ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Educational Session: Advanced Tumour Tutorial

Skill Level: Intermediate

Organizers: Jeffrey Neil, M.D., Ph.D. & Howard Rowley, M.D.

Tuesday 10 May 2016

This course will discuss MRI techniques for diagnosis, treatment guidance and monitoring of brain tumors at the pre-operative, intra-operative and post-treatment phases.

Target Audience
Physicists and clinicians involved in the evaluation of brain tumors.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Describe the MR changes identified with different types of tumors;
  • Illustrate the importance of these changes in the broader healthcare environment; and
  • Demonstrate the additional value of multiparametric MR in brain tumor imaging.

Moderators: Howard Rowley, Steven Stufflebeam
Advanced Tumor Imaging: Pre-operative Mapping
Timothy Roberts1
1Childrens Hospital of Philadelphia / U Penn
Advanced Tumor Imaging: Preoperative Planning

Advanced Tumor Tutorial: Intra-Operative Imaging
Alberto Bizzi
Advanced Tumor Tutorial: Post-Treatment Response Assessment
Benjamin M Ellingson1
1Radiology, University of California Los Angeles, Los Angeles, CA, United States
The current lecture will discuss the current standard of care in glioblastoma and malignant glioma as well as new therapies and how they are integrated and may change into this therapeutic landscape. We will then introduce a brief history of response assessment from the WHO and Levin Criteria through Macdonald and classical response assessment in neuro-oncology (RANO) criteria. We will briefly discuss new RANO initiatives including RANO for low grade gliomas, RANO for immunotherapies (iRANO), and updates on classical RANO criteria being developed for the new GBM AGILE global adaptive trial. In addition to classic response assessment we will discuss new perfusion MR approaches including quantification of hypervascular tumor volume by comparison to a large-scale radiographic atlas, new leakage correction algorithms for improved quantification of cerebral blood volume, and the use of new multi-echo perfusion techniques including vascular size imaging (VSI) to characterize changes malignant glioma vasculature during therapy. Lastly we will discuss promising new clinical imaging techniques including pH- and hypoxia-weighted multi-echo amine chemical exchange saturation transfer echoplanar imaging (CEST EPI) of malignant gliomas under a variety of therapeutic conditions in both human and preclinical models.

Adjournment & Meet the Teachers


The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.