ISMRM 24th Annual Meeting & Exhibition • 07-13 May 2016 • Singapore

Weekend Educational Course: Neuro 2

Skill Level: Intermediate

Organizers: Kelvin Lim, M.D. & Toshiaki Taoka, M.D., Ph.D.

Sunday 08 May 2016

This course will explore the uses of MRI in the diagnosis and management of spine and plexus pathologies, pediatric patients, CNS infections and psychiatric disease.

Target Audience
Neuroradiologists, clinical neurospcialists and neuromaging researchers.

Educational Objectives
Upon completion of this course, participants should be able to:

  • Increase the ability to choose and interpret MR protocols and pulse sequences and relate imaging to pathology in the Spine and Plexus;
  • Increase the ability to choose and interpret MR protocols and pulse sequences and relate imaging to pediatric pathology;
  • Increase the ability to choose and interpret MR protocols and pulse sequences and relate imaging to pathology in CNS Infections; and
  • Increase the ability to choose and interpret MR protocols and pulse sequences and relate imaging to pathology in depression, addictions and PTSD.

      Spine & Plexus  
      Moderator: Alex MacKay  
Advanced Mutimodal Imaging of the Spine
Lawrence N. Tanenbaum1
1RadNet Inc
The role of diffusion weighted imaging has expanded beyond the brain to whole body applications.  This presentation will explore the contribution of DWI in the routine evaluation of spinal conditions focusing on its role in the detection, characterization and surveillance of neoplastic, degenerative and infectious diseases.  MR spectroscopy has the power to delineate the chemical signature of tissues in health and disease.  Research suggests detection of key MRS biomarkers may have a role analogous to provocative discography in identification of the painful disc.  This presentation will cover the key findings in the painful disc and review the research work done to date.

Cynthia Chin1, Jason Talbott1, Ethan Neufeld2, Gabriel Runner2, and Peter Shen2
1UC San Francisco, CA, United States, 2UC Davis, CA, United States
Review of the anatomy of the brachial plexus and lumbosacral plexus and the pathologies resulting in plexopathy and their imaging characteristics.

New Imaging Techniques for Spine & Plexus
Julien Cohen-Adad1,2
1Department of Electrical Engineering, Ecole Polytechnique de Montreal, Montreal, QC, Canada, 2Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada
While multi-parametric MRI (mpMRI, which includes functional MRI, diffusion tensor imaging, etc.) has become popular for brain imaging, it is still difficult to apply these techniques to the spine because of complex issues related to acquisition and processing of the data. In this review we will examine several key aspects of mpMRI in the spine, namely: hardware, pulse sequences and image processing techniques – discussing their present status, unresolved issues, and future directions. 

Break & Meet the Teachers
      Moderator: Suchandrima Banerjee  
Malformations of Cortical Development - Permission Withheld
Robert C McKinstry1
1Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, United States
This lecture presents an update on the genetics, signaling pathways and abnormal microstructure that lead to malformations of cortical development.  The organization of this talk is one framework for moving beyond description of the phenotype to a mechanistic understanding of cortical malformations.

Pediatric: Tumours
Toshio Moritani1
1Department of Radiology, University of Iowa Hospitals & Clinics, Iowa City, IA, United States
Pediatric brain tumors are a leading cause of cancer-related death in children. In recent years, new technologies of molecular and genetic analysis of pediatric brain tumors have provided abundance of biological information. This has resulted in refining tumor classification into subgroups with potential clinical implications and treatment. This lecture demonstrates imaging findings and pathology of pediatric brain tumors and associated genetic syndromes, and an overview of recent developments in molecular biology and genetics. This knowledge is important for the diagnosis, management and future treatment of pediatric brain tumors as well as guiding future research. 

Perinatal Brain Injury & Mimics
P. Ellen Grant1
1Boston Children's Hospital
Lunch & Meet the Teachers
      CNS Infections  
      Moderator: Toshiaki Taoka  
CNS Infections: Tropical
CC Tchoyoson Lim1,2
1Neuroradiology, National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS School of Medicine, Singapore, Singapore
In today’s highly connected world, radiologists should be familiar with typical MRI findings of CNS manifestations of common tropical diseases, as well as the limitations of neuroimaging in differential diagnosis. Multi-disciplinary consultations between radiologists, neurologist, infectious disease specialists and neurosurgeons are often helpful to refine the clinical diagnosis and plan a rational approach to management. Newer techniques, including MR spectroscopic and perfusion imaging, may also be helpful for differential diagnosis.  This presentation will focus on differential diagnosis in schistosomiasis and neurocysticercosis, and outbreaks of Nipah virus, group B streptococcus agalactiae infection.

CNS Infections: Bacterial/Fungal
Seung Hong Choi1
1Radiology, Seoul National University
CNS Infections: Viral
Cheng-Yu Chen
Viruses that tend to affect the central nervous system are usually neurotropic. The specific diagnosis of viral encephalitis requires PCR, serum biomarkers, or culture which are not available at acute setting, while clinical and laboratory findings are often non-specific. MR Imaging study is important in confirming the CNS involvement. Imaging lesion detection can prompt early antiviral treatment until proven otherwise. Imaging approaches to viral CNS infection require background knowledge of the patients, such as ages, host immunity, clinical presentations, geographic considerations and endemics. This lecture will review the basic concepts of MR imaging approaches to common neurotropic viral encephalitis. 

Break & Meet the Teachers
      Psychiatric Disease  
      Moderator: Kelvin Lim  
Biological Origin of Depression: Evidence from Infant Brain Imaging and Genetics
Qiu Anqi
Psychiatric Disease: Post-Traumatic Stress Disorder
Qiyong Gong1
1Huaxi MR Research Center (HMRRC), Dept of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of
This lecture will provide a brief review on the Post-Traumatic Stress Disorder (PTSD) in general,and an overview of the PTSD related brain abnormalities discovered with the use of psychiatric MR, with particular emphasis on the circuitry impairment as observed from the circuit- and network-based analysis. Methodological challenges and opportunities will be discussed, along with the assessment of the clinical usefulness of the research findings using psychiatric MR imaging into the objective diagnosis, prognostic prediction and treatment evaluation of patients with PTSD.

Adjournment & Meet the Teachers

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.