ISMRM 24th Annual Meeting & Exhibition 07-13 May 2016 Singapore

Weekend Educational Course: Advanced fMRI: Techniques & Applications

Skill Level: Advanced

Organizers: Jay J. Pillai, M.D. & Jonathan R. Polimeni, Ph.D.

Saturday 07 May 2016

This session will cover advanced topics in fMRI acquisition and analysis including data-driven analysis approaches, advanced functional connectivity, and emerging applications of Simultaneous Multi-Slice EPI.

Target Audience
Cognitive neuroscientists, neuroradiologists, clinicians and imaging scientists who currently utilize fMRI and for MR physicists and engineers developing new fMRI methodologies. This course assumes basic knowledge of fMRI and a working knowledge of neuroscience, MR data acquisition, and basic analysis methods.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Perform data driven analyses of fMRI data;
  • Explain the static and dynamic factors that give rise to observed functional connectivity patterns;
  • Employ network analytic approaches to functional connectivity data;
  • Recognize artifacts in fMRI time-series data caused by subject motion;
  • Evaluate the benefits of calibrated BOLD techniques for measuring brain activity; and
  • Apply rapid acquisition techniques to fMRI studies and appraise the benefits of MultiBand EPI.

Moderator: Jay Pillai, Jonathan Polimeni
Dynamic Functional Connectivity
Gary H. Glover1
1Stanford University
Dynamic functional connectivity (dFC) uses region-of-interest or data driven methods to elucidate temporally-varying changes in resting-state brain networks. Challenges are the lack of a gold standard for dFC, the difficulty in discriminating signal from non-neurally generated BOLD fluctuations, and the tradeoffs between temporal resolution of the neural dynamics and the statistical significance of the resulting networks. This talk will describe the methods and pitfalls to be avoided in applying these techniques, as well as results that correlate with independently acquired measures of behavior and psychometrics.

Network Analysis - Permission Withheld
Martijn van den Heuvel
Figure 1. Figure illustrates common graph metrics in connectomics (described in the text). 

Clinical Applications of Functional Connectivity
Steven Stufflebeam
Break & Meet the Teachers
Calibrated BOLD fMRI
Claudine Gauthier1
1Concordia University
Calibrated fMRI techniques are used to extract the oxidative metabolism component from the BOLD signal measured in response to a task. Oxidative metabolism is isolated by first estimating the vascular component of the BOLD response through a calibration manipulation and a biophysical model. Various calibration methods have been proposed using mild hypercapnia, hyperoxia, or a combination of the two. Extensions of these techniques now allow measurement of baseline oxidative metabolism. This course will allow fMRI users to learn about calibrated fMRI and how it can be used to obtain quantitative measures of brain activity and resting metabolism.

Multi-Band EPI Applications to fMRI - Permission Withheld
Prantik Kundu1
1Radiology and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Multi-band EPI is becoming a standard acquisition scheme for functional MRI. Here we will evaluate how multi-band acceleration benefits fMRI. We will address how accelerating to increase temporal resolution leads to de-aliasing of nuisance physiological signals and supports resolving complex BOLD activity. In accelerating to increase spatial resolution, we will consider temporal signal-to-noise ratio losses due to high resolution, and how multi-band compensates through imaging more volumes. We will assess multi-band multi-echo fMRI, which incorporates T2* relaxometric techniques for susceptibility artifact compensation and thermal noise reduction. Lastly, we will review the multi-band EPI configuration of the Human Connectome Project and clinical translatability of its multi-band approach.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.