ISMRM 25th Annual Meeting & Exhibition • 22-27 April 2017 • Honolulu, HI, USA

Sunrise Educational Session: Assessing Response to Immunotherapy
Sunrise Session

ORGANIZERS: Linda Moy, M.D. & Valeria Panebianco, M.D.

Tuesday, 25 April 2017
Room 314  07:00 - 07:50 Moderators: Carolyn Mountford, Linda Moy

Skill Level: Intermediate to Advanced

Slack Channel: #e_cancer_mol_mrs
Session Number: STu07

Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors. This novel treatment uses certain components of a person’s immune system to fight malignancy either as a single chemotherapy agent or in combination with existing chemotherapy regimens. Immunotherapy includes monoclonal antibodies targeted to a specific receptor in cancer cells or cancer vaccines. There is an unmet need to develop targeted imaging agents to assess response to immunotherapy.

Target Audience
There is a broad range of attendees that may benefit from this course. Cancer imaging specialists that are interested in immunotherapy. MR physicist who desire to learn more about this novel treatment. Attendees who are interested in targeted imaging agents.

Educational Objectives
Upon completion of this course, participants should be able to:
-Review how the immune system may fail to recognize cancer cells as foreign;
-Explain how immunotherapy helps the immune system recognize cancer cells and strengthen its response to destroy these cancer cells; and
-Recognize the limitations of current MRI techniques to assess response to immunotherapy.

Brain Gliomas: Imaging Response to Immunotherapy
Alberto Bizzi
Investigation & Evaluation of Immunotherapies with Molecular Imaging
Kimberly Brewer, Marie-Laurence Tremblay, Zoe O'Brien-Moran, James Rioux
Immunotherapies are becoming increasingly important for improved treatment of a variety of cancer types. However, the development of these novel therapies has outstripped our understanding of underlying mechanisms and how best to apply them. It is therefore crucial that we use tools such as MRI, and other molecular imaging techniques, to evaluate immunotherapies in both the clinic and in preclinical studies, and develop new probes and biomarkers to increase their efficacy. This talk will explore the work being done by a number of labs utilizing MRI, including the development of novel probes and biomarkers (both prognostic and diagnostic).


The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.