ORGANIZERS: Anke Henning, Ph.D., Gregory J. Metzger, Ph.D. & Valeria Panebianco, M.D.
Wednesday, 26 April 2017
||13:45 - 15:45
||Moderators: Gregory Metzger, Valeria Panebianco
Skill Level: Intermediate
Slack Channel: #e_cancer_mol_mrs
Session Number: W03
Proton (1H), phosphorus (31P) and carbon (13C) spectroscopy is being used outside the brain to explore tissue properties, metabolism , energetics, and metabolic state in vivo. We will emphasize the unique acquisition, processing and interpretation challenges/opportunities in the non-neuro applications by focusing on specific applications in the human body. In this session state-of-the art body MRS methodology including the most recent technical improvements as well as current and potential future clinical applications will be discussed.
Basic researchers and clinicians interested in exploring the methods and applications of MRS outside the brain.
Upon completion of this course, participants should be able to:
-Identify applications for proton (1H) body spectroscopy in basic research and clinical applications;
-Recognize the potential of performing multi-nuclear spectroscopy in the body;
-Recall the specific strategies used in the body to overcome the challenges compared to the brain; and
-Identify the additional benefits and difficulties associated with increasing field strength.
|Prostate Cancer: Proton & Beyond
The use of proton spectroscopic imaging in prostate cancer at clinical field strengths of 1.5 and 3T will be discussed. Moreover, latest developments at 3T, as well as the possibilities of 7T are shown for proton as well as phosphorous spectroscopic imaging, culminating in the ultimate multi-parametric MRI examination...
Magnetic resonance imaging (MRI) has high sensitivity for detection of breast cancer but low specificity. Qualitative and quantitative measurements of choline containing (tCho) compounds by MR spectroscopy have shown promise in diagnosis as well as in non-invasive therapeutic assessment of breast cancer. Diffusion weighted imaging (DWI) allows mapping of apparent diffusion coefficient (ADC) of tissues. The lower ADC value has been reported in malignant compared to benign disease. Use of these techniques in combination has been documented to increase the specificity of MRI. This talk highlights the role of MRS and DWI in breast cancer management.
|MRS in Hepatic Disease
The 1H MR spectrum of the liver is dominated by a water peak and peaks associated with fat. This talk will examine the technical challenges associated with MRS of fat and water in the liver and examine how to minimize or correct confounders associated with estimation of three tissue properties: Proton Density Fat Fraction, Liver Triglyceride Composition, and Liver Water and Fat Relaxation.
Magnetic resonance spectroscopy (MRS)1-4 is a method for non-invasively probing metabolism. The major nuclei studied by MRS methods in the heart include 1H (for measures of fat fraction, creatine content, etc), 31P (for measures of energy transport through the creatine-kinase system in the form of ATP, phosphocreatine, and their kinetics, and for determination of pH), 13C (for stable-isotope tracer studies, and more recently with hyperpolarised pyruvate to study glycolysis), and more recently 17O (to trace oxidative respiration) and other nuclei. This lecture provides an overview of the major methods of cardiac spectroscopy and their contributions to biomedicine.