Weekend Educational Course: Diffusion MRI Applied
Skill Level: Basic to Intermediate
Organizers: Daniel C. Alexander, Ph.D., Chunlei Liu, Ph.D. & Stephan E. Maier, M.D., Ph.D.
Saturday 07 May 2016
This course will explore selected clinical and research applications of diffusion MRI in brain and body. The first five lectures will focus on applications in neurodevelopment, aging, stroke, psychiatric disorders and forensic medicine. The next four lectures will focus on applications in tumor imaging and the musculoskeletal system. Ample time will be provided for discussion with the speakers.
This course is designed for basic scientists, clinicians and technologists, who would like to learn more about the broad applications of diffusion MRI both in brain and body.
Upon completion of this course, participants should be able to:
- Describe the broad range of clinical and research applications of diffusion MRI;
- Explain the basic findings in the selected applications;
- Utilize the analysis techniques for corresponding applications; and
- Understand the limitations and challenges.
Diffusion MRI of
Diffusion MRI of Aging & Neurodegeneration - Permission Withheld
1Radiology, Nihon University School of
Medicine, Tokyo, Japan
Diffusion MRI can provide not only parametric and but
also directional information, which quantify white
matter fiber integrity and cellular density as well as
neural connectivity between nodes in the brain. In this
talk, we will give the audience how to preprocess imaging
data, for example, distortion and bias correction.
Then, we will show several results for parametric
analyses and structural connectivity measured by
diffusion MRI in normal aging and neurodegenerative
Diffusion MRI of Stroke
Stroke is the second leading cause of death world-wide.
Diffusion-weighted MRI (DWI) is very sensitive to early
acute ischemic injury, with mean diffusivity reduced in
the hyperacute stage, but elevated in the chronic
stages. In addition, DWI can potentially be combined
with other MRI sequences to stage extent of ischemic
injury and identify potentially salvageable tissue.
Diffusion-tensor MRI and high angular resolution
diffusion MRI techniques can be used to evaluate
ultrastructural injury post-stroke. DWI has been shown
to critical for improving the diagnosis, prognosis and
management of acute ischemic stroke patients and for
monitoring post-stroke recovery.
Diffusion MRI of Psychiatric Disorders
Kelvin O. Lim1,2
1Psychiatry, University of Minnesota,
Minneapolis, MN, United States, 2Minneapolis
VA Health Care System, Minneapolis, MN, United States
Diffusion MRI has proven to be a very popular brain
imaging technique for the study of psychiatric
disorders. In schizophrenia alone, there are 570
publications that use diffusion tensor imaging.
Diffusion MRI data has been used in many ways
including: assessment of white matter integrity, tractography
and structural connectivity analyses. Many different
analytic approaches have been developed. Like other MR
modalities, diffusion MRI is also subject to artifacts
from multiple sources which can result in erroneous
values. Diffusion models, other than the tensor model,
are beginning to become popular as fast imaging
techniques make them more feasible for clinical
Diffusion MRI in Forensic Medicine
1Institute for Forensic and Traffic Medicine,
Educational lecture on Diffusion MR Imaging in forensic
medicine and research.
Break & Meet the Teachers
Characteristics of Tumors
Diffusion MRI of Brain Tumors
1Neurosurgery, Hiroshima University Hospital,
The presentation will provide the diagnostic tips of
brain tumors and tumefactive lesions by using DWI and
Diffusion MRI of Tumors
Outside the Brain
Musculoskeletal Applications of Diffusion MRI - Permission Withheld
1Biomedical Engineering and Physcis, Academic
Medical Center (AMC), Amsterdam, Netherlands
In this educational contribution the use of
diffusion-tensor (DT-) MRI muscle fiber tracking for
studying muscle architectural properties will be
discussed. Topics include the importance of muscle
structure to muscle function, how muscle architecture is
typically assessed, and DT-MRI and its application to
muscle. Examples will be given of how DT-MRI data have
been used to provide new insights into muscle function,
and lastly, important future research directions will be
Adjournment & Meet the