ISMRM 25th Annual Meeting & Exhibition • 22-27 April 2017 • Honolulu, HI, USA

Sunrise Educational Session: Bleeding Edge of Brain Techniques: Beyond Conventional MRI
Sunrise Session

ORGANIZERS: Fernando E. Boada, Ph.D. & Christopher P. Hess, M.D., Ph.D.

Tuesday, 25 April 2017
Room 311  07:00 - 07:50 Moderators: Fernando Boada, Christopher Hess

Skill Level: Intermediate

Slack Channel: #e_neuro
Session Number: STu06

This course provides a comprehensive tutorial on emerging MRI methodologies for studying and characterizing the human brain. The basic methodological requirements in order to obtain meaningful information from the CNS using such techniques will be introduced as well as the advantages and limitations of each technique in the setting of impotent physiological and pathological states.

Target Audience
Target audience is MR scientists and clinicians interested in gathering the operational knowledge required to use these techniques for studying basic and pathological brain metabolism as well as diagnosing clinically relevant conditions.

Educational Objectives
Upon completion of this course, participants should be able to:

-Appraise the role of emerging techniques for the non-invasive MRI of brain function;
-Outline data acquisition requirements for effective application of these techniques; and
-Summarize physiological parameters that can be measured in a clinical and/or research setting.

Sodium MRI in the Clinic: What You Can Learn from a 10 Min Scan
Armin Nagel
Sodium Ions (Na+) play an important role in many cellular physiological processes. In healthy tissue, the extracellular concentration of Na+ is approximately ten-fold higher than the intra­cellular concentration. A breakdown of this concentration gradient or an increase of the intracellular sodium content can be used as an early marker in many disease processes. In this presentation the focus will be on brain-related applications of sodium MRI. In addition, the required hardware, as well as image acquisition and post-processing techniques that are suitable for sodium MRI will be discussed.

Conventional MRI: What We are Missing - video not available
Keith Thulborn
Metabolic MR imaging at ultrahigh field using MR signals such as sodium (23Na) and oxygen (17O) advances medical imaging beyond the current paradigm of anatomical description to metabolic bioscales. Diseases with long prodromes, including neurodegenerative diseases such as Alzheimer's disease and musculoskeletal diseases such as osteoarthritis, will be reviewed for human applications. Sensitive detection of early pathology prior to anatomic changes allows these quantitative parameters to serve as objective outcome measures for evaluating clinical trials of early interventions. Eliminating the need for subjective outcome measures of clinical disease severity would revolutionize drug discovery for early intervention. 


The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.