ORGANIZERS: Alex L. MacKay, D.Phil. & Andre Obenaus, Ph.D.
Sunday, 23 April 2017
||08:15 - 12:15
||Tim Duong, Andre Obenaus
Skill Level: Basic to Advanced
Slack Channel: #e_neuro
Session Number: WE23
The role of neuroimaging in traumatic brain injury (TBI) is critical for diagnosis, testing and montioring therapies and evaluation of long-term outcomes. The session will discuss established and emerging imaging approaches relevant to improving translational research and care of patients impacted by TBI.B42.
This course is intended to provide a clinical and translational science overview of MRI approaches and advances in TBI for students, clinicians, physicists and scientists to ultimately improve care for TBI patients.
Upon completion of this course, participants should be able to:
-Compare currently available MR methods for detecting and characterizing TBI;
-Explain current and future advances on the horizon for neuroimaigng of TBI; and
-Recognize how ongoing large scale clinical studies may impact diagnosis and care for TBI patients.
|MRI in Current Clinical Practice for TBI
|Animal Models for MRI in TBI
TBI is devastating yet currently without a cure. Investigators are seeking therapeutic strategies through the preclinical animal model to elucidate changes occurring after brain injury and identify potential neuroprotective therapies for brain-injured patients. The choice of animal model depends on the research goal and underlying objectives. This lecture will introduce the animal models of TBI commonly used for MRI study and explain their biomechanical, pathological and neurological differences in characteristics. Recent advances of MRI in probing the pathophysiology responses in experimental TBI will also be reviewed.
|Advances in White Matter Imaging - permission withheld
|Neurovascular Consequences of Traumatic Brain Injury
Blood flow dysregulation is known to occur immediately after traumatic brain injury. Since neurovascular coupling is an essential component for maintaining the health of the neurovascular unit, impairment of this important regulatory mechanism can have significant implications on recovery from injury and may therefore be involved in the persistence of symptoms after injury. The ability to map dysregulation of blood flow using BOLD MRI cerebrovascular reactivity mapping offers the ability to investigate blood flow control providing a method to further understanding the relationship between post-injury blood flow derangements and recovery from injury.
|Break & Meet the Teachers
|Brain inflammation in Trauma – MRI, MRS & New Radioligands
Both early and chronic inflammation are therapeutic targets in brain trauma. New PET radioligands allow targeting of several key components of the CNS inflammation. This talk will review the emerging PET tracers for neuroinflammation, and consider them in the context of experimental traumatic brain injury, temporal disease progression, and available MRI and MRS approaches.
|Large Scale Clinical Studies in TBI
|Controversies in TBI
Erin Bigler, Erin Bigler
Enduring neuroimaging controversies exist in the study of traumatic brain injury (TBI) especially related to mild TBI (mTBI). The presentation begins with a brief historical overview of various definitional statements as to what constitutes a TBI, especially involving “concussion.” Although various lesion quantification methods have become standard, when to scan post-injury and what to quantify remain part of the debate. Individual differences and the heterogeneity of the injury complicate and may mask effects at the individual level. With advanced neuroimaging techniques, controversies remain as to acquisition, post-processing and study design questions and what outcome metrics should be examined.