ISMRM 25th Annual Meeting & Exhibition • 22-27 April 2017 • Honolulu, HI, USA

Weekend Educational Course: Imaging Biomarkers of Brain Disorders
Weekend Course

ORGANIZERS: Kelvin O. Lim, M.D. & Kei Yamada, M.D.

Saturday, 22 April 2017
Room 316BC  13:15 - 17:15 Moderators:  Kelvin Lim, Kei Yamada

Skill Level: Intermediate

Slack Channel: #e_neuro
Session Number: WE12

This course will study the use of imaging biomarkers in three brain disorders. Following a overview presentation introducing available imaging biomarkers and concepts related to their clinical translation, there will be presentations on the clinical and technical perspectives in three specific clinical areas: Parkinson's disease, depression and epilepsy. This will be followed by an interactive session with the audience.

Target Audience
This course is meant to appeal to students, scientists, physicists, engineers, and clinicians interested in learning more and contributing to this rapidly developing area of imaging biomarkers.

Educational Objectives
Upon completion of this course, participants should be able to:
-Appraise the value of current imaging techniques as a biomarker;
-Summarize the current use of biomarkers in depression, epilepsy, and Parkinson's disease; and
-Apply emerging biomarkers to other brain disorders.


Diffusion as a Biomarker for Brain Disease
Koji Sakai
This session focuses on and tries to appraise diffusion MRI (dMRI)-derived imaging biomarkers (dMRI-IB) for brain disease. To categorize dMRI-IB: 1) confirm the definition of IB; 2) proceed through dMRI-derived measures and applications; 3) introduce the possible candidate of dMRI-IB; and 4) discuss about barriers that dMRI-IB candidates should overcome. In addition, this session will address following issues: 1) why only limited dMRI measures can be considered for IB? 2) what is the problem for dMRI-IB candidates to become true IB? 3) what can we do for creating new IB?

fMRI as a Biomarker for Brain Disease
Vince Calhoun
In this talk I will discuss current progress and challenges in the use of brain imaging for single subject prediction.

MRS as a Biomarker for Brain Disease - permission withheld
Carolyn Mountford
Panel Discussion
Break & Meet the Teachers
State of the Art - Depression
Kathryn Cullen
Major depressive disorder is a serious public health problem, representing a leading cause of worldwide disability, and a major contributor to suicide. While treatments exist to address this problem, they are not always efficacious, highlighting the need for more research to better understand the neural circuitry underlying depression and its treatment. In the past 2 decades, human neuroimaging research has made great strides in providing information about which neural circuits are implicated in depression. In this talk we will review some of the major contributions to this body of knowledge including research using structural neuroimaging, positron emission tomography, and functional magnetic resonance imaging. We will also discuss the smaller but emerging literature using these tools in the context of clinical trials to begin to understand predictors and mechanisms of treatment response in patients with depression. While there have been great strides forward in understanding the neural circuitry underlying depression, much work still remains before this knowledge can be applied in the clinic.  Heterogeneity in the findings across studies may reflect heterogeneity of MDD itself, where individuals that fall under the same diagnosis may have different neural circuitry signatures. Advanced methods that are designed to better understand these differences across subjects could provide the traction needed to develop personalized treatment approaches.

State of the Art - Epilepsy
Andre Obenaus
Epilepsy is a broad syndrome that results in societal, economic and medical burdens. Identification and development of MRI based biomarkers  that are predictive of epileptogenesis are urgently needed. We describe the development of one such biomarker for febrile seizures. Once definitive biomarker imaging approaches have been validated, therapeutic interventions can then be investigated.

State of the Art - Parkinson's Disease
Toshiaki Taoka
The major role of the imaging used to be ruling out other disorders which present the symptoms of Parkinsonism. However, there are several imaging method which can visualize the abnormality in the Parkinson’s disease including neuromelanin image, diffusion images or susceptibility weighted imaging. This lecture will discuss on the recently developed imaging method for Parkinson’s disease or related disorders.

Panel Discussion



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