ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Weekend Educational Course: PET-MRI: Devices, Radiotracers & Applications

Skill Level: Intermediate

Organizers: Andrei H. Iagaru, M.D., Ryan Niederkohr, M.D., N. Jon Shah, Ph.D. & Greg Zaharchuk, M.D., Ph.D.

Saturday 07 May 2016

This course will cover the topic of PET/MRI, ranging from technical development to clinical applications. Technical development will include understanding basic MR approaches to attenuation correct and motion correction. A session will discuss radiotracers from chemistry to new agents to regulatory issues confronting the new investigator. Finally, we will provide a broad overview of clinical and research applications within the body and in the brain.

Target Audience
MRI scientists and clinicians interested in combined PET-MRI. Nuclear Medicine physicians and researchers interested in learning more about combined PET-MRI.

Educational Objectives
Upon completion of this course, participants should be able to:

  • To learn basics of PET/MRI scanner design and attenuation correction algorithms;
  • To understand how radiotracers are made and novel organ- and function-specific probes; and
  • To develop time-efficient PET/MRI workflow for various clinical applications.


Moderators: N.Jon Shah, Greg Zaharchuk

      Physics & Technology Issues in PET/MRI  
PET/MRI Scanner Overview
Jae Sung Lee1
1Department of Nuclear Medicine, Seoul National University, Seoul, Korea, Republic of
Attenuation & Motion Correction Strategies for PET Using PET/MRI
Youngho Seo1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco
Attenuation correction (AC) for PET reconstruction using PET/MRI is not trivial.  MRI-based segmentation, atlas registration, and time-of-flight derived attenuation coefficients are most commonly applied and studied approaches for AC. Motion management of PET reconstruction, aided by the temporal resolution of MR-based signal, is promising, but still requires extensive investigation and robust method development.

Time-of-Flight: Do We Need It in PET/MRI?
Christoph Lerche1
1Institute for Neuroscience and Medicine, Forschungszentrum Jülich GmbH, Jülich, Germany
The aim of this presentation is to introduce the participant into Time-of-Flight (ToF) Positron Emission Tomography. General concepts of ToF-PET, fundamental limits and most important characteristics of the key components scintillator and photo detector will be discussed. The correlation between timing resolution and image SNR, which is the main benefit of the timing measurement, will be introduced by means of examples from real patient examinations and simulations. Special emphasis will be put on completely new imaging application enabled by ToF-PET and on the potential of ToF-PET for simultaneous MR/PET imaging.

Future Directions in PET/MRI - Permission Withheld
Craig Levin1
1Radiology, Stanford University, Stanford, CA, United States
Break & Meet the Teachers
      PET Radiopharmacy  
PET Radiopharmacy 101
Frederick T. Chin1
1Stanford University
Radiation Safety & Procedures - Permission Withheld
S. Somanesan1
1Singapore General Hospital
Knowing how to protect oneself from radiation is an important aspect in the healthcare imaging workplace. Besides self-protection, knowledge about radiation can also aid healthcare professionals safeguard the health of their patients from excessive radiation. This talk serves to provide participants a basic understanding of ionizing radiation, X-rays  and radiobiology, as well as unravel the mystery of minimizing radiation doses in medical imaging.

Beyond FDG: New Tracers
Dale L Bailey1
1University of Sydney, Sydney, Australia
PET/MRI has the potential to offer not just structure/function characterisation, but structure/function/tissue characterisation in a way that conventional CT combined with PET cannot provide. This talk will explore options beyond conventional FDG whole body PET/CT for detailed characterisation of the individual patient and their disease.

Regulatory Issues for Radiotracers around the World
David Dick1
1Radiology, University of Iowa
This presentation will highlight the differences between PET radiopharmaceuticals and MRI contrast agents with respect to regulatory approval in order to educate those working with PET/MRI on the regulatory framework under which PET radiopharmaceuticals can be administered.

Lunch & Meet the Teachers
      Clinical Hybrid Imaging Throughout the Body  
Interpreting FDG PET images - a Crash Course
Eric M. Rohren1
1Baylor College of Medicine
Clinical PET/MRI: Workflow Considerations
Marius Mayerhoefer1 and Matthias Eiber2
1Medical University of Vienna, Vienna, Austria, 2Technical University of Munich, Munich, Germany
Oncological PET/MRI: Where Will it Replace PET/CT?
Thomas Hope1
1University of California, San Francisco
Cardiac PET/MRI
Osman Ratib
The development of hybrid PET/MRI imaging devices provides new perspectives in cardiovascular imaging. While these two imaging modalities (PET and MRI) have gained  well-established diagnostic value in clinical practice, the ability to acquire both modalities in a single session opens new perspectives in workflow and in assessment and quantitative evaluation of cardiovascular diseases. The development of new PET tracer will certainly add to the value of clinical applications of hybrid PET/MRI in the futur 

Pediatric PET/MRI
Jonathan McConathy
Break & Meet the Teachers
      Neuroimaging with PET/MRI  
Role of PET/MRI in Brain Tumors
Fernando Emilio Boada1
1Radiology, New York University, New York, NY, United States
This presentation discusses the synergies that make MRI/PET a unique hybrid technology that could be used effectively to improve the diagnostic and prognostic information from each of its component modalities.

Brain Perfusion & Permeability Imaging
Tadashi Nariai1
1Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan
Educational Lecture to discuss on the clinical usefulness of combined use of PET and physiological imaging with MRI. Focus is set on chronic occlusive cerebrovascular diseases and malignant brain tumor.

Functional Imaging with PET/MRI
Joseph Mandeville
Among many potential applications of simultaneous PET and fMRI, this talk focuses on paradigms of function (fMRI) versus occupancy (PET) and combinations that investigate flow-metabolism coupling or oxygen versus glucose utilization. PET/fMRI can help clarifying aspects of receptor-based imaging using either drug or tasks that elevate neurotransmitter levels. The combined information has the potential to form new biomarkers with clinical utility. Metabolic imaging using PET in conjunction with fMRI measurements of CBF and CMRO2 can be done simultaneously within a single imaging session. This talk focuses on PET capabilities and possibilities for combining PET and fMRI information.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.