James Holmes2, Kevin King2, Rob Peters2, and Richard Kijowski1
1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Applied Science Laboratory, GE Healthcare, Waukesha, WI, United States
A Cube 3D-FSE sequence was performed with and without compressed sensing (CS) twice on the knees of 10 asymptomatic volunteers to assess signal-to-noise- ratio (SNR) and once on the knees of 25 symptomatic patients to assess diagnostic performance for detecting knee joint pathology.  CS k-space acceleration provided a 30% reduction in scan time without a corresponding decrease in SNR.  The use of CS resulted in mild increased image blurring which did not influence diagnostic performance with near perfect to perfect agreement between Cube and Cube-CS for detecting knee joint pathology. 

A Variable-TE Stack-of-Spirals Sequence for 3D UTE Imaging
Samuel Fielden1, John Mugler2, Wilson Miller2, Alto Stemmer3, Josef Pfeuffer3, Berthold Kiefer3, and Craig Meyer1,2
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States, 3Application Development, Siemens Healthcare, Erlangen, Germany
While 3D radial-based methods have become established in recent years for ultrashort-echo-time (UTE) imaging, these acquisitions are generally slow due to the inefficiency of radial k-space trajectories. The purpose of this work was to implement a fast UTE acquisition based on an optimized 3D stack-of-spirals acquisition and to perform a proof-of-concept evaluation of the method for bone imaging of the skull and cartilage imaging of the knee.

High spatial and temporal resolution DCE-MRI of intervertebral disc endplates using GRAPPA accelerated 3D-Linogram acquisition
L. Tugan Muftuler1,2, Ali Ersoz3, and Volkan Emre Arpinar1
1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 2Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI, United States, 3Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States
It is suggested that disruption of nutrient delivery through the intervertebral disc endplates could lead to physiological and morphological changes in the discs. Our earlier DCE-MRI studies demonstrated major changes in endplate regions. However, we had to sacrifice temporal resolution to obtain high spatial resolution to image the thin endplates. Higher temporal resolution is needed for quantitative analysis of tracer kinetics. Therefore, we developed and tested 3D-Linogram acquisition technique that allowed higher temporal resolution and reduced motion artifacts. Tofts’ tracer kinetic model was implemented and Ktrans values from vertebral endplates were estimated.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.