ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Educational Session: Quantitative Imaging of Cancer

Skill Level: Intermediate to Advanced

Organizers: Linda Moy, M.D. & Valeria Panebianco, M.D.

Wednesday 11 May 2016

The clinical importance of using MR techniques for monitoring tumor response to anticancer therapy is rapidly growing. Recent advances in the design of therapeutic agents and methods have made it possible to combine cancer therapy with MR imaging as well as other imaging modalities to enable imaging responses.

Target Audience
Clinicians and M.D. & Ph.D. researchers who will benefit from tool and techniques for noninvasively measuring tumor response to therapy and combining therapy with MR imaging for theranostic MRI.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Assess the advantages and disadvantages of different MR techniques for measuring tumor response to therapy;
  • Evaluate the added value of different MR approaches to monitor lung, rectal, gynocological and pediatric brain tumours; and
  • Understand the options for imaging tumours and the differences in protocols associated with different anatomical tumour locations.

Moderators: Hua Guo, Valeria Panebianco
Quantitative Imaging of Metastatic Kidney Cancer
Laure Fournier1, Alexandre Bellucci1, Yann Vano2, Daniel Balvay3, Stephane Oudard2, and Charles Andre Cuenod1
1Radiology, Hopital Europeen Georges Pompidou, Paris, France, 2Medical Oncology, Hopital Europeen Georges Pompidou, Paris, France, 3Team 2, INSERM U470, Paris, France
Current treatment of metastatic renal cell carcinoma relies on anti-angiogenic drugs, used successively, to prolong patient survival. Functional imaging accompanied anti-angiogenic drug development by helping elicit biological mechanisms, and developing biomarkers of tumour response. Remaining challenges include understanding drug escape mechanisms and toxicities of anti-angiogenic drugs, as well as accompanying clinical trials using new immunotherapies.

MR Imaging biomarkers in assessing response to therapy of rectal cancer
Andrea Laghi
Neoadjuvant chemo-radiotherapy (CRT) has become the standard treatment for locally advanced rectal cancer. In order to define the best therapeutic strategy following CRT, either extended surgery (Total Mesorectal Excision, TME), low-invasive transanal endoscopic microsurgery (TEM) or wait-and-watch strategy, an accurate assessment of tumor response to therapy is mandatory. Currently, MR is the modality of choice in assessing response to therapy. However, conventional morphological imaging methods are not accurate enough, particularly in evaluating complete response. Quantitative imaging biomarkers are under evaluation, with some of them showing preliminary interesting results, namely diffusion-weighted imaging, texture analysis and perfusion MR. 

A Practical Approach to MRI of Female Pelvic Masses
Katja Pinker-Domenig1
1Dept. of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
Female pelvic masses comprise a broad spectrum of benign and malignant tumors and conditions that often pose a diagnostic challenge. A systematic evaluation that integrates the clinical and surgical history and multiparametric magnetic resonance imaging (MRI) to identify the anatomic origin, morphologic features, and tissue composition of a female pelvic mass helps to establish a short, meaningful differential diagnosis or, often, even a definitive diagnosis. This presentation aims to review the standard female pelvic based on the indications and provide a practical approach to MRI of female pelvic masses.

Pediatric Brain
Benjamin Cohen1
1NYU Langone Medical Center
In conjunction with conventional sequences, advanced/quantitative MR imaging techniques can refine differential diagnostic considerations, suggest tumor grade, propose targets for stereotactic biopsy, and monitor response to therapy for pediatric brain neoplasms.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.