ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Weekend Educational Course: Clinical Cancer MRI: Case-Based

Skill Level: Basic to Intermediate

Organizers: Linda Moy, M.D. & Valeria Panebianco, M.D.

Sunday 08 May 2016

MRI has a major role in a number of cancer sites. Reporting standards and guidelines have been established. Recognition of when to use MRI, how to report it and where MRI may address unmet needs are the focus of this course. This will be illustrated through case-based learning.

Target Audience
Physicians, Imaging scientists/engineers, technologists and other health professionals with a developing need for utilizing MRI applications in cancer and personalized care.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Understand guidelines and standards for MRI of multiple tumour types;
  • Recognize potential applications of new MRI technology to better diagnose and assess therapy response in cancer patients; and
  • Understand the tumour microenvironment and the potential of MRI to assess microenvironment.

      Guidelines & Reporting Standards  
      Moderators: Linda Moy, Valeria Panebianco  
MRI Interpretation of Liver Nodules in Cirrhosis — A Standardized Approach Using LI-RADS
Claude Sirlin1
1Radiology, UCSD Medical Center, San Diego, CA, United States
This case-based lecture will briefly review basic LI-RADS concepts and then illustrate the use of LI-RADS to categorize liver observations.

DWI for diagnosis of breast cancer - Permission Withheld
Naoko Mori1
1Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan
There are already several established advantages of using DWI to diagnose breast cancer. Standardization and improvement of technology should be made to expand the clinical application of DWI in the future.

Synopsis of the PI-RADS v2 Guidelines for Multiparametric Prostate Magnetic Resonance Imaging and Recommendations for Use* - Permission Withheld
Harriet Thoeny
This presentation provides a short description of PI-RADS v2. It provides discussion of some of the key differences and improvements comparedwith PI-RADS v1 and is focussed on the assessment criteria for detection and diagnosis of significant PCa on mpMRI examinations and clinical uses and limitations. 

Break & Meet the Teachers
      Addressing Clinical Needs  
      Moderators: Linda Moy, Valeria Panebianco  
Overdiagnosis & Over Treatment - Permission Withheld
Christiane Kuhl
Overdiagnosis is an important issue in oncologic radiology.  Avoiding diagnosis of disease altogether in order to avoid overdiagnosis is, however, probably not the best solution to the problem.  Choosing appropriate Treatment based on Imaging as well as proteomic and genomic Information is probably more useful. Moreover, overdiagnosis is not the most important concern of current Screening programs - rather, under-diagnosis is. MRI is probably the best method to avoid both, over- as well as underdiagnosis 

Tumour Recurrance & Pseudo-Progression in Glioma
Alberto Bizzi
Finding Cancer in the Dense Breast: Ultrasound & MRI - Permission Withheld
Nariya Cho1
1Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea, Republic of
Features of undiagnosed breast cancers on prior screening US and screening MRI of patients with breast cancers diagnosed on subsequent screening examinations will be presented.

Lunch & Meet the Teachers
      Tumour Microenvironment  
      Moderators: Utaroh Motosugi, Harriet Thoeny  
Tumour Microenvironment
Ralph Peter Mason1
1Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Historically, radiology/imaging has served to identify tumors in terms of location, size, and metastatic spread. It is increasingly recognized that tumors may exhibit very different micro environmental characteristics, which can influence therapeutic success. A new goal is precision oncology, whereby individual tumors are further characterized based on potential prognostic imagine biomarkers. Tumor hypoxia is associated with aggressive phenotypes and resistance to therapy and may be the most significant factor influencing therapy outcomes for solid tumors. Many NMR approaches are being developed and evaluated to measure tumor oxygenation. This review will consider human applications of oxygen sensitive MRI in the context of pre-clinical developments. Strengths and weaknesses in terms of temporal and spatial resolution, precision and accuracy, ease of implementation and robustness of observations will be considered. Methods may provide qualitative or quantitative insights including dynamic response to interventions.

Collagen & Stroma - Permission Withheld
Kristine Glunde, Samata Kakkad, and Zaver M. Bhujwalla
The tumor stroma, and in particular the Col1 fiber meshwork, plays an important role in cancer migration and metastasis. Novel MRI approaches such as macromolecular contrast agent based DCE MRI and DTI can be applied to noninvasively detect critical features of the Col1 fiber network in tumors.

Tumor Associated Inflammation: Biology & Imaging
Heike Elisabeth Daldrup-Link1
1Department of Radiology, Stanford University, Stanford, CA, United States
Break & Meet the Teachers
      New Horizons  
      Moderators: Utaroh Motosugi, Harriet Thoeny  
A semi-quantitative overview of tumor CEST MRI
Phillip Zhe Sun1
1Martinos Center, MGH and Harvard Medical School
Tumor CEST MRI has emerged as a molecular imaging approach to characterize complex microenvironment, including protein/peptide, glutamate, exogenous glucose and artificial reporter gene MRI. Despite their diverse names, variant CEST imaging methods provide complementary information about the underlying tumor pathophysiology and it is helpful to provide a semi-quantitative overview to understand their potential clinical applications.

Radiomics the New Buzzword
Radka Stoyanova1
1University of Miami, FL, United States
“Radiomics” refers to the extraction and analysis of large amounts of advanced quantitative imaging features from medical images using high throughput methods. In this syllabus MRI radiomics features and extraction are described; second, examples of applications of radiomics in glioblastoma multiforme (GBM) and prostate cancer are reviewed and lastly the importance of incorporating radiomics features in clinical databases is discussed. 

Interventional MRI of Cancer
Carlo Catalano
Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.