ISMRM 25th Annual Meeting & Exhibition • 22-27 April 2017 • Honolulu, HI, USA

Educational Session: Susceptibility Imaging as a New Window on Disease, Iron & Hypoxia

Educational Course

ORGANIZERS: Jeff F. Dunn, Ph.D. & Linda Moy, M.D.

Tuesday, 25 April 2017
Room 316A  13:45 - 15:45 Moderators: Hongfu Sun, Alan Wilman

Skill Level: Basic to Intermediate

Slack Channel: #e_cancer_mol_mrs
Session Number: Tu03

Susceptibility relates to inhomogeneous magnetic fields as will be caused by iron deposition, hypoxia, tracer response, altered blood vessel structures, and changes in tissue structure. In most clinical conditions or diseases, there are changes in the naturally occurring susceptibility. In addition dedicated contrast agents that exploit this contrast mechanism can be developed. How can the clinician and scientist capitalize on this sensitive contrast mechanism to improve diagnosis and monitoring of disease?

Target Audience
Scientists and clinicians who want to learn how and why one would incorporate susceptibility imaging into their research or clinical work to investigate disease or diseases models.

Educational Objectives
Upon completion of this course, participants should be able to:
-Define the terms BOLD, GRE and susceptibility;
-Describe how susceptibility imaging could improve imaging of cancer;
-Explain how susceptibility imaging could improve imaging of conditions involving hypoxia/ischemia;
-Explain how susceptibility imaging could improve imaging of conditions involving brain related disorders; and
-Describe some key aspects of how susceptibility imaging is improving molecular imaging and cell tracking as emerging technologies.

Using Desoxyhemoglobin & Susceptibility as a Contrast Agent in Cancer
Gregory Karczmar
Abdominal Cancer
Bachir Taouli
In this lecture, we will review the current susceptibility imaging methods used for indirectly assessing tumor hypoxia in abdominal cancers, in preclinical and clinical applications. We will review the scientific evidence, potential applications and limitations of BOLD/TOLD imaging.

Cell Tracking & Molecular Contrast
Paula Foster
This lecture will discuss the use of iron based contrast agents for cellular and molecular MRI. The mechanisms of contrast, detection limits, limitations and advances will be described. 

Susceptibility Mapping in Brain Diseases: Iron, Myelin & More
Karin Shmueli
Tissue magnetic susceptibility can be calculated from gradient-echo phase images using quantitative susceptibility mapping (QSM). Several clinical applications of QSM are emerging based on its sensitivity to tissue iron, myelin and deoxyhaemoglobin content. These include visualising iron in deep-brain structures in Parkinson’s disease and other dementias, evaluating microbleed burden and haemorrhages and distinguishing these from calcifications. QSM also allows quantification of venous oxygenation with functional QSM now able to detect brain activity. QSM reveals demyelination: changes in both myelin and iron content drive QSM differences in Multiple Sclerosis which may be associated with inflammation, perhaps due to iron in microglia/macrophages.


The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.