Joint Annual Meeting ISMRM-ESMRMB • 16-21 June 2018 • Paris, France

Weekend Educational Course
Novel Approaches in Molecular Imaging
Novel Approaches in Molecular Imaging: Part 1
Weekend Course

ORGANIZERS: Natalie Serkova, Damian Tyler

Saturday, 16 June 2018
S04  13:15 - 14:45 Moderators:  Natalie Serkova, Damian Tyler

Skill Level: Basic to Intermediate
Session Number: WE-10A

Overview
This session will provide a introductory overview on the physics and application of novel approaches in molecular imaging. Topics to be covered will include PET-MR, Hyperpolarization, CEST agents and the use of nanoparticles.

Target Audience
All physics and biology graduate students and clinical and post-doctoral trainees plus experienced PhD and MDs who would like to expand their knowledge and practice in molecular imaging.

Educational Objectives
As a result of attending this course, participants should be able to:
-Describe the basics of novel and advanced molecular imaging technologies;
-Discuss the technological basis of these advanced techniques; and
-Compare and contrast the pre-clinical, translational and clinical applications of advanced molecular imaging techniques.


13:15
   PET-MRI: The Application
Did Not Present
Andreas Kjaer
13:55
 Hyperpolarized 13C MRI: The Technical Aspects from Hamiltonian to Homo sapien
Jack Miller
We will examine the mechanistic details behind dissolution-Dynamic Nuclear Polarisation with small molecules for in vivo applications, and additionally discuss some of the technical challenges that arise in the design of pulse sequences to use the magnetisation that the technique generates. 
14:35
   Hyperpolarized 13C MRI: The Application
Jessica Bastiaansen
15:15 
   Break & Meet the Teachers
 
Novel Approaches in Molecular Imaging: Part 2
Weekend Course

ORGANIZERS: Natalie Serkova, Damian Tyler

Saturday, 16 June 2018
S04  15:15 - 16:45 Moderators:  Natalie Serkova, Damian Tyler

Skill Level: Basic to Intermediate
Session Number: WE-10B

Overview
This session will provide a introductory overview on the physics and application of novel approaches in molecular imaging. Topics to be covered will include PET-MR, Hyperpolarization, CEST agents, and the use of nanoparticles.


Target Audience
All physics and biology graduate students and clinical and post-doctoral trainees, plus experienced Ph.D.'s and M.D.'s who would like to expand their knowledge and practice in molecular imaging.


Educational Objectives
As a result of attending this course, participants should be able to:
-Describe the basics of novel and advanced molecular imaging technologies;
-Discuss the technological basis of these advanced techniques; and 
-Compare and contrast the pre-clinical, translational, and clinical applications of advanced molecular imaging techniques.


15:15
   CEST MRI: The Technical Aspects
Michael McMahon
Chemical Exchange Saturation Transfer (CEST) imaging has emerged as an attractive alternative MRI contrast mechanism to T1 and T2 contrast (1-7). This lecture will cover the basic steps in generating CEST contrast maps, including acquisition, B0 map creation, and Post-processing of CEST MRI data.
15:37
   CEST MRI: The Application
Kevin Ray
During this presentation, I will discuss some of the difficulties of clinical translation of CEST MRI, highlight the similarities and differences between endogenous and exogenous CEST MRI methods, and outline some of the principle applications of these methods in pre-clinical and clinical settings. Examples of such applications include: (1) pH imaging in ischaemic stroke using endogenous amide proton transfer, (2) pH imaging in cancer using exogenous diaCEST and paraCEST agents, (3) endogenous metabolite concentration imaging (e.g. GluCEST, GagCEST, GlycoCEST), and (4) glucose uptake and perfusion imaging using GlucoCEST.
15:59
   Nanoparticle-Based Imaging: The Technical Aspects
Kevin Bennett
This presentation will outline the physical chemical and physical basis for nanoparticle contrast agent development, modification, and detection for imaging by MRI. Several emerging nanoparticle agents will be discussed in detail.
16:21
   Nanoparticle-Based Imaging: The Application
Heike Daldrup-Link
This presentation will provide an overview of clinical applications of iron oxide nanoparticles for MR imaging and PET/MR imaging of patients with cancer. This will include safety considerations, applications for whole body cancer staging, applications for monitoring response to cancer immunotherapies and theranostic (combined therapeutic and diagnostic) applications.
16:45
   Adjournment & Meet the Teachers
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