ISMRM 25th Annual Meeting & Exhibition 22-27 April 2017 Honolulu, HI, USA

Sunrise Educational Session: The Consequence of Inter-Compartmental Water Exchange in the DCE-MRI Time-Course
Sunrise Session

ORGANIZERS: Linda Knutsson, Ph.D. & Steven P. Sourbron, Ph.D.

Thursday, 27 April 2017
Room 316A  07:00 - 07:50 Moderators: Joseph Ackerman, Kathleen Schmainda

Skill Level: Intermediate

Slack Channel: #e_diff_perf_fmri
Session Number: STh05

This is a discussion session on the controversial topic of inter-compartmental water exchange in DCE-MRI, specifically the claim that encoded in the data is information on equilibrium water exchange kinetics in addition to contrast agent pharmacokinetics. Two experienced speakers will be asked to present their views on the topic in a 15-min pitch. This will be followed by a 20-min debate including the speakers, a moderator and the audience.

Target Audience
The session is targeted at basic scientists, biomedical engineers and clinicians interested in DCE-MRI of brain and body with a focus on perfusion, permeability, and metabolic aspects.

Educational Objectives
Upon completion of this course, participants should be able to:
-Distinguish the basic difference between the water-exchange and the tracer-exchange paradigm;
-Explain the conceptual arguments underpinning opposing views; and
-Demonstrate a good overview of the experimental evidence supporting either side of the argument.

DCE-MRI is Enriched by Water Exchange - permission withheld
Charles Springer, Jr.
This is the syllabus for a Sunrise Educational Session presentation. 

Data Acquired Using DCE-MRI are Unsuitable for Measuring Water Exchange
David Buckley
DCE-MRI experiments are designed to measure tracer exchange. We can choose to make them sensitive to water exchange but in doing so we compromise their ability to measure tracer exchange, particularly their ability to measure the arterial input function (AIF). The choice is simple, EITHER measure tracer exchange parameters alone and well OR measure tracer exchange and water exchange parameters together but poorly.


The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.